Abstracts tagged "autoantibodies and autonomic disorders"

Abstract Number: 504 • 2012 ACR/ARHP Annual Meeting
Pathogenic Autoantibodies to the Anti-Muscarinic Type 3 Receptor Act by Competitive Inhibition of Acetylcholine-Mediated Receptor Signalling in Sjögren’s Syndrome
Michael W. Jackson¹, Isabell Bastian² and Thomas P. Gordon³, ¹Immunology, Flinders University, Adelaide, Australia, ²Immunology, Allergy and Arthritis, Flinders University and Flinders Medical Centre, Adelaide, Australia, ³Immunology Allergy & Arthritis, Flinders Medical Centre, Bedford Park, Australia
Background/Purpose: Primary Sjögren’s syndrome (SS) is a systemic autoimmune disorder characterized by exocrine failure and widespread autonomic dysfunction. Functional autoantibodies (Abs) directed against the muscarinic…

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Abstracts tagged "autoantibodies and autonomic disorders"

Pathogenic Autoantibodies to the Anti-Muscarinic Type 3 Receptor Act by Competitive Inhibition of Acetylcholine-Mediated Receptor Signalling in Sjögren’s Syndrome