ACR Meeting Abstracts

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Abstracts tagged "Atherosclerosis"

  • Abstract Number: 0271 • ACR Convergence 2021

    Higher Prevalence of Subclinical Atherosclerosis in the First Five Years of Rheumatoid Arthritis Diagnosis

    Natalia Guajardo-Jauregui, Dionicio Galarza-Delgado, Iris Colunga-Pedraza, Jose Azpiri-Lopez, Alejandra Rodriguez-Romero, Julieta Loya-Acosta, Alejandro Meza-Garza, Jesus Cardenas-de La Garza, Salvador Lugo-Perez and Jessica Castillo-Treviño, Hospital Universitario "Dr Jose E. Gonzalez", Monterrey, Mexico

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a higher risk of developing a cardiovascular (CV) event than the general population, due to an accelerated process…
  • Abstract Number: 0276 • ACR Convergence 2021

    Pulse Pressure as a Predictor of Carotid Plaque in Rheumatoid Arthritis Patients

    Natalia Guajardo-Jauregui, Iris Colunga-Pedraza, Jose Azpiri-Lopez, Dionicio Galarza-Delgado, Alejandra Rodriguez-Romero, Julieta Loya-Acosta, Alejandro Meza-Garza, Jesus Cardenas-de La Garza, Salvador Lugo-Perez and Jessica Castillo-Treviño, Hospital Universitario "Dr Jose E. Gonzalez", Monterrey, Mexico

    Background/Purpose: Pulse pressure (PP) is defined as the difference between systolic and diastolic blood pressure and represents arterial compliance and reflective properties of blood flow.…
  • Abstract Number: 0282 • ACR Convergence 2021

    5-Year Cardiovascular Event Risk in Early Rheumatoid Arthritis Patients Who Received Treat-to-Target Management: A Population-based Cohort Study

    Tsz On Lam1 and Lai-Shan Tam2, 1Prince of Wales Hospital, Hong Kong, Hong Kong, 2Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China (People's Republic)

    Background/Purpose: Rheumatoid arthritis (RA) is associated with higher cardiovascular disease (CVD) risk due to the underlying inflammation.It is uncertain if the excess CV risk could…
  • Abstract Number: 0283 • ACR Convergence 2021

    Cardiovascular Risk Management in Patients with Rheumatoid Arthritis: A Single-centered Cross-sectional Study

    SAMAR ABOULENAIN1, Khaled Deeb2, Mohamed Abdul Qader1 and Can Jones1, 1University of Miami Miller School, West Palm Beach, FL, 2West Palm Beach VA Medical Center, West Palm Beach, FL

    Background/Purpose: Cardiovascular (CV) disease is the leading cause of death in patients with rheumatoid arthritis (RA) and is estimated to be responsible for 29%-32% of…
  • Abstract Number: 0511 • ACR Convergence 2021

    Tumor Necrosis Factor-α Modulates Endothelial-to-mesenchymal Transition and Increases Protein Tyrosine Phosphatase 1B

    Jorge Romo-Tena1, Jose Esparza-Lopez2, Carmelo Carmona-Rivera3, Luz P blanco3, Mariana Kaplan4 and María de Jesús Ibarra-Sánchez2, 1INNSZ / NIAMS, Mexico City, Mexico, 2INNSZ, Mexico City, Mexico, 3NIAMS, Bethesda, MD, 4National Institutes of Health, Bethesda, MD

    Background/Purpose: Endothelial dysfunction is a hallmark in the pathogenesis of many inflammatory diseases. The endothelial-to-mesenchymal transition (EndoMT) is a process where endothelial cells lose their…
  • Abstract Number: 0708 • ACR Convergence 2021

    Cardiovascular Risk in Myositis Patients Compared to General Population – Preliminary Data from a Single-centre Cross-sectional Study

    Sabina Oreska1, Hana Storkanova1, Maja Spiritovic2, Barbora Hermankova3, Petr Cesak4, Jaroslav Kudlicka5, Vladimir Tuka6, Ondrej Mikes5, Martin Satny5, Eva Chytilova5, Zdislava Krupickova5, Michal Vrablik5, Karel Pavelka1, Ladislav Senolt1, Herman Mann1, Jiri Vencovsky7 and Michal Tomcik1, 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, 3Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, 4Department of Human Movement Laboratory, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 53rd Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 63rd Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charle, Prague, Czech Republic, 7Institute of Rheumatology, Prague, Czech Republic

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are associated with systemic inflammation, limited mobility, and glucocorticoid treatment, which can have a negative impact on metabolic disease, atherogenesis,…
  • Abstract Number: 0855 • ACR Convergence 2021

    Asymptomatic Coronary Artery Disease Assessed by Coronary Computed Tomography in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis

    Claudia Mendoza-Pinto1, Pamela Munguía-Realpozo2, Karla Godinez-Bolaños2, Mario García-Carrasco2, Ivet Etchegaray-Morales2 and Socorro Méndez-Martínez3, 1Instituto Mexicano del Seguro Social, San Andres Cholula, Mexico, 2Benemérita Universidad Autónoma de Puebla, Puebla, Mexico, 3Instituto Mexicano del Seguro Social, Puebla, Mexico

