Abstracts tagged "AS"

Abstract Number: 1619 • 2018 ACR/ARHP Annual Meeting
Patterns and Outcomes on As Patients Disease Activity Using Smart System of Disease Management (SSDM): Analysis of T2T Pattern Shift and the Correlation between Disease Activity and Mental Health
Jing Xue¹, Hui Song², Jing Yang³, Zhenchun Zhang⁴, Chun Li⁵, Hongbin Li⁶, Zhenbiao Wu⁷, Hua Wei⁸, Jianlin Huang⁹, Hongzhi Wang¹⁰, Yasong Li¹¹, Xiaohan Wang¹², Henglian Wu¹³, Miaojia Zhang¹⁴, Yuhua Jia¹⁵, Hui Xiao¹⁵, Fei Xiao¹⁵ and Huaxiang Wu¹⁶, ¹88 Jiefang Road, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, ²Department of Rheumatology, Beijing Jishuitan Hospital, Beijing, China, ³Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, ⁴People's Hospital of Linyi, Shandong, Linyi, China, ⁵Peking University People's Hospital, Beijing, China, ⁶The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, ⁷The First Affiliated Hospital of The Fourth Military Medical University, Xi'an, China, ⁸Northern Jiangsu People's Hospital, Yangzhou, China, ⁹Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China, ¹⁰The First Hospital of Jiaxing, Jiaxing, China, ¹¹Department of Rheumatology and Immunology, Zhejiang Provincal People's Hospital, Hangzhou, China, ¹²Department of Rheumatology and Immunology, Anyang district hospital, Anyang, China, ¹³Dongguan Donghua Hospital, Dongguan, China, ¹⁴Department of Rheumatology and Immunology, Jiangsu Province Hospital, Nanjing, China, ¹⁵Shanghai Gothic Internet Technology Co., Ltd., Shanghai, China, ¹⁶The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Background/Purpose: Ankylosing Spondylitis Disease Activity Score (ASDAS) was adopted to evaluate the degree of disease activity and the inflammatory response in AS patients. ASDAS score…
Abstract Number: 580 • 2017 ACR/ARHP Annual Meeting
Tenascin-C, a TLR 4 Endogenous Ligand Levels Are Increased in Ankylosing Spondylitis
Latika Gupta, Shruti Bhattacharya and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Monocytes of patients with Ankylosing Spondylitis (AS) over-express Toll-like receptor (TLR) 4 on their monocytes. Tenascin-C (TNC) is an extracellular-matrix-glycoprotein and acts as an…
Abstract Number: 1001 • 2017 ACR/ARHP Annual Meeting
Persistence, Discontinuation, and Switching Patterns Among Ankylosing Spondylitis Patients Newly Initiating Biologic Therapy
Theresa Hunter¹, Krista Schroeder², Sarah Al Sawah² and David Sandoval Calderon², ¹Global Patient Outcomes and Real World Evidence, Eli Lilly and Company, Indianapolis, IN, ²Eli Lilly and Company, Indianapolis, IN
Background/Purpose: The primary goals of treating Ankylosing Spondylitis (AS) patients are to maximize long-term health-related quality of life through control of symptoms and inflammation, prevention…
Abstract Number: 679 • 2016 ACR/ARHP Annual Meeting
Diagnostic Value of MR Enterography As a Complementary Intervention to Colonoscopy in Axial Spondylarthritis Patients with Chronic Non-Bloody Diarrhea
Ilkay Ergenç¹, Ali Ugur Unal², Zeynep Erturk³, Gulsum Oguz⁴, Yasemin Yalcinkaya⁵, Nese Imeryuz⁶, Rabia Ergelen⁷, Gazanfer Ekinci⁸, Nevsun Inanc⁵, Cigdem Celikel⁹, Haner Direskeneli¹⁰, Hakan Akin¹¹ and Pamir Atagunduz⁵, ¹Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey, ²Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ³Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ⁵Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁶Gastroenterology, Marmara University, Istanbul, Turkey, ⁷Radiology, Marmara University School of Medicine, Istanbul, Turkey, ⁸Marmara University Faculty of Medicine Department of Radiology, Istanbul, Turkey, ⁹Pathology, Marmara University School of Medicine, Istanbul, Turkey, ¹⁰Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ¹¹Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey
Background/Purpose: Chronic intermittent diarrhea (CID) is a common clinical problem in axial spondylarthritis (axSpA) patients and eventually up to 13% of these are diagnosed with…
