Abstracts tagged "Atherosclerosis"

Abstract Number: 1038 • 2012 ACR/ARHP Annual Meeting
Assessment of Aortic Stiffness by Cardiac Magnetic Resonance Imaging in Systemic Autoimmune Rheumatic Diseases
Galia Karp¹, Arik Wolak², Nina Baram³, Victor Novack⁴, Philip Rosen³, Yael Perl⁵, Talia Wolak⁶, Ilan Shelef³ and Mahmoud Abu-Shakra⁷, ¹Medicine and Rheumatology, Department of Medicine, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel, ²Cardiology and and MRI Unit, Dept. of Cardiology, Cardiac MRI unit, Soroka University Medical Center, and Ben Gurion University, Beer-Sheva, Israel, ³Radiology division, Soroka University Medical Center and Ben Gurion University, Radiology division, Soroka University Medical Center and Ben Gurion University, ⁴Department of Medicine and Clinical Research center, Department of Medicine, Clinical Research center, Soroka University Medical Center and Ben Gurion University, ⁵Department of Medicine and Clinical Research center, Clinical Research center, Soroka University Medical Center and Ben Gurion University, ⁶Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, ⁷Medicine and Rheumatology, Department of Medicine and Rheumatology, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel
Background/Purpose: Systemic Lupus Erythematosus (SLE) and rheumatoid arthritis (RA) are known to cause premature arterial aging and early atherosclerosis hence leading to increased stiffness of…
Abstract Number: 1707 • 2012 ACR/ARHP Annual Meeting
The Association of Serum Biomarkers and Metabolic Syndrome with Subclinical Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Analysis in Patients with No Clinical Disease Activity
Semra Ertan-Demir¹, Ahmet Yasar Cizgici², Gaye Erten³, Bahar Artim-Esen⁴, Yasemin Sahinkaya⁴, Özlem Pehlivan⁴, Nilüfer Alpay-Kanitez⁴, Kadri Atay¹, Huseyin Oflaz², Gunnur Deniz³ and Murat Inanc⁴, ¹Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Cardiology Department, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Immunology, Istanbul University, Institute of Experimental Medicine (DETAE), Istanbul, Turkey, ⁴Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing atherosclerotic cardiovascular disease (CVD). In addition to traditional CVD risk factors or…
Abstract Number: 991 • 2012 ACR/ARHP Annual Meeting
MTHFR Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Associations with Intima Media Thickness Scores
Clio P. Mavragani¹, Maira Giannelou², Ioanna Papadaki³, Eleni Antypa⁴, Dimitrios Ioakeimidis⁵, Haralampos M. Moutsopoulos² and Michael Koutsilieris⁶, ¹Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ²Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ³Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, ⁴Department of Radiology, General Hospital of Athens, Greece, ⁵Department of Rheumatology, General Hospital, Greece, ⁶Department of Physiology, Athens University Medical School, Athens, Greece
Background/Purpose: Previous studies identified polymorphisms in the gene coding for the Methylenetetrahydrofolatereductase (MTHFR) enzyme as genetic contributors for cardiovascular disease in the general population. The…
Abstract Number: 1664 • 2012 ACR/ARHP Annual Meeting
Autoantibodies Are Associated with Subclinical Atherosclerosis and Cardiovascular Endpoints in Caucasian and African American Women in a Prospective Study: the Multi-Ethnic Study of Atherosclerosis (MESA)
Darcy S. Majka¹, Rowland W. Chang², Richard M. Pope³, Marius C. Teodorescu⁴, Elizabeth W. Karlson⁵, Thanh Huyen T. Vu⁶, Joseph Kang⁶ and Kiang Liu⁷, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²Dept Preventive Med, Northwestern University, Chicago, IL, ³Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ⁴Microbiology, TheraTest Laboratories Inc, Lombard, IL, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁷Preventive Medicine, Northwestern University, Chicago, IL
Background/Purpose: Although the association between rheumatoid arthritis (RA) and cardiovascular disease (CVD) is established, the exact mechanism is not known. Subjects who later develop RA…
Abstract Number: 706 • 2012 ACR/ARHP Annual Meeting
Excess Mortality From Atherosclerotic Cardiovascular Disease in Systemic Sclerosis Compared to Lupus and Rheumatoid Arthritis
