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Abstracts tagged "antiphospholipid syndrome"

  • Abstract Number: 1467 • ACR Convergence 2023

    Antiphospholipid Antibodies and the Risk of Diffuse Alveolar Hemorrhage in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

    Mariana Gonzalez-Trevino1, Jeffrey Yang2, Larry J. Prokop3, Gabriel Figueroa-Parra1 and Ali Duarte-Garcia4, 1Division of Rheumatology, Mayo Clinic, Rochester, MN, 2Department of Internal Medicine, Mayo Clinic, Rochester, MN, 3Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, 4Mayo Clinic, Rochester, MN

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is one of the most devastating complications of SLE. The exact pathogenesis leading to DAH in SLE is not well…
  • Abstract Number: 0106 • ACR Convergence 2023

    Positive Antiphospholipid Antibodies Are Associated with a Higher Risk of Cerebral Microbleeds

    Junna Ye1, Yijun You2, Zhuochao Zhou2, Fan wang2, Jingyi Wu2 and Chengde Yang2, 1Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China, 2Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Background/Purpose: Persistent presence of antiphospholipid antibodies (aPLs) are important thrombosis-related laboratory parameters, as well as an indication of anticoagulation use which usually cause higher bleeding…
  • Abstract Number: 1603 • ACR Convergence 2023

    Infection-Associated Antiphospholipid Antibodies and Their Potential Role in Sepsis Outcomes

    Katarina Kmetova, Emily Chong, NaveenKumar K. Somanathapura, Sherwin Navaz, Lyndsay Kluge, Srilakshmi Yalavarthi, Jason Knight, Michael Maile and Yu Zuo, University of Michigan, Ann Arbor, MI

    Background/Purpose: Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia characterized by circulating antiphospholipid antibodies (aPL). While the association between aPL and infection has long been…
  • Abstract Number: 0107 • ACR Convergence 2023

    Impact of Antiphospholipid Syndrome on Mortality of Hospitalized Ischemic Stroke Patients: A Retrospective Analysis of the National Inpatient Sample Database 2020

    Sami Rabah, Lincoln Medical Center, New York, NY

    Background/Purpose: Antiphospholipid syndrome (APS) is recognized for its association with an elevated risk of ischemic strokes and other thromboembolic events. This study aims to compare…
  • Abstract Number: 1604 • ACR Convergence 2023

    First and Recurrent Thrombosis Risk After 4,454 Patient-Years of Follow-Up: Prospective Results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)

    Jonathan Thaler1, Yasaman Ahmadzadeh2, Danieli Andrade3, leslie skeith4, Maria Tektonidou5, Savino Sciascia6, Vittorio Pengo7, Jose Pardos-Gea8, Guillermo Ruiz-Irastorza9, Chary Lopez-Pedrera10, H Michael Belmont11, Kello Nina12, Paul R. Fortin13, Denis WAHL14, Maria Gerosa15, Guilherme De Jesús16, Zhuoli Zhang17, Tatsuya Atsuma18, Maria Efthymiou19, D. Ware Branch20, Laura Andreoli21, Esther Rodriguez almaraz22, Michelle Petri23, Giulia Pazzola24, Ricard Cervera25, Bahar Artim Esen26, Hui Shi27, Jason Knight27, Guillermo Pons-Estel28, Rohan Willis29, Ali Duarte-Garcia30, Maria Laura Bertolaccini31, Hannah Cohen32, Doruk Erkan1 and On Behalf Of APS ACTION33, 1Hospital for Special Surgery, New York, NY, 2Roger Williams Medical Center, Providence, RI, 3University of São Paulo, São Paulo, Brazil, 4University of Calgary, Calgary, AB, Canada, 5Joint Academic Rheumatology Program, First Department of Propedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, 6University of Turin, Torino, Italy, 7Department of Cardiac-Thoracic-Vascular Sciences and Public Health University of Padova, Padova, Italy, 8Vall d'Hebron University Hospital, Barcelona, Spain, 9Hospital Universitario Cruces, Barakaldo, Spain, 10IMIBIC - Reina Sofia Hospital, Córdoba, Spain, 11NYU School of Medicine, New York, NY, 12Northwell Health, Brooklyn, NY, 13Centre ARThrite - CHU de Québec - Université Laval, Quebec City, QC, Canada, 14University of Lorraine, Nancy, France, 15University of Milan, Milano, Italy, 16Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Brazil, 17Peking University First Hospital, Rheumatology and Immunology Department, Beijing, China, 18Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Sapporo, Japan, 19University College London, London, United Kingdom, 20University of Utah, Salt Lake City, UT, 21University of Brescia, Brescia, Italy, 22Hospital Universitario 12 de Octubre, Madrid, Spain, 23Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 24Azienda Ospedaliera Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Italy, 25Hospital Clínic de Barcelona, Barcelona, Spain, 26Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 27University of Michigan, Ann Arbor, MI, 28CREAR, Rosario, Argentina, 29University of Texas Medical Branch, Galveston, TX, 30Mayo Clinic, Rochester, MN, 31King's College London, London, United Kingdom, 32University College London Hospitals NHS Foundation Trust, London, United Kingdom, 33on behalf of APS ACTION, New York, NY

