ACR Meeting Abstracts

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Abstracts tagged "Atherosclerosis"

  • Abstract Number: 1252 • 2012 ACR/ARHP Annual Meeting

    Association of Paraoxonase 1 Gene Polymorphisms and Enzyme Activity with Carotid Plaque in Rheumatoid Arthritis

    Christina Charles-Schoeman1, Yuen Yin Lee1, Veena K. Ranganath1, John FitzGerald1, Mihaela B. Taylor2, Maureen A. McMahon1, David Elashoff3 and Srinivasa T. Reddy4, 1University of California, Los Angeles, CA, 2University of California, Los Angeles, Los Angeles, CA, 3Medicine- Statistic Core, UCLA Department of Medicine Statistics Core, Los Angeles, CA, 4Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme, which promotes the anti-oxidant and anti-inflammatory properties of HDL.  PON1 polymorphisms and enzyme…
  • Abstract Number: 1253 • 2012 ACR/ARHP Annual Meeting

    Identifying Vulnerable Plaque in Rheumatoid Arthritis:  A Pilot Study Using Novel Microbubble-Contrast Enhanced Carotid Ultrasonography

    Kimberly P. Liang1, Douglas P. Landsittel2, Suresh R. Mulukutla3, Steven E. Reis4, Marc C. Levesque1, Flordeliza S. Villanueva3, Hunter C. Champion5 and Larry W. Moreland1, 1Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, 3Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, 4Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, 5Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD). Markers of systemic inflammation, as seen in RA, are associated…
  • Abstract Number: 1255 • 2012 ACR/ARHP Annual Meeting

    Vascular Calcification On Hand and Feet X-Rays, VFA Imaging of the Spine, and Cardiovascular Disease in Rheumatoid Arthritis

    Ausaf Mohammad1, Collette English2, Derek Lohan2, Diane Bergin2, Sarah Mooney2, John Newell3, Martin O'Donnell4, Robert J. Coughlan1 and John J. Carey1, 1Rheumatology, Galway University Hospitals, Galway, Ireland, 2Radiology, Galway University Hospitals, Galway, Ireland, 3Clinical Research Facility, National University of Ireland, Galway, Ireland, 4Clinical Research Facility, Galway University Hospitals, Galway, Ireland

    Vascular Calcification on Hand and Feet X-rays, VFA imaging of the spine, and Cardiovascular Disease in Rheumatoid ArthritisBackground/Purpose: Patients with rheumatoid arthritis (RA) are at…
  • Abstract Number: 1205 • 2012 ACR/ARHP Annual Meeting

    Study of Association of CD40-CD154 Gene Polymorphisms with Disease Susceptibility and Cardiovascular Risk in Spanish Rheumatoid Arthritis Patients

    Mercedes García-Bermúdez1, Carlos González-Juanatey2, Alfonso Corrales3, Raquel López-Mejías4, Maria Teruel5, Jose A. Miranda-Filloy6, Santos Castañeda-Sanz7, Alejandro Balsa8, B. Fernández-Gutierrez9, Isidoro González-Álvaro10, Carmen Gómez-Vaquero11, R. Blanco Alonso12, Javier Llorca13, Javier Martin14 and Miguel Angel González-Gay4, 1Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 2Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, 3Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 5Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 6Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 7Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain, 8Rheumatology, La Paz Hospital. IdiPaz, Madrid, Spain, 9Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 10Servicio de Reumatología, Reumatología (Hospital Universitario de La Princesa), Madrid, Spain, 11Rheumatology Service, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, 12Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, 13Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, 14Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Since CD40-CD154 binding has direct consequences on inflammation process initiation,…
  • Abstract Number: 2272 • 2012 ACR/ARHP Annual Meeting

    Gene Expression Signatures in Monocytes From Primary Antiphospholipd Syndrome, Systemic Lupus Erythematosus and Lupus with Antiphospholipid Syndrome Identify Specific Pathways Involved in the Pathogenesis of Atherosclerosis and Cardiovascular Disease

    Chary Lopez-Pedrera1, Sebastiano Messineo2, Carlos Perez-Sanchez1, Patricia Ruiz-Limon1, Mª Angeles Aguirre3, Rosario M. Carretero-Prieto4, Antonio Rodriguez-Ariza1, Nuria Barbarroja4, Francisco Velasco1, Munther A. Khamashta5, Eduardo Collantes-Estevez1 and Mª Jose Cuadrado6, 1IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 2Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Italy., Catanzaro, Italy, 3Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 4Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, 5Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, 6Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom

    Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by immune-mediated inflammation in multiple organ systems. SLE, primary Antiphospholipid syndrome (APS) and secondary APS (SAPS) share several…
  • Abstract Number: 1211 • 2012 ACR/ARHP Annual Meeting

    ANTI-Cyclic Citrullinated Protein Antibodies Induce Inflammation and Oxidative Stress in WHITE Blood CELLS of Rheumatoid Arthritis Patients

    Chary Lopez-Pedrera1, Carlos Perez-Sanchez1, Patricia Ruiz-Limon1, Mª Angeles Aguirre2, Rosario M. Carretero-Prieto1, Antonio Rodriguez-Ariza3, Nuria Barbarroja1, Pilar Font1, Francisco Martinez2, Inmaculada Gomez-Gracia2, Mª Jose Cuadrado4 and Eduardo Collantes-Estevez2, 1Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, 2Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 3Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 4Lupus Research Unit, The Rayne Institute, London, United Kingdom

    Background/Purpose: Anti-cyclic citrulinated protein antibodies (anti-CCP) are the most specific autoantibody markers in rheumatoid arthritis (RA) patients. However no previous studies have evaluated their role…
  • Abstract Number: 2078 • 2012 ACR/ARHP Annual Meeting

    Low-Density Lipoprotein Receptor Deficiency Ameliorates the Development of Inflammatory Arthritis

    Shawn Rose1 and Harris R. Perlman2, 1Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL

    Background/Purpose: Patients with rheumatoid arthritis (RA) carry a higher risk of cardiovascular disease compared to the general population.  The low-density lipoprotein receptor (LDLR) and Apolipoprotein…
  • Abstract Number: 1038 • 2012 ACR/ARHP Annual Meeting

    Assessment of Aortic Stiffness by Cardiac Magnetic Resonance Imaging in Systemic Autoimmune Rheumatic Diseases

    Galia Karp1, Arik Wolak2, Nina Baram3, Victor Novack4, Philip Rosen3, Yael Perl5, Talia Wolak6, Ilan Shelef3 and Mahmoud Abu-Shakra7, 1Medicine and Rheumatology, Department of Medicine, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel, 2Cardiology and and MRI Unit, Dept. of Cardiology, Cardiac MRI unit, Soroka University Medical Center, and Ben Gurion University, Beer-Sheva, Israel, 3Radiology division, Soroka University Medical Center and Ben Gurion University, Radiology division, Soroka University Medical Center and Ben Gurion University, 4Department of Medicine and Clinical Research center, Department of Medicine, Clinical Research center, Soroka University Medical Center and Ben Gurion University, 5Department of Medicine and Clinical Research center, Clinical Research center, Soroka University Medical Center and Ben Gurion University, 6Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, 7Medicine and Rheumatology, Department of Medicine and Rheumatology, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel

    Background/Purpose: Systemic Lupus Erythematosus (SLE) and rheumatoid arthritis (RA) are known to cause premature arterial aging and early atherosclerosis hence leading to increased stiffness of…
  • Abstract Number: 1707 • 2012 ACR/ARHP Annual Meeting

    The Association of Serum Biomarkers and Metabolic Syndrome with Subclinical Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Analysis in Patients with No Clinical Disease Activity

    Semra Ertan-Demir1, Ahmet Yasar Cizgici2, Gaye Erten3, Bahar Artim-Esen4, Yasemin Sahinkaya4, Özlem Pehlivan4, Nilüfer Alpay-Kanitez4, Kadri Atay1, Huseyin Oflaz2, Gunnur Deniz3 and Murat Inanc4, 1Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Cardiology Department, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 3Department of Immunology, Istanbul University, Institute of Experimental Medicine (DETAE), Istanbul, Turkey, 4Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing atherosclerotic cardiovascular disease (CVD). In addition to traditional CVD risk factors or…
  • Abstract Number: 991 • 2012 ACR/ARHP Annual Meeting

    MTHFR Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Associations with Intima Media Thickness Scores

    Clio P. Mavragani1, Maira Giannelou2, Ioanna Papadaki3, Eleni Antypa4, Dimitrios Ioakeimidis5, Haralampos M. Moutsopoulos2 and Michael Koutsilieris6, 1Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, 2Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, 3Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, 4Department of Radiology, General Hospital of Athens, Greece, 5Department of Rheumatology, General Hospital, Greece, 6Department of Physiology, Athens University Medical School, Athens, Greece

    Background/Purpose: Previous studies identified polymorphisms in the gene coding for the Methylenetetrahydrofolatereductase (MTHFR) enzyme as genetic contributors for cardiovascular disease in the general population. The…
  • Abstract Number: 1664 • 2012 ACR/ARHP Annual Meeting

