Abstracts tagged "arthritis and autoimmune diseases"

Abstract Number: 1813 • ACR/ARHP Annual Meeting 2014
DNA Sensors Regulate Inflammation in a Model of Autoimmune Arthritis
Rebecca Baum¹, Shruti Sharma², Sudesh Pawaria³, Susan Carpenter⁴, Katherine A. Fitzgerald⁵, Ann Marshak-Rothstein⁶ and Ellen M. Gravallese⁷, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine - Infectious Diseases Division, University of Massachusetts Medical School, Worcester, MA, ³Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ⁴University of California, San Francisco, San Francisco, CA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁷Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Innate immune sensors such as cytosolic DNA sensors and toll-like receptors (TLRs) detect viral or bacterial DNA, resulting in production of proinflammatory cytokines and…