    Background/Purpose: The APS ACTION Registry was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients with or…
  • Abstract Number: 0108 • ACR Convergence 2023

    Decoding Antiphospholipid Syndrome Laboratory Test Outcomes in a Large Multicenter Electronic Health Record Database

    Emily Balczewski, Wenying Liang, Amala Ambati, Yu Zuo, Karandeep Singh and Jason Knight, University of Michigan, Ann Arbor, MI

    Background/Purpose: Electronic health record (EHR) data provide an inexpensive, information-rich tool to study rare diseases like antiphospholipid syndrome (APS). Many such studies rely on structured…
  • Abstract Number: 1605 • ACR Convergence 2023

    Complement Activation as a Marker of Thrombosis Risk in Antiphospholipid Antibody Positive Patients: Prospective Results from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)

    Cecile Yelnik1, Shruti Chaturvedi2, Julien Labreuche1, Xiang-Zuo Pan3, H Michael Belmont4, Kello Nina5, Paul R. Fortin6, D. Ware Branch7, Yu Zuo8, Rohan Willis9, Robert Brodsky10, Jane Salmon11, Maria Laura Bertolaccini12, Hannah Cohen13, Michelle Petri14, Doruk Erkan11 and On Behalf Of APS ACTION15, 1University of Lille, Lille, France, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3John Hopkins University, Baltimore, MD, 4NYU School of Medicine, New York, NY, 5Northwell Health, Brooklyn, NY, 6Centre ARThrite - CHU de Québec - Université Laval, Quebec City, QC, Canada, 7University of Utah, Salt Lake City, UT, 8University of Michigan, Ann Arbor, MI, 9University of Texas Medical Branch, Galveston, TX, 10Johns Hopkins University, Baltimore, MD, 11Hospital for Special Surgery, New York, NY, 12King's College London, London, United Kingdom, 13University College London Hospitals NHS Foundation Trust, London, United Kingdom, 14Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 15on behalf of APS ACTION, New York, NY

    Background/Purpose: Recent studies implicate complement activation in the pathophysiology of antiphospholipid syndrome (APS), especially in patients with severe manifestations, such as catastrophic APS (CAPS). This…
  • Abstract Number: 0109 • ACR Convergence 2023

    Persistent Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome

    Bruna Mazetto, NaveenKumar Somanathapura, Claire Hoy, Christine Rysenga, Srilakshmi Yalavarthi, Cyrus Sarosh, Caroline Ranger, Katarina Kmetova, Jacqueline Madison, Yu Zuo and Jason Knight, University of Michigan, Ann Arbor, MI

    Background/Purpose: Inappropriately amplified inflammatory responses are hallmarks of many diseases, with extracellular ATP often playing a central role in the orchestration of inflammation. Regulated cellular…
  • Abstract Number: 1606 • ACR Convergence 2023

    Purinergic Signaling as a Potential Therapeutic Target for APS Thromboinflammation

    NaveenKumar K. Somanathapura, Claire Hoy, Srilakshmi Yalavarthi, Cyrus Sarosh, Bruna De Moraes Mazetto Fonseca, Caroline Ranger, Christine Rysenga, Ajay Tambralli, Jacqueline Madison, Yu Zuo and Jason Knight, University of Michigan, Ann Arbor, MI

    Background/Purpose: In first responding cells such as neutrophils and platelets, extracellular ATP released from activated or dying cells engages cell-surface receptors to launch proinflammatory and…
  • Abstract Number: 0110 • ACR Convergence 2023

    Neutrophil Extracellular Traps as Mediators of Antiphospholipid Antibody-Induced Trophoblast Dysfunction and Fetal Loss

    Christine Rysenga, Srilakshmi Yalavarthi, Wenying Liang, Claire Hoy, Cyrus Sarosh, Richard Lieberman, Yu Zuo and Jason Knight, University of Michigan, Ann Arbor, MI

    Background/Purpose: Antiphospholipid antibodies (aPL) induce obstetric complications associated with placental insufficiency by promoting trophoblast dysfunction and inflammation at the maternal-fetal interface. Neutrophils have been found…
  • Abstract Number: 1607 • ACR Convergence 2023

    Autoantibodies to Transcription Factor a Mitochondria Link Mitochondrial Damage and Thrombosis in Systemic Lupus Erythematosus