Amish J. Dave¹, Bharathi Lingala², David Fiorentino³, Eswar Krishnan⁴ and Lorinda Chung⁵, ¹Stanford University, Stanford, CA, ²Dermatology, Stanford University, Redwood City, CA, ³Dermatology, Stanford University School of Medicine, Redwood City, CA, ⁴Medicine, Standford University, Palo Alto, CA, ⁵Rheumatology, Stanford Univ Medical Center, Palo Alto, CA
Background/Purpose: Patients with autoimmune connective tissue diseases (CTD), including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are at increased risk for atherosclerotic cardiovascular disease…
Abstract Number: 1537 • 2012 ACR/ARHP Annual Meeting
Pathogenesis of Atherosclerosis in Granulomatosis Polyangiitis
Rula Hajj-Ali¹, Roy L. Silverstein², Gary S. Hoffman³ and Carol A. Langford⁴, ¹Cleveland Clinic Foundation, Cleveland, OH, ²Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI, ³Rheumatic & Immunologic Dis, Cleveland Clinic Found A50, Cleveland, OH, ⁴Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH
Background/Purpose: Previous studies from our group suggested that the inflammatory events that occur during relapses in patients with Granulomatosis with Polyangiitis (GPA, Wegener’s) may have…
Abstract Number: 675 • 2012 ACR/ARHP Annual Meeting
Differential Impairment of Serum Cholesterol Efflux Capacity in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Pier Luigi Meroni¹, Nicoletta Ronda², Elda Favari³, Orietta Borghi⁴, Francesca Zimetti⁵, Mariapia Adorni⁶, Francesca Ingegnoli⁷, Maria Gerosa⁸, Claudia Grossi⁹ and Franco Bernini⁶, ¹Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, ²Department of Pharmacy, University of Parma, Parma, Italy, ³Department of Pharmacological and Biological Sciences,, University of Parma, Parma, Italy, ⁴Department of clinical and comunity sciences, University of Milan, Milan, Italy, ⁵Department of Pharmacological and Biological Sciences, University of Parma, Parma, Italy, ⁶Department of Pharmacological and Biological Sciences, 39-02-58318176, Parma, Italy, ⁷Dept. of clinical and community science, Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, ⁸Department of Clinical Sciences and Community Health, University of Milan, Italy, Division of Rheumatology, Istituto Ortopedico Gaetano Pini,, Milan, Italy, ⁹Lab of immunology, IRCCS Istituto Auxologico Italiano, Milano, Italy
Background/Purpose: Accelerated atherosclerosis associated with autoimmune diseases is partly due to immune system dysregulation aggravating cardiovascular damage, but little is known on lipid metabolism derangement…
Abstract Number: 1386 • 2012 ACR/ARHP Annual Meeting
Genetic Variation and Coronary Atherosclerosis in Patients with Systemic Lupus Erythematosus
Cecilia P. Chung¹, Joseph F. Solus², Annette Oeser³, Chun Li⁴, Paolo Raggi⁵, Jeffrey R. Smith³ and C. Michael Stein⁶, ¹Medicine, Vanderbilt University School of Medcine, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵University of Alberta, Edmonton, AB, Canada, ⁶Internal Medicine and Pharmacology, Vanderbilt University, Nashville, TN
Background/Purpose: Premature coronary artery disease is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). However, this is not explained…
Abstract Number: 677 • 2012 ACR/ARHP Annual Meeting
Antibodies to Oxidized Low Density Lipoprotein or Anti-Lipoprotein Lipase May Lead to More Atherosclerotic Plaque in a Sub-Set of SLE Patients
Biji T. Kurien¹, James Fesmire², Skyler P. Dillon³, Marianne Reichlin⁴, Morris Reichlin⁵ and Robert H. Scofield⁶, ¹College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, ³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Oklahoma Medical Res Fndn, Oklahoma City, OK, ⁵Arthritis & Imm Laboratory, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁶Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). Oxidized low density lipoproteins (oxLDL) are important in atherosclerosis and have been reported in SLE…
Abstract Number: 1258 • 2012 ACR/ARHP Annual Meeting
Association Between Low Vitamin D Levels and Indicators of Osteoporosis and Atherosclerosis
