Abstracts tagged "apoptotic clearance"

Abstract Number: 2087 • 2018 ACR/ARHP Annual Meeting
Kidney Tissue Damage in Mice with Single and Combined Abnormalities in Complement, Interferon and Apoptotic Cell Clearance
Sladjana Skopelja-Gardner¹, YuFeng Peng², Payton Hermanson², Lucrezia Colonna², Xizhang Sun³, Lena Tanaka⁴, Anne Davidson⁵, David Salant⁶ and Keith B. Elkon⁷, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA, ⁴Medicine/Rheumatology, University of Washington, Seattle, WA, ⁵Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Boston University, Boston, MA, ⁷University of Washington, Seattle, WA
Background/Purpose: Lupus nephritis (LN) affects ~70% of systemic lupus erythematosus (SLE) patients and is one of the main contributors to morbidity and mortality. While defective…
Abstract Number: 1111 • 2015 ACR/ARHP Annual Meeting
Relapse of Lupus after B-Cell Depletion Therapy Is Associated with Loss of Apoptotic Cell Clearance and Elevated Type I Interferon Responses in Lupus Prone BXD2
Hui-Chen Hsu^1,2, Zhaoqi Yan³, PingAr Yang², Qi Wu^1,2, Jennie Hamilton⁴, Jun Li⁵, Hao Li⁶, Bao Luo⁶, Laurie Harrington³ and John Mountz⁷, ¹Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Cell, Developmntl & Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Dept of Med/Rheumatology Div, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL
Background/Purpose: B-cell depletion therapy (BCDT) is a promising therapy for autoimmune diseases but relapse can occur. In rheumatoid arthritis, patients who did not respond well…
Abstract Number: 3214 • 2015 ACR/ARHP Annual Meeting
Impaired Phagocytosis of Apoptotic Cells in Pristane-Induced Lupus Simulates the Clearance Defect in Human SLE
Shuhong Han¹, Haoyang Zuang¹, Ravil Khaybullin², Stepan Shumyak³, Anan Afaneh⁴, Xin Qi⁵, Lijun yang⁶ and Westley H. Reeves⁷, ¹Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL, ²medicinal chemistry, University of Flordia, gainesville, FL, ³division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁴Division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁵medicinal chemistry, University of Florida, gainesville, FL, ⁶Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, ⁷Medicine, University of Florida, Gainesville, FL
Background/Purpose: Defective phagocytosis of dead cells is seen in SLE patients’ monocytes. Pristane-induced lupus causes accumulation of dead cells in tissues resembling that in SLE…
Abstract Number: 2844 • 2014 ACR/ARHP Annual Meeting
Intracellular Complement C3 Is Exposed on the Cell Surface upon Apoptosis Induction and Participates in the Clearance of Apoptotic Cells By Phagocytes
Lucrezia Colonna¹, Christian Lood¹, YuFeng Peng², Xizhang Sun³, Lena Tanaka³, Sandip Panicker⁴ and Keith B. Elkon³, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴True North Therapeutics, South San Francisco, CA
Background/Purpose The complement system has been viewed as a predominantly serum-derived host defense mechanism with multiple functions, including clearance of apoptotic cells. Defective function of…
Abstract Number: 657 • 2014 ACR/ARHP Annual Meeting
Distinct Contributions of C1q and C3 in Preventing Immunogenicity of Apoptotic Cells in Lupus
Clayton Sontheimer¹, Yenly Nguyen², Keith B. Elkon³ and YuFeng Peng³, ¹Pediatric Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Defective clearance of apoptotic cells (AC) and complement deficiency are important contributors to the pathogenesis of systemic lupus. Dead (sunburn) cells and complement…
Abstract Number: 1618 • 2013 ACR/ARHP Annual Meeting
Chromatin Binding In SLE Patients Correlates With The Intensity Of Apoptotic Binding By 9G4+ B Cells
Asiya Seema Chida¹, Quan-Zhen Li², Chandra Mohan³, Youliang Wang¹, Scott Jenks⁴, Louise Hartson¹ and Ignacio Sanz⁵, ¹Medicine, Emory University Medical Center, Atlanta, GA, ²Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, ³University of Houston, Houston, TX, ⁴Allergy, Immunology, and Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁵Rheumatology, Emory University, Atlanta, GA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multi-organ autoimmune disease characterised by production of autoantibodies to multiple nuclear antigens, some of which are highly specific…
Abstract Number: 1170 • 2013 ACR/ARHP Annual Meeting
Expression and Function Of Human Mfg-E8 In The Clearance Of Apoptotic Cells and Suppression Of Inflammation
Lucrezia Colonna¹, Jie An², Xizhang Sun³, Nalini Agrawal⁴, Alice Wiedeman⁵ and Keith B. Elkon³, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴Rheumatology, University of Washington, Seattle, WA, ⁵Immunology, University of Washington, Seattle, WA
Background/Purpose: Effective clearance of apoptotic cells (AC) is necessary for the maintenance of tolerance to self. MFG-E8 is one of ~20 different opsonins reported to…

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