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Abstracts tagged "antiphospholipid syndrome"

  • Abstract Number: 2090 • 2016 ACR/ARHP Annual Meeting

    Investigating the Genetic Variations of Antiphospholipid Syndrome By High-Throughput Exome Sequencing

    Sung-Hoon Park1, Chan Uk Lee1, Ji Na Kim2, Ji-Won Kim1, Hwajeong Lee2, Seong-Kyu Kim2 and Jung-Yoon Choe1, 1Medicine, Catholic university of Daegu School of medicine, Daegu, Korea, The Republic of, 2Catholic university of Daegu School of medicine, Daegu, Korea, The Republic of

    Background/Purpose:  The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies in serum together with clinical manifestations such as thrombosis,…
  • Abstract Number: 2092 • 2016 ACR/ARHP Annual Meeting

    Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 Is Elevated in Patients with Thrombotic Primary Antiphospholipid Syndrome.  

    Yair Molad1,2, Yonatan Edel3,4, Yael Pri-Paz Basson5, Elisheva Pokroy-Shapira6, Shirly Oren5, Ariela Dortort5 and Vitaly Kliminski4,7, 1Rheumatology Unit, Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel, 2Laboratory of Inflammation Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, 3Department of Medicine C, Beilinson Hospital, Rabib Medical Center, Petach Tikva, Israel, 4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 5Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel, 6Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel, 7Laboratory of Inflammation Research, Felsenstein Medical Research Center, Rabin Medical Center, Petach Tikva, Israel

    Background/Purpose : Primary antiphospholipid syndrome (PAPS) is characterized by thrombotic and/or obstetrical morbidity in the presence of persistent antiphospholipid antibodies (APLA) and in the absence…
  • Abstract Number: 2094 • 2016 ACR/ARHP Annual Meeting

    Complement Activation in Antiphospholipid Syndrome Due to the Multi-Activated Pathways of the Complement System

    Hiroyuki Nakamura1, Kenji Oku2, Ryo Hisada2, Kazumasa Ohmura2, Masaru Kato2, Toshiyuki Bohgaki2, Olga Amengual2, Tetsuya Horita2, Shinsuke Yasuda2 and Tatsuya Atsumi2, 1Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Background/Purpose:  Complement activation is proposed as one of the major thrombophilic mechanisms in antiphospholipid syndrome (APS). Among three complement pathways (classical, alternative and lectin), activation…
  • Abstract Number: 2095 • 2016 ACR/ARHP Annual Meeting

    Autoantibodies Against High Density Lipoprotein-Associated Proteins Are Related to Elevated Oxidized Low Density Lipoprotein Levels in Antiphospholipid Syndrome

    Kenji Oku1, Uhei Shibata2, Joana Batuca3, Olga Amengual4, Michihiro Kono2, Hiroyuki Nakamura5, Ryo Hisada1, Kazumasa Ohmura1, Masaru Kato2, Toshiyuki Bohgaki1, Shinsuke Yasuda1, Jose Delgado Alves3,6 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3CEDOC/NOVA Medical School, Lisbon, Portugal, 4Hokkaido University,Medicine II, Sapporo, Japan, 5Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 6Fernando Fonseca Hospital, Amadora, Portugal

    Background/Purpose: Oxidized low-density lipoprotein (oxLDL), a key molecule in atherogenesis, serves as the source of anionic charged particles that bind to beta2glycoprotein I (Β2GPI) and…
  • Abstract Number: 77 • 2016 ACR/ARHP Annual Meeting

    Integrated Analysis of Microrna and mRNA Expression Profiles Related to Cardiovascular Disease in Monocytes from Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome Patients

    Carlos Perez-Sanchez1, Maria Ángeles Aguirre Zamorano1, Patricia Ruiz-Limon2, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Maria Carmen Abalos-Aguilera2, Ivan Arias de la Rosa2, María Galindo3, Eduardo Collantes-Estévez1, Maria Jose Cuadrado4 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, 4St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: The interplay between miRNAs and their mRNA targets might constitute an important mechanism in the regulation of the proatherothrombotic status of SLE and APS…
  • Abstract Number: 2099 • 2016 ACR/ARHP Annual Meeting