Abstract Number: 699 • 2016 ACR/ARHP Annual Meeting
In Contrast to Men, Women with Nonradiographic Axial Spondyloarthritis Have Lower Response Rates to TNF Inhibitors Than Women with Ankylosing Spondylitis
Adrian Ciurea¹, Monika Hebeisen², Ulrich Weber^3,4, Giorgio Tamborrini⁵, Raphael Micheroli¹, Lukas Wildi¹, Pascal Zufferey⁶, Michael J. Nissen⁷, Peter M. Villiger⁸, Juerg Bernhard⁹, Désirée van der Heijde¹⁰, RBM Landewé^11,12, Almut Scherer² and Pascale Exer¹³, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²SCQM Foundation, Zurich, Switzerland, ³Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, ⁴Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ⁵Department of Rheumatology and Musculoskeletal Ultrasound, Bethesda Hospital Basel, Basel, Switzerland, ⁶Rheumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, ⁷Rheumatology, Geneva University Hospital, Geneva, Switzerland, ⁸Rheumatology, Clinical immunology & Alllergology, University Hospital Bern, Bern, Switzerland, ⁹Rheumatology Center, Buergerspital, Solothurn, Switzerland, ¹⁰Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹¹Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ¹²Zuyderland Medical Center, Heerlen, Netherlands, Heerlen, Netherlands, ¹³Private rheumatology practice, Basel, Switzerland
Background/Purpose: Response to tumor necrosis factor inhibition (TNFi) has been shown to be similar in nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) in patients…
Abstract Number: 2706 • 2016 ACR/ARHP Annual Meeting
Elevated Levels of Serum Myeloid Related Protein 8/14 in Ankylosing Spondylitis: Associated with Peripheral Arthritis and Active Disease
Latika Gupta¹, Shruti Bhattacharya¹, Vikas Agarwal² and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²clinical Immunology, sanjay Gandhi Postgraduate Institute of Medical Sciences, lucknow, India
Background/Purpose: Monocytes of patients with Ankylosing Spondylitis (AS) show Toll-like receptor 4 (TLR4) over-expression. Myeloid-related proteins (MRP) 8/14 protein complexes are calcium-binding proteins, which act…
Abstract Number: 2755 • 2016 ACR/ARHP Annual Meeting
Comparison of Clinical Profile of Geriatric and Non-Geriatric Ankylosing Spondylitis (AS) Patients
Ahmed Omar¹, Laura Passalent², Renise Ayearst³, Ismail Sari¹, Anthony V. Perruccio⁴, Rajiv Gandhi⁵, Nigil Haroon¹ and Robert D Inman¹, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ²Allied Health, Toronto Western Hospital, Toronto, ON, Canada, ³Medicine, University Health Network, Toronto, ON, Canada, ⁴Health Care & Outcomes Research, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁵Department of Surgery - Orthopedics, Toronto Western Hospital, Assistant Professor, Department of Surgery, University of Toronto, Toronto, ON, Canada
Background/Purpose: Data on disease characteristics of geriatric patients (>=65 years) with AS are lacking. The objective of this study is to compare: 1) the clinical…
Abstract Number: 681 • 2015 ACR/ARHP Annual Meeting
Impact of Disease Duration on Patient Reported and Clinical Outcomes in Patients with Ankylosing Spondylitis Treated with Anti-TNF: An Analysis from a Prospective, Observational Registry
Michael Starr¹, Michel Zummer², Denis Choquette³, Boulos Haraoui⁴, Dalton Sholter⁵, Regan Arendse⁶, Isabelle Fortin⁷, Louis Bessette⁸, Proton Rahman⁹, Emmanouil Rampakakis¹⁰, Eliofotisti Psaradellis¹¹, Allen J Lehman¹², Karina Maslova¹², Brendan Osborne¹³, Francois Nantel^14,15 and Cathy Tkaczyk¹³, ¹Rheumatology, McGill University, Montreal, QC, Canada, ²Rheumatology, Hôpital Maisonneuve-Rosemont and University of Montreal, Montreal, QC, Canada, ³Rheumatology Department, Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁴Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁵Rheumatology Associates, Edmonton, AB, Canada, ⁶University of Saskatchewan, Saskatoon, SK, Canada, ⁷Centre de