ACR Meeting Abstracts

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Abstracts tagged "autoantibodies and plasma cells"

  • Abstract Number: 2792 • 2018 ACR/ARHP Annual Meeting

    The Effect of B Cell Targeted Therapies on Autoantibodies and Excessive Neutrophil Extracellular Trap Formation in Systemic Lupus Erythematosus

    Laura van Dam1, Zgjim Osmani1, Tineke Kraaij1, Sylvia W.A. Kamerling1, Jaap A. Bakker2, Hans U. Scherer3, Ton Rabelink1, Reinhard Voll4, David A. Isenberg5, Cees van Kooten1 and Y.K. Onno Teng1, 1Nephrology, Leiden University Medical Center, Leiden, Netherlands, 2Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 5University College London, London, United Kingdom

    Background/Purpose: Systemic lupus erythematosus (SLE) is a severe systemic autoimmune disease characterized by immune-complexes (ICx) which cause inflammation and damage. Effective targeting of autoantibody secreting…
  • Abstract Number: 25 • 2013 ACR/ARHP Annual Meeting

    SLE Flares Are Characterized By Generalized Polyclonal Expansions Of Antibody Secreting Cells Without Preference For Autoimmune Responses

    H. Travis Ichikawa, Medicine, Emory University, Atlanta, GA

    Background/Purpose: Increased circulating antibody secreting cells (ASC), including both CD138- plasmablasts and CD138+ plasma cells (PB/PC), correlate with SLE activity and are prominent during Lupus…
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