ACR Meeting Abstracts

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Abstracts tagged "Atherosclerosis"

  • Abstract Number: 706 • 2012 ACR/ARHP Annual Meeting

    Excess Mortality From Atherosclerotic Cardiovascular Disease in Systemic Sclerosis Compared to Lupus and Rheumatoid Arthritis

    Amish J. Dave1, Bharathi Lingala2, David Fiorentino3, Eswar Krishnan4 and Lorinda Chung5, 1Stanford University, Stanford, CA, 2Dermatology, Stanford University, Redwood City, CA, 3Dermatology, Stanford University School of Medicine, Redwood City, CA, 4Medicine, Standford University, Palo Alto, CA, 5Rheumatology, Stanford Univ Medical Center, Palo Alto, CA

    Background/Purpose: Patients with autoimmune connective tissue diseases (CTD), including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are at increased risk for atherosclerotic cardiovascular disease…
  • Abstract Number: 1537 • 2012 ACR/ARHP Annual Meeting

    Pathogenesis of Atherosclerosis in   Granulomatosis Polyangiitis

    Rula Hajj-Ali1, Roy L. Silverstein2, Gary S. Hoffman3 and Carol A. Langford4, 1Cleveland Clinic Foundation, Cleveland, OH, 2Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI, 3Rheumatic & Immunologic Dis, Cleveland Clinic Found A50, Cleveland, OH, 4Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Previous studies from our group suggested that the inflammatory events that occur during relapses in patients with Granulomatosis with Polyangiitis (GPA, Wegener’s) may have…
  • Abstract Number: 675 • 2012 ACR/ARHP Annual Meeting

    Differential Impairment of Serum Cholesterol Efflux Capacity in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Pier Luigi Meroni1, Nicoletta Ronda2, Elda Favari3, Orietta Borghi4, Francesca Zimetti5, Mariapia Adorni6, Francesca Ingegnoli7, Maria Gerosa8, Claudia Grossi9 and Franco Bernini6, 1Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, 2Department of Pharmacy, University of Parma, Parma, Italy, 3Department of Pharmacological and Biological Sciences,, University of Parma, Parma, Italy, 4Department of clinical and comunity sciences, University of Milan, Milan, Italy, 5Department of Pharmacological and Biological Sciences, University of Parma, Parma, Italy, 6Department of Pharmacological and Biological Sciences, 39-02-58318176, Parma, Italy, 7Dept. of clinical and community science, Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, 8Department of Clinical Sciences and Community Health, University of Milan, Italy, Division of Rheumatology, Istituto Ortopedico Gaetano Pini,, Milan, Italy, 9Lab of immunology, IRCCS Istituto Auxologico Italiano, Milano, Italy

    Background/Purpose: Accelerated atherosclerosis associated with autoimmune diseases is partly due to immune system dysregulation aggravating cardiovascular damage, but little is known on lipid metabolism derangement…
  • Abstract Number: 1386 • 2012 ACR/ARHP Annual Meeting

    Genetic Variation and Coronary Atherosclerosis in Patients with Systemic Lupus Erythematosus

    Cecilia P. Chung1, Joseph F. Solus2, Annette Oeser3, Chun Li4, Paolo Raggi5, Jeffrey R. Smith3 and C. Michael Stein6, 1Medicine, Vanderbilt University School of Medcine, Nashville, TN, 2Medicine, Vanderbilt University, Nashville, TN, 3Vanderbilt University, Nashville, TN, 4Biostatistics, Vanderbilt University, Nashville, TN, 5University of Alberta, Edmonton, AB, Canada, 6Internal Medicine and Pharmacology, Vanderbilt University, Nashville, TN

    Background/Purpose: Premature coronary artery disease is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). However, this is not explained…
  • Abstract Number: 677 • 2012 ACR/ARHP Annual Meeting

    Antibodies to Oxidized Low Density Lipoprotein or Anti-Lipoprotein Lipase May Lead to More Atherosclerotic Plaque in a Sub-Set of SLE Patients