Barry J. Sheane¹, Ruth Dunne², Ken Scott³, Mary Hall⁴, Michelle O'Connor², Martin Healy⁵, John Feely⁴, J.B. Walsh⁶ and Gaye Cunnane⁷, ¹Dept. of Rheumatology, St. James's Hospital, Dublin, Ireland, ²Diagnostic Imaging Department, St James's Hospital, Dublin, Ireland, ³Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin 8, Ireland, ⁴Department of Pharmacology and Therapeutics, St James's Hospital, Dublin, Ireland, ⁵Central Pathology Laboratory, St James's Hospital, Dublin, Ireland, ⁶Medicine for the Elderly, St James's Hospital, Dublin, Ireland, ⁷Dept of Rheumatology, St James's Hospital, Dublin, Ireland
Background/Purpose: Osteoporosis and cardiovascular disease are complications of chronic rheumatoid arthritis (RA). It is not known if these processes share pathogenetic mechanisms. Low levels of…
Abstract Number: 681 • 2012 ACR/ARHP Annual Meeting
Interferon Alpha Decreases Endothelial Nitric Oxide Synthase Function and Expression in Human Umbilical Vein Endothelial Cells
Joy Buie¹ and Jim Oates², ¹Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Premenopausal SLE patients have a devastating increase in cardiovascular disease (CVD) and major associated cardiovascular events (MACE) that are not fully explained by Framingham…
Abstract Number: 1259 • 2012 ACR/ARHP Annual Meeting
Association Between Subclinical Atherosclerosis and Bone Mineral Density in Rheumatoid Arthritis
Barry J. Sheane¹, Ruth Dunne², Ken Scott³, Mary Hall⁴, Michelle O'Connor², Martin Healy⁵, John Feely⁴, J.B. Walsh⁶ and Gaye Cunnane⁷, ¹Rheumatology, St. James Hospital, Dublin, Ireland, ²Diagnostic Imaging Department, St James's Hospital, Dublin 8, Ireland, ³Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin 8, Ireland, ⁴Department of Pharmacology and Therapeutics, St James's Hospital, Dublin 8, Ireland, ⁵Central Pathology Laboratory, Dublin 8, Ireland, ⁶Medicine for the Elderly, Dublin 8, Ireland, ⁷Dept of Rheumatology, St James's Hospital, Dublin, Ireland
Background/Purpose: Rheumatoid arthritis (RA) is associated with a higher risk of osteoporosis (OP) and cardiovascular disease (CVD). This cross-sectional study was undertaken to identify links…
Abstract Number: 647 • 2012 ACR/ARHP Annual Meeting
Adjusted Framingham Risk Factor Scoring for Systemic Lupus Erythematosus: Results from an Inception Cohort Followed for Eight Years
Murray B. Urowitz¹, Dominique Ibanez¹, D. D. Gladman², SLICC³ and Systemic Lupus International Collaborating Clinics (SLICC)³, ¹Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose : There is a high prevalence of premature atherosclerosis among patients with SLE, with a risk 7-9 times that of the general population. The…
Abstract Number: 1261 • 2012 ACR/ARHP Annual Meeting
Epicardial Adipose Tissue Is Associated with Cardiometabolic Risk and the Metabolic Syndrome in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Aliza Lipson², Nikolaos Alexopoulos³, Gregory R. Hartlage³, Annette M. Oeser⁴, Aihua Bian⁴, Tebeb Gebretsadik⁵, Ayumi Shintani⁴, Paolo Raggi⁶ and C. Michael Stein⁷, ¹Rheumatology, Vanderbilt Medical Center, Nashville, TN, ²Rheumatology, Emory University, Atlanta, GA, ³Emory University, Atlanta, GA, ⁴Vanderbilt Medical Center, Nashville, TN, ⁵Biostatistics, Vanderbilt University, Nashville, TN, ⁶University of Alberta, Edmonton, AB, Canada, ⁷School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis and this may be related to their increased prevalence of visceral adiposity, insulin resistance, and…
Abstract Number: 629 • 2012 ACR/ARHP Annual Meeting
Inflammatory Biomarkers of Atherosclerosis and Oxidative Stress Are Associated with Disease Flare in SLE
Maureen A. McMahon¹, Jennifer M. Grossman¹, Brian Skaggs², Elaine Lourenco², Cheryl Lee¹, Lori Sahakian³, John FitzGerald⁴, Christina Charles-Schoeman⁵, Alan H. Gorn⁶, George A. Karpouzas⁷, Michael H. Weisman⁸, Daniel J. Wallace⁹, Weiling Chen¹ and Bevra H. Hahn⁶, ¹Div of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Division of Rheumatology, Department of Medicine,, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁵University of California, Los Angeles, CA, ⁶Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁷Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Although our current serologic measures of disease activity are useful for predicting flare in some patients, other patients experience disease flare in the absence…

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