Rhumatologie de l'Est du Québec, Rimouski, QC, Canada, ⁸Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, ⁹Medicine, Memorial University, St John's, NF, Canada, ¹⁰JSS Medical Research, St-Laurent, QC, Canada, ¹¹JSS Medical Research, Montreal, QC, Canada, ¹²Janssen Inc., Toronto, ON, Canada, ¹³Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹⁴Schering Plough Canada Inc., Janssen Inc., Kirkland, QC, QC, Canada, ¹⁵19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Previous studies have shown that treatment outcomes are affected by disease-related aspects (e.g., disease severity and chronicity, treatment type and intensity) and patient-related factors…
Abstract Number: 711 • 2015 ACR/ARHP Annual Meeting
Gender Specific Differences in Ankylosing Spondylitis at Treatment Initiation in Patients Treated with Infliximab or Golimumab
Michael Starr¹, Michel Zummer², Denis Choquette³, Boulos Haraoui⁴, Proton Rahman⁵, Maqbool Sheriff⁶, Niall Jones⁷, Emmanouil Rampakakis⁸, Eliofotisti Psaradellis⁹, Brendan Osborne¹⁰, Allen J Lehman^10,11, Karina Maslova¹¹, Francois Nantel^12,13 and Cathy Tkaczyk¹⁰, ¹Rheumatology, McGill University, Montreal, QC, Canada, ²Rheumatology, Hôpital Maisonneuve-Rosemont and University of Montreal, Montreal, QC, Canada, ³Rheumatology Department, Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁴Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁵Medicine, Memorial University, St John's, NF, Canada, ⁶Nanaimo Regional General Hospital, Nanaimo, BC, Canada, ⁷Division of Rheumatology, University of Alberta, Edmonton, AB, Canada, ⁸JSS Medical Research, St-Laurent, QC, Canada, ⁹JSS Medical Research, Montreal, QC, Canada, ¹⁰Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹¹Janssen Inc., Toronto, ON, Canada, ¹²Schering Plough Canada Inc., Janssen Inc., Kirkland, QC, QC, Canada, ¹³19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: The prevalence of ankylosing spondylitis (AS) is 2-3 times higher in men compared to women. Recent studies have suggested that clinical differences exist between…
Abstract Number: 2879 • 2015 ACR/ARHP Annual Meeting
What Is the Location of Dactylitis in Ankylosing Spondylitis and Psoriatic Arthritis Patients and How Do They Respond to Anti-TNF Treatment?
Regan Arendse¹, Proton Rahman², Denis Choquette³, J Antonio Avina-Zubieta⁴, Michel Zummer⁵, Milton F. Baker⁶, Jacqueline Stewart⁷, Isabelle Fortin⁸, Michelle Teo⁹, Emmanouil Rampakakis¹⁰, Eliofotisti Psaradellis¹¹, Brendan Osborne¹², Cathy Tkaczyk¹², Karina Maslova¹³, Francois Nantel¹⁴ and Allen J Lehman¹³, ¹University of Saskatchewan, Saskatoon, SK, Canada, ²Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, ³Rheumatology Department, Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁴Medicine, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada, ⁵Rheumatology, Hôpital Maisonneuve-Rosemont and University of Montreal, Montreal, QC, Canada, ⁶VIHA, Victoria, BC, Canada, ⁷Penticton Regional Hospital, Penticton, BC, Canada, ⁸Centre de Rhumatologie de l'Est du Québec, Rimouski, QC, Canada, ⁹Rheumatology, Penticton Regional Hospital, Penticton, BC, Canada, ¹⁰JSS Medical Research, St-Laurent, QC, Canada, ¹¹JSS Medical Research, Montreal, QC, Canada, ¹²Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹³Janssen Inc., Toronto, ON, Canada, ¹⁴19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Dactylitis is one of the most commonly reported features in spondyloarthritis. It has been hypothesized that dactylitis is a functional enthesitis at the proximal…
Abstract Number: 2604 • 2014 ACR/ARHP Annual Meeting
Ankylosing Spondylitis and Non- Radiographic Axial Spondyloarthritis : the Same Syndrome or Different Diseases? Analysis from Esperanza Cohort
