Abstracts tagged "auto-immunity and signal transduction"

Abstract Number: 2871 • 2014 ACR/ARHP Annual Meeting
Break of Anergy in Human Autoreactive B Cells By T Helper Signals Restores B Cell Receptor Signaling Capacity and Is Dependent on Upregulation of CD45 Phosphatase Activity-a Possible Novel Mechanism of Breech of B Cell Tolerance in Rheumatic Diseases
Peter Szodoray¹, Stephanie M. Stanford², Nunzio Bottini² and Britt Nakken¹, ¹Institute of immunology, Rikshospitalet, Oslo University Hospital, Oslo, Norway, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA
Background/Purpose : We recently identified a human B cell population, which is naturally autoreactive and tolerized by functional anergy. This population was naïve, fully mature,…

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Abstracts tagged "auto-immunity and signal transduction"

Break of Anergy in Human Autoreactive B Cells By T Helper Signals Restores B Cell Receptor Signaling Capacity and Is Dependent on Upregulation of CD45 Phosphatase Activity-a Possible Novel Mechanism of Breech of B Cell Tolerance in Rheumatic Diseases