    Micrornas As Potential Modulators of Atherothrombosis in Antiphospholipid Syndrome

    Patricia Ruiz-Limon1, Maria Ángeles Aguirre Zamorano2, Nuria Barbarroja2, Yolanda Jiménez-Gómez2, IVÁN ARIAS DE LA ROSA2, Eduardo Collantes-Estévez2, Pedro Segui2, Francisco Velasco3, Rocio Gonzalez-Conejero4, Raul Teruel4, Constantino Martinez4, Maria Jose Cuadrado5, Carlos Perez-Sanchez2 and Chary Lopez-Pedrera2, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Hematology, IMIBIC-Reina Sofia Hospital, Hematology Unit, Cordoba, Spain, 4Regional Centre for Blood Donation, University of Murcia, Murcia, Spain, 5St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: 1) To identify and characterize microRNAs linked to thrombosis and atherosclerosis development in APS; 2) To assess the effects of antiphospholipid antibodies in that…
  • Abstract Number: 920 • 2016 ACR/ARHP Annual Meeting

    Autoantigen-Specific T Cell and Antibody Reactivity to a Human Gut Commensal in Antiphospholipid Syndrome

    William Ruff1, Carina Dehner2, Alex Roth1, Silvio M. Vieira1, Cassyanne L. Aguiar3,4, Andrew Goodman5, Doruk Erkan6 and Martin Kriegel1, 1Immunobiology, Yale School of Medicine, New Haven, CT, 2Immunobiology, Yale School of Medicine, new haven, CT, 3Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 4Cohen Children's Medical Center of New York/ Hofstra Northwell School of Medicine, Pediatric Rheumatology, New York, NY, 5Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, 6Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY

    Autoantigen-specific T Cell and Antibody Reactivity to a Human Gut Commensal in Antiphospholipid Syndrome William Ruff1, Carina Dehner1, Alex Roth1, Silvio M. Vieira1, Cassyanne L.…
  • Abstract Number: 2875 • 2016 ACR/ARHP Annual Meeting

    Depressed Serum IgM Levels in SLE Are Restricted to Defined Subgroups

    Caroline Grönwall1, Uta Hardt1, Iva Gunnarsson2, Gregg J. Silverman3 and Elisabet Svenungsson1, 1Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Department of Medicine, Unit of Rheumatology, Stockholm, Sweden, 3Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Natural IgM autoantibodies have been proposed to have protective properties, and decreased levels of IgM to phosphorylcholine (PC) in SLE are associated with higher…
  • Abstract Number: 2174 • 2015 ACR/ARHP Annual Meeting

    Neutrophils in Primary Antiphospholipid Syndrome Are Characterized By a Prominent Activated Phenotype and Uniquely Remodeled Chromatin Architecture

    Patrick Coit, Srilakshmi Yalavarthi, Jason S. Knight and Amr H. Sawalha, Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent thrombotic events, pregnancy complications, and the presence of antiphospholipid antibodies. The pathogenesis of…
  • Abstract Number: 2175 • 2015 ACR/ARHP Annual Meeting

    Comparative Study Between Coagucheck XS Versus Standard Laboratory Practice Protrombine Time for Monitoring Anticoagulant Therapy in Patients with Antiphospholipid Syndrome   

    Maria Ester Simeira Fonseca1, Michelle Lopes2, Christiane Pereira Gouvea3 and Danieli Andrade4, 1Rheumatology, University of São Paulo, São Paulo, Brazil, 2Rheumatology, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, 3Hematology, University of São Paulo, São Paulo, Brazil, 4Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY

    Background/Purpose:  Antiphospholipid Syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. Although initially described in patients with systemic lupus erythematosus (SLE) it…
  • Abstract Number: 2178 • 2015 ACR/ARHP Annual Meeting