    Biji T. Kurien1, James Fesmire2, Skyler P. Dillon3, Marianne Reichlin4, Morris Reichlin5 and Robert H. Scofield6, 1College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, 3Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Oklahoma Medical Res Fndn, Oklahoma City, OK, 5Arthritis & Imm Laboratory, Oklahoma Medical Research Foun, Oklahoma City, OK, 6Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose: Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). Oxidized low density lipoproteins (oxLDL) are important in atherosclerosis and have been reported in SLE…
  • Abstract Number: 1258 • 2012 ACR/ARHP Annual Meeting

    Association Between Low Vitamin D Levels and Indicators of Osteoporosis and Atherosclerosis

    Barry J. Sheane1, Ruth Dunne2, Ken Scott3, Mary Hall4, Michelle O'Connor2, Martin Healy5, John Feely4, J.B. Walsh6 and Gaye Cunnane7, 1Dept. of Rheumatology, St. James's Hospital, Dublin, Ireland, 2Diagnostic Imaging Department, St James's Hospital, Dublin, Ireland, 3Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin 8, Ireland, 4Department of Pharmacology and Therapeutics, St James's Hospital, Dublin, Ireland, 5Central Pathology Laboratory, St James's Hospital, Dublin, Ireland, 6Medicine for the Elderly, St James's Hospital, Dublin, Ireland, 7Dept of Rheumatology, St James's Hospital, Dublin, Ireland

    Background/Purpose: Osteoporosis and cardiovascular disease are complications of chronic rheumatoid arthritis (RA). It is not known if these processes share pathogenetic mechanisms. Low levels of…
  • Abstract Number: 681 • 2012 ACR/ARHP Annual Meeting

    Interferon Alpha Decreases Endothelial Nitric Oxide Synthase Function and Expression in Human Umbilical Vein Endothelial Cells

    Joy Buie1 and Jim Oates2, 1Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Premenopausal SLE patients have a devastating increase in cardiovascular disease (CVD) and major associated cardiovascular events (MACE) that are not fully explained by Framingham…
  • Abstract Number: 1259 • 2012 ACR/ARHP Annual Meeting

    Association Between Subclinical Atherosclerosis and Bone Mineral Density in Rheumatoid Arthritis

    Barry J. Sheane1, Ruth Dunne2, Ken Scott3, Mary Hall4, Michelle O'Connor2, Martin Healy5, John Feely4, J.B. Walsh6 and Gaye Cunnane7, 1Rheumatology, St. James Hospital, Dublin, Ireland, 2Diagnostic Imaging Department, St James's Hospital, Dublin 8, Ireland, 3Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin 8, Ireland, 4Department of Pharmacology and Therapeutics, St James's Hospital, Dublin 8, Ireland, 5Central Pathology Laboratory, Dublin 8, Ireland, 6Medicine for the Elderly, Dublin 8, Ireland, 7Dept of Rheumatology, St James's Hospital, Dublin, Ireland

    Background/Purpose: Rheumatoid arthritis (RA) is associated with a higher risk of osteoporosis (OP) and cardiovascular disease (CVD). This cross-sectional study was undertaken to identify links…
  • Abstract Number: 647 • 2012 ACR/ARHP Annual Meeting

    Adjusted Framingham Risk Factor Scoring for Systemic Lupus Erythematosus: Results from an Inception Cohort Followed for Eight Years

    Murray B. Urowitz1, Dominique Ibanez1, D. D. Gladman2, SLICC3 and Systemic Lupus International Collaborating Clinics (SLICC)3, 1Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 3Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose : There is a high prevalence of premature atherosclerosis among patients with SLE, with a risk 7-9  times that of the general population. The…
  • Abstract Number: 1261 • 2012 ACR/ARHP Annual Meeting

    Epicardial Adipose Tissue Is Associated with Cardiometabolic Risk and the Metabolic Syndrome in Patients with Rheumatoid Arthritis

    Michelle J. Ormseth1, Aliza Lipson2, Nikolaos Alexopoulos3, Gregory R. Hartlage3, Annette M. Oeser4, Aihua Bian4, Tebeb Gebretsadik5, Ayumi Shintani4, Paolo Raggi6 and C. Michael Stein7, 1Rheumatology, Vanderbilt Medical Center, Nashville, TN, 2Rheumatology, Emory University, Atlanta, GA, 3Emory University, Atlanta, GA, 4Vanderbilt Medical Center, Nashville, TN, 5Biostatistics, Vanderbilt University, Nashville, TN, 6University of Alberta, Edmonton, AB, Canada, 7School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis and this may be related to their increased prevalence of visceral adiposity, insulin resistance, and…
  • Abstract Number: 629 • 2012 ACR/ARHP Annual Meeting

