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Abstracts tagged "arthritis and bone remodeling"

  • Abstract Number: 1444 • ACR/ARHP Annual Meeting 2016

    Differential Expression of Wnt Inhibitors before and after Joint Inflammation Onset in Rat Arthritis Could Partly Explain Paradoxical Effect of Sclerostin Inhibition

    Guillaume Courbon1, Raphaelle Lamarque2, Marie-Thérèse Linossier2, Norbert Laroche2, Thierry Thomas3, Laurence Vico2 and Hubert Marotte3, 1SAINBIOSE INSERM U1059, University of Lyon, Saint-Etienne, France, 2SAINBIOSE INSERM U1059, University of Lyon, Saint Etienne, France, 3SAINBIOSE INSERM U1059 and Rheumatology department, University of Lyon and University Hospital of Saint Etienne, Saint Etienne, France

    Background/Purpose:  Periarticular bone loss in rheumatoid arthritis is considered to be mainly related to synovial inflammation, leading to uncoupling between decreased bone formation and increased…

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