    Background/Purpose: To date, the prevalence and prognosis of coronary artery disease (CAD) according to the coronary calcium score (CCS) and coronary artery calcification (CAC) using…
  • Abstract Number: 0867 • ACR Convergence 2021

    A Proteomic/Transcriptomic Analysis Associates with Subclinical Vascular Disease in Systemic Lupus Erythematosus

    Christopher Oliveira1, Yenealem Temesgen-Oyelakin2, Mohammad Naqi3, Nidhi Patel2, Philip Parel2, Massimo Gadina4, Stefania Dell'Orso2, Stephen Brooks2, Sarthak Gupta5, Nehal Mehta6, Sarfaraz Hasni3 and Mariana Kaplan3, 1National Institutes of Health (NIH), Vienna, VA, 2National Institutes of Health (NIH), Bethesda, MD, 3National Institutes of Health, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 5National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 6NHLBI/National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic lupus erythematosus (SLE) is associated with enhanced cardiovascular (CV) risk linked to both traditional Framingham risk factors and lupus-specific immune dysregulation. Characterizing an…
  • Abstract Number: 1315 • ACR Convergence 2021

    The Best Cardiovascular Risk Algorithm to Predict the Presence of Carotid Plaque in Psoriatic Arthritis Patients

    Natalia Guajardo-Jauregui, Iris Colunga-Pedraza, Jose Azpiri-Lopez, Dionicio Galarza-Delgado, Alejandra Rodriguez-Romero, Diana Flores-Alvarado, Julieta Loya-Acosta, Alejandro Meza-Garza, Jesus Cardenas-de La Garza, Salvador Lugo-Perez and Jessica Castillo-Treviño, Hospital Universitario "Dr Jose E. Gonzalez", Monterrey, Mexico

    Background/Purpose: Systemic inflammation in psoriatic arthritis (PsA) patients accelerates the process of atherosclerosis; this increases the risk of presenting a major cardiovascular (CV) event than…
  • Abstract Number: 1319 • ACR Convergence 2021

    Cardiovascular Risk Reclassification According to Six Traditional Cardiovascular Risk Algorithms and a Carotid Ultrasound in Psoriatic Arthritis Patients

    Natalia Guajardo-Jauregui, Iris Colunga-Pedraza, Jose Azpiri-Lopez, Dionicio Galarza-Delgado, Alejandra Rodriguez-Romero, Diana Flores-Alvarado, Alejandro Meza-Garza, Julieta Loya-Acosta, Jesus Cardenas-de La Garza, Salvador Lugo-Perez, Octavio Ilizaliturri-Guerra, Gisela Garcia-Arellano and Jessica Castillo-Treviño, Hospital Universitario "Dr Jose E. Gonzalez", Monterrey, Mexico

    Background/Purpose: Patients with psoriatic arthritis (PsA) have a higher risk of developing a cardiovascular (CV) event than the general population. This could be attributed to…
  • Abstract Number: 1578 • ACR Convergence 2021

    NLRP3 Inflammasome Pathway Expression at Atheroma Plaques from Peripheral Artery Disease According to the Uricemic Status

    MARIANO ANDRES1, Leticia Mendieta2, Elena Argente-delcastillo1, Miguel Trigueros3 and Alberto Miñano3, 1Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, 2Universidad Miguel Hernández, San Juan de Alicante, Spain, 3Hospital General Universitario de Alicante-ISABIAL, Alicante

    Background/Purpose: Both hyperuricemia and monosodium urate crystals induce persistent inflammation. In vitro, soluble urate can prime innate immune cells and promote NLRP3 inflammasome activation and…
  • Abstract Number: 1330 • ACR Convergence 2020

    Subclinical atherosclertoic disease in ankylosing spondylitis and non-radiographic axial spondyloarthritis. A multicenter study with 806 patients.

