Abstracts tagged "auto-immunity and interferons"

Abstract Number: 3025 • ACR/ARHP Annual Meeting 2015
FcγRIIIa-Psyk Signaling up-Regulates TLR3 and TLR5 in Human Naïve CD4+ T-Cells
Chen Chen¹, Ye Bi², Terry Moore³ and Anil K. Chauhan⁴, ¹Rheumatology/Internal Medicine, Saint Louis University, St. Louis, MO, ²Internal Medicine, Saint Louis University, St. Louis, MO, ³Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO, ⁴Internal Medicine-Rheumatology, Saint Louis University, St Louis, MO
Background/Purpose: To delineate mechanism of FcγRIIIa-pSyk signal in TH17 and IFN-γhigh subset development. To examine whether Toll-like receptor signaling play a role in CD4+ T-cell…
Abstract Number: 2172 • ACR/ARHP Annual Meeting 2014
PTPN22 Promotes TLR-Induced Amelioration of Arthritis
David Ewart¹, Erik J. Peterson¹ and Yaya Wang², ¹University of Minnesota, Minneapolis, MN, ²Center for Immunology, University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) synovial fluid exhibits high levels of type 1 interferons (IFN). Type 1 IFN may exert potent anti-inflammatory effects, since a TLR3…