Azucena Hernández-Sanz¹, Victoria Navarro-Compán², Cristina Fernández-Carballido³, Carlos Montilla-Morales⁴, Juan Mulero⁵ and Eugenio De Miguel⁶, ¹H. Virgen de la Salud, Toledo, Spain, ²Rheumatology, University Hospital La Paz, Madrid, Spain, ³Rheumatology, University General Hospital Elda, Elda (Alicante), Spain, ⁴H. de Salamanca, Salamanca, Spain, ⁵Rheumatology, University Hospital Puerta de Hierro, Majadahonda (Madrid), Spain, ⁶Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
Background/Purpose New ASAS criteria for axial spondyloarthritis (axSpA) have two entrances: the imaging and clinical arm (presence of HLA B27). The imaging arm allows classifying patients…
Abstract Number: 819 • 2014 ACR/ARHP Annual Meeting
Secukinumab, a Monoclonal Antibody to Interleukin-17A, Significantly Improves Signs and Symptoms of Active Ankylosing Spondylitis: Results of a 52-Week Phase 3 Randomized Placebo-Controlled Trial with Intravenous Loading and Subcutaneous Maintenance Dosing
Dominique L. Baeten¹, Juergen Braun², Xenofon Baraliakos³, Joachim Sieper⁴, Maxime Dougados⁵, Paul Emery⁶, Atul A. Deodhar⁷, Brian Porter⁸, Ruvie Martin⁸, Shephard Mpofu⁹ and Hanno Richards¹⁰, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Charité University Medicine Berlin, Berlin, Germany, ⁵Université Paris René Descartes and Hôpital Cochin, Paris, France, ⁶University of Leeds, Leeds, United Kingdom, ⁷Oregon Health and Sciences University, Portland, OR, ⁸Novartis Pharma AG, East Hanover, NJ, ⁹Novartis Pharma AG, Basel, Switzerland, ¹⁰Clinical Immunology / Dermatology, Novartis Pharma AG, Basel, Switzerland
Background/Purpose A phase 2, proof-of-concept study indicated that secukinumab, an anti–IL-17A monoclonal antibody, suppressed signs and symptoms of active ankylosing spondylitis (AS) by Week (Wk)…
Abstract Number: 604 • 2014 ACR/ARHP Annual Meeting
Characterisation of Mucosal-Associated Invariant T (MAIT) Cells in Ankylosing Spondylitis Patients
Ibrahim Almaghlouth¹, Eric Gracey², Zoya Qaiyum², Robert D. Inman³ and Ammepa Anton⁴, ¹Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Immunology, University of Toronto, Toronto, ON, Canada, ³Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada
Background/Purpose: Ankylosing spondylitis (AS) is chronic inflammatory disease of unknown origin. Studies into the molecular basis of AS have demonstrated exaggerated innate and adaptive immune…
Abstract Number: 600 • 2014 ACR/ARHP Annual Meeting
Differing Patterns of Axial Spondyloarthritis in Females and Males
Ibrahim Almaghlouth^1,2, Arane Thava³, Nigil Haroon⁴ and Robert D. Inman⁵, ¹Internal medicine, University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, Toronto, ON, Canada, ⁴Toronto Western Research Institute, Toronto, ON, Canada, ⁵Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Sex effects have been noted in axial spondyloarthritis (AS) however controversy still exists regarding male and female clinical manifestations of AS. This includes uncertainty…
Abstract Number: 538 • 2014 ACR/ARHP Annual Meeting
Secukinumab, a Monoclonal Antibody to Interleukin-17A, Significantly Improves Physical Function and Quality of Life in Subjects with Active Ankylosing Spondylitis: Results of a Phase 3 Randomized, Placebo-Controlled Trial with Intravenous Loading and Subcutaneous Maintenance Dosing
Atul A. Deodhar¹, Dominique L. Baeten², Jürgen Braun³, Xenofon Baraliakos³, Joachim Sieper⁴, Maxime Dougados⁵, Paul Emery⁶, Brian Porter⁷, Ruvie Martin⁷, Shephard Mpofu⁸ and Hanno Richards⁹, ¹Oregon Health and Sciences University, Portland, OR, ²Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Charité Universitätsmedizin Berlin, Berlin, Germany, ⁵Descartes University, Cochin Hospital, Paris, France, ⁶University of Leeds, Leeds, United Kingdom, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Clinical Immunology / Dermatology, Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Ankylosing spondylitis (AS) can have a profound negative effect on an individual's physical functioning, health status and quality of life (QoL), affecting the ability…

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