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Abstracts tagged "autoantibodies and autoantigens"

  • Abstract Number: 2932 • 2016 ACR/ARHP Annual Meeting

    HLA-DR3 Restricted Response to Lupus-Related Auto-Antigen Smd: Autoreactive T Cells Are Inherent in Normal Immune Repertoires

    Zhenhuan Zhao1, Jiling Ren1, Chao Dai2, Carol Kannapell1, Qian Wang3, Felicia Gaskin4 and Shu Man Fu5, 1Medicine/CIIR/Rheumatology, University of Virginia, Charlottesville, VA, 2Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, 3University of Virginia, Charlottesville, VA, 4Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, 5Department of Medicine, University of Virginia, Charlottesville, VA

    Background/Purpose: HLA class II is the major susceptibility region for systemic lupus erythematosus (SLE) and other autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and…
  • Abstract Number: 608 • 2014 ACR/ARHP Annual Meeting

    Identification of Novel Autoantibodies in Patients with Ankylosing Spondylitis Using Human Protein Microarray

    Matthew Presby1, Mark J. Soloski1, John A. Flynn2, Clifton O. Bingham III1, Michael M. Ward3 and Grant H. Louie4, 1Johns Hopkins University, Baltimore, MD, 2Dept of Medicine, Johns Hopkins University, Baltimore, MD, 3Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, 4Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose:   Ankylosing spondylitis (AS) is an immune-mediated disease for which the search for autoantibodies has been elusive. Conventional immunoserological approaches are slow and limited…
  • Abstract Number: 2522 • 2013 ACR/ARHP Annual Meeting

    Novel Autoantibody Against CAF-1 Is a Biomarker For CNS Manifestation in patients With SLE

    Kentaro Doe1, Kazuhisa Nozawa2, Kaori Hiruma2, Yusuke Yamada1, Yuko Matsuki1, Soichiro Nakano1, Michihiro Ogasawara3 and Yoshinari Takasaki4, 1Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of internal medicine and rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 4Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Proliferating cell nuclear antigen (PCNA) is known to be an autoantigen specifically recognized by antibodies in sera from patients with systemic lupus erythematosus (SLE).  Although a prevalence of anti-PCNA…
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