    Oxidation of beta2-Glycoprotein I (beta2-GPI) Associates with the Presence of Antibodies to Domain I of beta2-GPI in Patients with the Antiphospholipid Syndrome but Is Not Affected By the Antibodies in Vivo in a Rat Model

    Maria Gabriella Raimondo1,2, Charis Pericleous3, Anna Radziszewska4,5, Maria Orietta Borghi6,7, Silvia S. Pierangeli8, Pier Luigi Meroni6,9, Ian Giles3, Anisur Rahman3 and Yiannis Ioannou3,10, 1Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 2Centre for Rheumatology Research, UCL Division of Medicine, University College London, London, United Kingdom, 3Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 4The Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, 5The Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 6Department of Clinical Sciences and Community Health, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 7Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Milan, Italy, 8Rheumatology/Internal Medicine, University of Texas Medical Branch, Galveston, TX, 9Immunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Cusano Milanino (mi), Italy, 10Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology, UCL Division of Medicine, London, United Kingdom

    Background/Purpose:  β2GPI represents the major antigenic target for antiphospholipid antibodies (aPL), the hallmark of antiphospholipid syndrome (APS). β2GPI contains five homologous domains, with domain I…
  • Abstract Number: 2180 • 2015 ACR/ARHP Annual Meeting

    Primary Antiphospholipid Syndrome Patients Display Increased Levels of Cell-Bound C4d in Comparison to SLE and Healthy Donors

    Maria Gerosa1,2, Paola Adele Lonati3, Tania Ubiali1, Martina Cornalba1, Maria Orietta Borghi1,4 and Pier Luigi Meroni1,2,5, 1Department of Clinical Sciences and Community Health, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 2Division of Rheumatology, Division of Rheumatology, Istituto Ortopedico Gaetano Pini, Milan, Italy, 3Laboratory of Immuno-rheumatology, Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Jamaica, 4Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Milan, Italy, 5Laboratory of Immuno-rheumatology, Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Italy

    Background/Purpose: Systemic Lupus Erythematosus (SLE) patients display high levels of the cell-bound complement activation factor C4d deposits on erythrocytes, B lymphocytes and platelets. In particular,…
  • Abstract Number: 2183 • 2015 ACR/ARHP Annual Meeting

    Clinical and Epidemiological Correlates of the Adjusted Global Anti-Phospholipid Syndrome Score in a Large Cohort of Chinese APS Patients

    Yu Zuo1, Chun Li2, David R. Karp3 and Zhanguo Li2, 1Rheumatology, UT Southwestern Medical Center, Dallas, TX, 2Peking University People's Hospital, Beijing, China, 3UT Southwestern Medical Center, Dallas, TX

    Background/Purpose: It is well known that anti-phospholipid antibodies (aPL) are associated with an increased risk of arterial and venous thrombosis and pregnancy loss/morbidity. However, anticoagulation…
  • Abstract Number: 2184 • 2015 ACR/ARHP Annual Meeting

    Non-Criteria Clinical Manifestations in Antiphospholipid Syndrome: Clinical Behavior and Association with Damage Accrual

    Gabriela Hernandez-Molina1, Cindy Maldonado-Garcia1 and Antonio R. Cabral2, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 2Immunology & Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico

    Background/Purpose: The relevance of non-criteria clinical manifestations of antiphospholipid syndrome (APS) has been less studied than its thrombotic and obstetric features. The aim of this…
  • Abstract Number: 2186 • 2015 ACR/ARHP Annual Meeting

    The Role of Hydroxychloroquine Treatment on Pregnancy Outcome in Women with Antiphospholipid Antibodies

    Savino Sciascia1, Beverely J Hunt2, Eva Talavera-Garcia3, Gloria Lliso3, Munther Khamashta3 and Mª Jose Cuadrado4, 1Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, 2Thrombosis & Haemostasis, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, London, United Kingdom, 3Louise Coote Lupus Unit, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, London, United Kingdom, 4Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom

    Background/Purpose: With good management, around 70% of pregnant women with Antiphospholipid Syndrome (APS) will deliver a viable live infant.However, current management does not prevent all…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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