    Autoantibodies Are Associated with Subclinical Atherosclerosis and Cardiovascular Endpoints in Caucasian and African American Women in a Prospective Study:  the Multi-Ethnic Study of Atherosclerosis (MESA)

    Darcy S. Majka1, Rowland W. Chang2, Richard M. Pope3, Marius C. Teodorescu4, Elizabeth W. Karlson5, Thanh Huyen T. Vu6, Joseph Kang6 and Kiang Liu7, 1Division of Rheumatology, Northwestern University, Chicago, IL, 2Dept Preventive Med, Northwestern University, Chicago, IL, 3Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, 4Microbiology, TheraTest Laboratories Inc, Lombard, IL, 5Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 7Preventive Medicine, Northwestern University, Chicago, IL

    Background/Purpose: Although the association between rheumatoid arthritis (RA) and cardiovascular disease (CVD) is established, the exact mechanism is not known. Subjects who later develop RA…
  • Abstract Number: 706 • 2012 ACR/ARHP Annual Meeting

    Excess Mortality From Atherosclerotic Cardiovascular Disease in Systemic Sclerosis Compared to Lupus and Rheumatoid Arthritis

    Amish J. Dave1, Bharathi Lingala2, David Fiorentino3, Eswar Krishnan4 and Lorinda Chung5, 1Stanford University, Stanford, CA, 2Dermatology, Stanford University, Redwood City, CA, 3Dermatology, Stanford University School of Medicine, Redwood City, CA, 4Medicine, Standford University, Palo Alto, CA, 5Rheumatology, Stanford Univ Medical Center, Palo Alto, CA

    Background/Purpose: Patients with autoimmune connective tissue diseases (CTD), including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are at increased risk for atherosclerotic cardiovascular disease…
  • Abstract Number: 1537 • 2012 ACR/ARHP Annual Meeting

    Pathogenesis of Atherosclerosis in   Granulomatosis Polyangiitis

    Rula Hajj-Ali1, Roy L. Silverstein2, Gary S. Hoffman3 and Carol A. Langford4, 1Cleveland Clinic Foundation, Cleveland, OH, 2Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI, 3Rheumatic & Immunologic Dis, Cleveland Clinic Found A50, Cleveland, OH, 4Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Previous studies from our group suggested that the inflammatory events that occur during relapses in patients with Granulomatosis with Polyangiitis (GPA, Wegener’s) may have…
  • Abstract Number: 675 • 2012 ACR/ARHP Annual Meeting

    Differential Impairment of Serum Cholesterol Efflux Capacity in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Pier Luigi Meroni1, Nicoletta Ronda2, Elda Favari3, Orietta Borghi4, Francesca Zimetti5, Mariapia Adorni6, Francesca Ingegnoli7, Maria Gerosa8, Claudia Grossi9 and Franco Bernini6, 1Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, 2Department of Pharmacy, University of Parma, Parma, Italy, 3Department of Pharmacological and Biological Sciences,, University of Parma, Parma, Italy, 4Department of clinical and comunity sciences, University of Milan, Milan, Italy, 5Department of Pharmacological and Biological Sciences, University of Parma, Parma, Italy, 6Department of Pharmacological and Biological Sciences, 39-02-58318176, Parma, Italy, 7Dept. of clinical and community science, Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, 8Department of Clinical Sciences and Community Health, University of Milan, Italy, Division of Rheumatology, Istituto Ortopedico Gaetano Pini,, Milan, Italy, 9Lab of immunology, IRCCS Istituto Auxologico Italiano, Milano, Italy

    Background/Purpose: Accelerated atherosclerosis associated with autoimmune diseases is partly due to immune system dysregulation aggravating cardiovascular damage, but little is known on lipid metabolism derangement…
  • Abstract Number: 1386 • 2012 ACR/ARHP Annual Meeting

    Genetic Variation and Coronary Atherosclerosis in Patients with Systemic Lupus Erythematosus

    Cecilia P. Chung1, Joseph F. Solus2, Annette Oeser3, Chun Li4, Paolo Raggi5, Jeffrey R. Smith3 and C. Michael Stein6, 1Medicine, Vanderbilt University School of Medcine, Nashville, TN, 2Medicine, Vanderbilt University, Nashville, TN, 3Vanderbilt University, Nashville, TN, 4Biostatistics, Vanderbilt University, Nashville, TN, 5University of Alberta, Edmonton, AB, Canada, 6Internal Medicine and Pharmacology, Vanderbilt University, Nashville, TN

    Background/Purpose: Premature coronary artery disease is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). However, this is not explained…
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