Abstracts tagged "auto-immunity and rheumatoid arthritis (RA)"

Abstract Number: 2797 • 2018 ACR/ARHP Annual Meeting
Regulation of Autoimmune T Cells By the Co-Receptors CD28 and PD-1
Sabina Sandigursky¹ and Adam Mor², ¹Medicine, NYU School of Medicine, New York, NY, ²Rheumatology and Pathology, NYU School of Medicine, New York, NY
Background/Purpose: T cells play a major role in the pathogenesis of Rheumatoid Arthritis (RA). These cells are regulated by signals provided via the T cell…
Abstract Number: 862 • 2017 ACR/ARHP Annual Meeting
iNKT Mediated Immunoregulatory Feedback Control Development of Autoimmune Arthritis in Mice
Mattias N. D. Svensson^1,2, Meng Zhao³, Mitchell Kronenberg³ and Nunzio Bottini^1,2, ¹Department of Medicine, University of California San Diego, La Jolla, CA, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA
Background/Purpose: Invariant Natural Killer T cells (iNKT) express an invariant T cell receptor (TCR) alpha chain and recognize lipid antigens – such as alpha-GalCer (aGC),…
Abstract Number: 1100 • 2015 ACR/ARHP Annual Meeting
Citrullinated Antigen-Specific B Cells in Peripheral Blood and Synovial Fluid of Patients with Rheumatoid Arthritis: Identification and Phenotypic Characterization
Priscilla Kerkman¹, Ellen I.H. van der Voort¹, Arnaud Zaldumbide², Emeline Fabre¹, Yoann Rombouts¹, Theo Rispens³, Gertjan Wolbink⁴, Rob Hoeben², Hergen Spits⁵, Dominique Baeten⁶, T. W. J. Huizinga¹, René E. M. Toes¹ and Hans Ulrich Scherer¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands, ³Sanquin Research, Amsterdam, Netherlands, ⁴Immunopathology, Sanquin Research, Amsterdam, Netherlands, ⁵Department of Cell Biology and Histology, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ⁶Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of anti-citrullinated protein antibodies (ACPA) in the majority of patients. ACPA represent highly disease-specific biomarkers that…

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