    Eduardo Gomez-Banuelos1, Alessandra Ida Celia2, Maria Isabel Trejo Zambrano3, Merlin Paz3, Erika Darrah3, Daniel Goldman4, Michelle Petri4 and Felipe Andrade3, 1The Johns Hopkins University, Baltimore, MD, 2John Hopkins University of Medicine, Rome, Italy, 3Johns Hopkins University, Baltimore, MD, 4Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Upon activation with interferon (IFN) and RNP-immune complexes, defective mitophagy in neutrophils results in the release of mtDNA in complex with transcription factor A…
  • Abstract Number: 0111 • ACR Convergence 2023

    Hippo-YAP1-CCN2 Signaling by Microvascular Endothelial Cells Licenses Vascular Smooth Muscle Cell Proliferation in Antiphospholipid Syndrome

    Wenying Liang1, Allison Billi1, Srilakshmi Yalavarthi1, Christine Rysenga1, Claire Hoy1, Cyrus Sarosh1, Yu Zuo1, Eliza Pei-Suen Tsou1, Jason Knight1 and Hui Shi2, 1University of Michigan, Ann Arbor, MI, 2Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Background/Purpose: Some patients with antiphospholipid syndrome (APS) are afflicted by an insidious small-vessel vasculopathy that results in the accrual of organ damage over time. While…
  • Abstract Number: 1608 • ACR Convergence 2023

    Plasma Proteomic Profiling in Antiphospholipid Antibody-positive Patients with Different Clinical Phenotypes: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry

    Ayesha Butt1, Rolando Garcia Milian1, George Goshua1, Sean Gu1, Eugenia Chock2, Valentina Restrepo1, John Hwa1, Hyung Chun1, H Michael Belmont3, Kello Nina4, D. Ware Branch5, Michelle Petri6, Jason Knight7, Rohan Willis8, Maria Laura Bertolaccini9, Doruk Erkan10, Alfred lee1, Anish Sharda1 and Alexander Pine11, 1Yale School of Medicine, New Haven, CT, 2Yale School of Medicine, Greenwich, CT, 3NYU School of Medicine, New York, NY, 4Northwell Health, Brooklyn, NY, 5University of Utah, Salt Lake City, UT, 6Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 7University of Michigan, Ann Arbor, MI, 8University of Texas Medical Branch, Galveston, TX, 9King's College London, London, United Kingdom, 10Hospital for Special Surgery, New York, NY, 11VA Connecticut/Yale School of Medicine, West Haven, CT

    Background/Purpose: Antiphospholipid syndrome (APS) is an autoimmune disease with thrombotic and obstetric complications arising via a model of immunothrombosis. Patients may present with a spectrum…
  • Abstract Number: 0096 • ACR Convergence 2023

    Performance Assessment of Lupus Anticoagulant Tests Using Taipan and Ecarin Snake Venom Clotting Times: An International Study from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Core Laboratories

    Maria Efthymiou1, Ian Mackie1, Rohan Willis2, Vittorio Pengo3, Danieli Andrade4, Elisa Bison3, Olga Amengual5, Zurina Romay-Penabad6, Yuichiro Fujieda5, Maria Laura Bertolaccini7, Doruk Erkan8, Hannah Cohen9 and On Behalf Of APS ACTION10, 1University College London, London, United Kingdom, 2University of Texas Medical Branch, Galveston, TX, 3Department of Cardiac-Thoracic-Vascular Sciences and Public Health University of Padova, Padova, Italy, 4University of São Paulo, São Paulo, Brazil, 5Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan, 6Antiphospholipid Standardization Laboratory, Division of Rheumatology, University of Texas Medical Branch, TX, 7King's College London, London, United Kingdom, 8Hospital for Special Surgery, New York, NY, 9University College London Hospitals NHS Foundation Trust, London, United Kingdom, 10on behalf of APS ACTION, New York, NY

    Background/Purpose: Lupus anticoagulant (LA) test performance is critical for APS diagnosis and management. However, variability remains a challenge in LA testing, particularly in anticoagulated samples,…
  • Abstract Number: 0112 • ACR Convergence 2023

    Molecular Stratification of Antiphospholipid Syndrome Patients Through Integrative Analysis of the Whole-blood RNA Transcriptome

    Amala Ambati1, Feiyang Ma1, Katarina Kmetova1, Sherwin Navaz1, Claire Hoy1, Cyrus Sarosh1, Ajay Tambralli1, Johann E. Gudjonsson1, J. Michelle Kahlenberg1, Jacqueline Madison1, Ali Duarte-Garcia2, Jason Knight1 and Yu Zuo1, 1University of Michigan, Ann Arbor, MI, 2Mayo Clinic, Rochester, MN

    Background/Purpose: Antiphospholipid syndrome (APS) is an acquired thrombo-inflammatory disease associated with diverse clinical manifestations in the setting of persistent antiphospholipid antibodies (aPL). Early diagnosis and…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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