Abstracts tagged "auto-immunity and transcription factor"

Abstract Number: 1909 • 2016 ACR/ARHP Annual Meeting
The Transcription Factor Fra2 Is Playing a Key Role in Treg Development and Autoimmunity
Florian Renoux¹, Mara Stellato², Daniela Impellizzieri³, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jeorg HW Distler⁶, Gabriela Kania², Onur Boyman³ and Oliver Distler², ¹Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Decreased numbers or altered functions of regulatory T cells (Tregs) have been reported in many inflammatory rheumatic diseases, and Tregs are considered promising…