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Abstracts tagged "APRIL"

  • Abstract Number: 2797 • 2013 ACR/ARHP Annual Meeting

    B-Lymphocyte Stimulator and A Proliferation Inducing Ligand In Lupus Nephritis: Low Serum Levels Of BLyS Predict Treatment Response

    Ioannis Parodis1, Agneta Zickert1, Elisabet Svenungsson2, Vivianne Malmström2 and Iva Gunnarsson1, 1Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: B-lymphocytes have a pivotal role in the pathogenesis of Systemic Lupus Erythematosus (SLE). B-Lymphocyte Stimulator (BLyS) has an important role in the activation, differentiation…
  • Abstract Number: 2551 • 2013 ACR/ARHP Annual Meeting

    Pharmacodynamics and Predictive Biomarkers In Patients Treated With Atacicept: Data From The APRIL-SLE Trial

    David A. Isenberg1, David Wofsy2, Yong Li3, Daiana Licu4, Stephen D. Wax5, Caroline Gordon6 and Claudia Pena Rossi4, 1Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 2Rheumatology/Immunology, University of California San Francisco and NIAID Autoimmunity Centers of Excellence, San Francisco, CA, 3EMD Serono, Rockland, MA, 4Merck Serono S.A., Geneva, Switzerland, 5Global Clinical Development Center - Immunology, EMD Serono Inc, Rockland, MA, 6Rheumatology Research Group (East Wing), School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Atacicept is a fusion protein that inhibits B cell stimulating factors BLyS and APRIL. We examined the pharmacodynamic (PD) effects of atacicept in patients…
  • Abstract Number: 1759 • 2012 ACR/ARHP Annual Meeting

    Expression of Surface APRIL and Its Receptor, TACI, Is Upregulated On B Cells From Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

    Abby Jones Weldon1, Sheri Hsu2, Seyed K. Nazeri3, Saru Sachdeva2, Jennifer Gonzalez4, Andrea D. Parra5, Abigail Benitez1, Keith K. Colburn6, Ioana Moldovan7 and Kimberly J. Payne8, 1Microbiology and Molecular Genetics, Loma Linda University, Loma Linda, CA, 2Rheumatology, Loma Linda University Medical Center, Loma Linda, CA, 3Rheumatology, Loma Lida University Medical Center, Loma Lida, CA, 4Center of Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, CA, 5Center for Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, CA, 6Dept Med - Rheum Sect, Loma Linda Univ Medical Center, Loma Linda, CA, 7Loma Linda Univ Medical Center, Loma Linda, CA, 8Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA

    Background/Purpose: Autoimmune disease affects more than 23 million Americans. Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) are chronic, systemic B-cell mediated autoimmune diseases. During…
  • Abstract Number: 1756 • 2012 ACR/ARHP Annual Meeting

    Peripheral Blood B Cell Subsets and BAFF/APRIL Receptor Expression, Together with Circulating BAFF and APRIL Levels, Are Disturbed in Rheumatoid Arthritis but Not in Ankylosing Spondylitis

    Béatrice Gaugler1, Caroline Laheurte2, Ewa Bertolini3, Daniel Wendling4, Philippe Saas5, Eric Toussirot6 and CIC BT5067, 1EFS Bourgogne Franche Comté, INSERM UMR1098 / Etablissement Français du Sang / Université de Franche Comté, Besançon, France, 2Etablissement Français du Sang/ Université de Franche Comté / CBT506 / CHRU, INSERM UMR1098 / Plateforme Biomonitoring, Besançon, France, 3University Hospital, Rheumatology, Besançon, France, 4Service de Rhumatologie, Minjoz University Hospital, Besancon, France, 5Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France, 6Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, 7Chru, Clinical Investigation Center Biotherapy, Besançon, France

    Background/Purpose: B cells play a critical role in systemic autoimmune disease and especially rheumatoid arthritis (RA). BAFF and APRIL are involved in B cell activation…
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