    Inflammatory Biomarkers of Atherosclerosis and Oxidative Stress Are Associated with Disease Flare in SLE

    Maureen A. McMahon1, Jennifer M. Grossman1, Brian Skaggs2, Elaine Lourenco2, Cheryl Lee1, Lori Sahakian3, John FitzGerald4, Christina Charles-Schoeman5, Alan H. Gorn6, George A. Karpouzas7, Michael H. Weisman8, Daniel J. Wallace9, Weiling Chen1 and Bevra H. Hahn6, 1Div of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 3Division of Rheumatology, Department of Medicine,, UCLA David Geffen School of Medicine, Los Angeles, CA, 4Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 5University of California, Los Angeles, CA, 6Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 7Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 8Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 9Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Although our current serologic measures of disease activity are useful for predicting flare in some patients, other patients experience disease flare in the absence…
  • Abstract Number: 1262 • 2012 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patients with Higher Disease Severity and Subclinical Carotid Plaque Experience More Cardiovascular Events Despite a Favorable Conventional Cadiovascular Risk Profiles

    Yeon-Ah Lee1, Somi Kim1, Sang-Hoon Lee2, Ran Song2, Hyung In Yang2 and Seung-Jae Hong1, 1Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, 2Rheumatology, Hospital at GANGDONG, Kyung Hee University, Seoul, South Korea

    Background/Purpose: It has been shown that patients with rheumatoid arthritis (RA) experience cardiovascular (CV) events more often than expected. Increased risks of CV diseases in…
  • Abstract Number: 596 • 2012 ACR/ARHP Annual Meeting

    Evolution of Atherosclerosis in Psoriatic Arthritis: Is the Former an Independent Inflammatory Process?

    Roberta Ramonda1, Massimo Puato2, Valentina Modesti3, Mariagrazia Lorenzin4, Paola Frallonardo4, Augusta Ortolan4, Carla Campana3, Alessandro Lo Nigro3 and Leonardo Punzi5, 1Rheumatology Unit, University of Padova, Padova, Italy, 2Department of Internal Medicine, University of Padova, Padova, Italy, 3Unit of Rheumatology, University of Padova, Padova, Italy, 4Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, 5Clinical and Experimental Medicine, Rheumatology Unit - University of Padova, Padova, Italy

    Background/Purpose: A non-invasive study focusing on the structural and functional properties of the carotid arteries was carried out in psoriatic arthritis (PsA) patients. Increased cardiovascular…
  • Abstract Number: 1267 • 2012 ACR/ARHP Annual Meeting

    Inflammatory Burden Predicts Progression of Carotid Plaque in Rheumatoid Arthritis: A 24-Month Longitudinal Analysis

    Churl Hyun Im1, Na Ri Kim1, Jong Wan Kang1, Young Ji Kim1, Kyung Hye Kim1, Eon Jeong Nam1 and Young Mo Kang2, 1Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 2Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea

    Background/Purpose: Carotid atherosclerosis, which is associated with the increased risk of cardiovascular (CV) disease, is increased in rheumatoid arthritis (RA) patients. In our previous study,…
  • Abstract Number: 2663 • 2012 ACR/ARHP Annual Meeting

    A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results From a Candidate Gene Study

    Cecilia P. Chung1, Joseph F. Solus2, Annette M. Oeser3, Chun Li4, Paolo Raggi5, Jeffrey R. Smith3 and C. Michael Stein3, 1Medicine, Vanderbilt University, Nashville, TN, 2Medicine, Vanderbilt Medical Center, Nashville, TN, 3Vanderbilt University, Nashville, TN, 4Biostatistics, Vanderbilt University, Nashville, TN, 5Emory University, Atlanta, GA

    Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. However, this association is not fully explained by traditional cardiovascular risk factors or markers of inflammation. Little is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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