Abstracts tagged "Arthritis and major histocompatibility complex (MHC)"

Abstract Number: 983 • ACR/ARHP Annual Meeting 2015
ERAP1 Deficiency Protects HLA-B27 Transgenic Rats from Arthritis
Tri M. Tran¹, Sohee Hong², Tejpal Gill¹, Joshua Bennett¹, Keith Sikora¹ and Robert A. Colbert³, ¹NIAMS/NIH, Bethesda, MD, ²Bldg 10 Crc 10 Center Dr, NIAMS/NIH, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: HLA-B27 (B27) confers a strong predisposition to spondyloarthritis (SpA), but accounts for < 25% of overall heritability of ankylosing spondylitis. Rats transgenic for HLA-B27…