    Inigo Gonzalez-Mazon1, Javier Rueda-Gotor2, Ivan Ferraz-Amaro3, Lara Sanchez-Bilbao4, David Martinez-Lopez5, Fernanda Genre6, Natalia Palmou Fontana7, Vanesa Calvo-Río2, Sara Remuzgo-Martínez6, Veronica Pulito-Cueto6, Alfonso Corrales8, Leticia Lera-Gómez6, Virginia Portilla6, Cristina Mata9, Vanesa Hernández-Hernández10, Santos Castañeda11, Esther Francisca Vicente-Rabaneda12, C Fernandez-Carballido13, M Paz Martínez-Vidal14, David Castro-Corredor15, Joaquín Anino-Fernández15, Juan Carlos Quevedo-Abeledo16, Carlos Rodríguez-Lozano17, María Luz García Vivar,18, Eva Galínez-Agirregoikoa18, C. Fernandez-Diaz19, Javier Llorca20, Raquel López-Mejías6, Esther Montes-Perez21, Diana Peiteado22, Chamaida Plasencia23, Alejandro Balsa-Criado24, Nuria Barbarroja25, Lourdes Ladehesa-Pineda26, Rafaela Ortega-Castro27, Eduardo Collantes-Estévez26, Ricardo Blanco28 and Miguel Ángel González-Gay29, 1Hospital Universitario Marques de Valdecilla, Bezana, Spain, 2H.U. Marques de Valdecilla, Santander, Spain, 3Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Spain, 5Hospital Universitario Marques de Valdecilla, Santander (SPAIN), Spain, 6Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic bone Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 7UNIVERSITARY HOSPITAL MARQUES VALDECILLA, Santander, Spain, 8Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic bone diseases of the musculoskeletal system, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 9Hospital de Laredo, Santander, Spain, 10Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 11Princesa University Hospital, Universidad Autónoma, Madrid, Madrid, Spain, 12Hospital Universitario de la Princesa, IIS-Princesa, UAM, Madrid, Madrid, Spain, 13H San Juan, Alicante, Spain, 14Hospital General Universitario de Alicante, Alicante, Spain, 15Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 16Hospital Dr. Negrín, Las Palmas de Gran Canaria, Spain, 17Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain, 18Hospital Universitario Basurto, Bilbao, Spain, 19H. Marqués de Valdecilla, Madrid, Spain, 20School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, 21Diagnóstico Médico Cantabria (DMC), Santander, Spain, 22Hospital Universitario La Paz-IdiPaz, Madrid, Spain, 23Rheumatology, La Paz University Hospital-IdiPAZ, madrid, Spain, 24HOSPITAL UNIVERSITARIO LA PAZ, madrid, Spain, 25Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, 26Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, 27Hospital Universitario Reina Sofía, Córdoba, Spain, 28Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 29Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain

    Background/Purpose: Cardiovascular (CV) mortality and morbidity is increased in ankylosing spondylitits (AS) as compared to the general population. Carotid plaque, considered as a surrogate marker…
  • Abstract Number: 1450 • ACR Convergence 2020

    Integrative Analysis of DNA Methylation and Gene Expression in Monocytes from Primary Antiphospholipid Syndrome Patients Identifies a Gene Expression Signature Associated with Their Atherothrombotic Phenotype

    Carlos Pérez-Sánchez1, M Angeles Aguirre2, Alejandra Maria Patiño-Trives1, Laura Pérez-Sanchez3, Maria Luque-Tevar1, Iván Arias de la Rosa1, María-Carmen Abalos-Aguilera1, Pedro Segui4, Javier Rodriguez-Ubreva5, Esteban Ballestar5, Nuria Barbarroja1, Eduardo Collantes-Estévez2 and Chary Lopez-Pedrera1, 1Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, 2Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, 3Hospital Universitario Reina Sofía, Córdoba, Spain, 4IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, 5Josep Carreras Institute (IJC), Badalona, Spain

    Background/Purpose: 1. To develop integrated analyses of the genome-wide DNA methylation and gene expression profiles in monocytes from APS patients and assess their involvement in…
  • Abstract Number: 1510 • ACR Convergence 2020

    Platelet-bound C4d Is Associated with Platelet Activation and Arterial Thrombotic Events

    Yevgeniya Gartshteyn1, Adam Mor2, Daichi Shimbo2, Leila Khalili3, Teja Kapoor4, Laura Geraldino-Pardilla5, Roberta Vezza Alexander6, Thierry Dervieux7 and Anca Askanase2, 1Columbia University College of Physicians and Surgeons, Glen Rock, NJ, 2Columbia University College of Physicians and Surgeons, New York, NY, 3Columbia University Medical Center, New Haven, CT, 4Columbia University College of Physicians and Surgeons, Leonia, NJ, 5Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, 6Exagen Inc, Vista, CA, 7Prometheus Biosciences Inc, Irvine, CA

    Background/Purpose: Platelets have a well-defined role in arterial thrombosis, and platelet-bound complement activation products (PC4d) correlate with vascular thromboses in patients with Systemic Lupus Erythematosus…
  • Abstract Number: 0191 • ACR Convergence 2020

    Increased Frequency of Lower Limb Arterial Obstruction in Rheumatoid Arthritis

    Ahmed Oglah1, Ali Hussein2, Jose Felix Restrepo3, Carlos Lorenzo3, Agustin Escalante3 and Inmaculada Del Rincon3, 1University of Texas Health Science Center at San Antonio/ Internal Medicine Residency program, San Antonio, TX, 2University of Texas Health Science Center at San Antonio/ Department of Internal Medicine/ Rheumatology, San Antonio, TX, 3University of Texas Health Science Center at San Antonio/ Department of Medicine/ Rheumatology, San Antonio, TX

    Background/Purpose: Despite a high frequency of cardiovascular disease in rheumatoid arthritis (RA), peripheral arterial disease in RA has received little attention. The objective of the…
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