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Abstracts tagged "antiphospholipid syndrome"

  • Abstract Number: 2762 • 2017 ACR/ARHP Annual Meeting

    Study of 60 Patients with Intrauterine Fetal Deaths Related to Antiphospholipid Syndrome

    Mériem Belhocine1, Laetitia Coutte2, Nicolas Martin Silva3, Nathalie Morel4, Gaelle Guettrot-Imbert4, Romain Paule4, Michel Dreyfus5, Micaela Fredi6, Odile Souchaud-Debouverie7, Jean Charles Piette8, Veronique Le Guern4 and Nathalie Costedoat-Chalumeau1, 1Service de médecine interne Pôle médecine, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares de l’île de France, Paris, France, 2Department of Internal Medicine, Department of Internal Medicine, Cochin University Hospital, paris, France, 3Department of Internal Medicine, Department of Internal Medicine, University Hospital Center of Caen, Caen, France, 4Department of Internal Medicine, Department of Internal Medicine, Cochin University Hospital, Paris, France, 5Department of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, University Hospital Center of Caen, Caen, France, 6Department of Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, 7Department of Internal Medicine, Department of Internal Medicine, Poitiers University Hospital, Poitiers, France, 8Department of Internal Medicine, Department of Internal Medicine, University Hospital Pitié-Salpétrière, Paris, France

    Background/Purpose: The antiphospholipid syndrome (APS) is defined by a combination of arterial and/or venous thrombosis, pregnancy morbidity, and persistent antiphospholipid antibodies. There is a real…
  • Abstract Number: 1 • 2017 ACR/ARHP Annual Meeting

    Anti-Phosphatidylserine/Prothrombin Antibodies (aPS/PT) As Potential Diagnostic Markers and Risk Predictors of Venous Thrombosis and Obstetric Complications in Antiphospholipid Syndrome

    Hui Shi1, Qiongyi Hu2, Hui Zheng2, Jialin Teng2, Gary Norman3, Jinfeng Zhou4 and Chengde Yang2, 1Department of Rheumatology and Immunology, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 3INOVA Diagnostics, Inc, San Diego, China, 4Werfen China, Shanghai, China

    Background/Purpose: , Methods: , Results: and Conclusion: Background/Purpose:The antiphospholipid syndrome (APS) is a thrombophilic disorder characterized by clinical manifestations of vascular thrombosis and obstetric complications…
  • Abstract Number: 2 • 2017 ACR/ARHP Annual Meeting

    Identifying “Second Hit” Risk Factor(s) Associated with Thrombosis and Pregnancy Morbidity in Ethnically Diverse Antiphospholipid Antibodies Positive Patients

    Yu Zuo1, Jennifer Fan2, Ravi Sarode1, Song Zhang2, Una E. Makris1, David Karp3 and Yu-min Shen2, 1University of Texas Southwestern Medical Center, Dallas, TX, 2University of Texas Southwestern Medical Center, dallas, TX, 3Rheumatology, UT Southwestern Med Ctr, Dallas, TX

    Background/Purpose: The evaluation of thrombotic and pregnancy risks associated with antiphospholipid antibodies (aPL) in individual patients without APS clinical manifestation is challenging. Our aim is…
  • Abstract Number: 5 • 2017 ACR/ARHP Annual Meeting

    Clinical Utility of the Global Antiphospholipid Syndrome Score (GAPSS) for Risk Stratification: A Pooled Analysisfrom 2273 Patients

    Savino Sciascia1, Massimo Radin2, Giovanni Sanna3, Irene Cecchi4, Dario Roccatello5 and Maria Laura Bertolaccini6, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, London, United Kingdom, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, United Kingdom, London, United Kingdom

    Background/Purpose: Recently, our group conceived a risk score for clinical manifestations of APS [the global APS score or GAPSS] that takes into account the combination…
  • Abstract Number: 6 • 2017 ACR/ARHP Annual Meeting

    Pregnancy  Outcomes in a Cohort of Women with Antiphospholipid Syndrome. 25- Years  Long-Term Observation 

    Dana Tegzova1, Katerina Andelova2, Iva Kucerova2, Vera Vlasakova3, Stejskal Jan4, Putova Ivana5, Marta Olejarova6 and Ctibor Dostál7, 1Clinical Department, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, 2Institute of Mother and Child Care, Prague, Prague, Czech Republic, 3Dept.of Internal Medicine, City Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic, 41st Medical Faculty, Dpt. of Pathology, Charles University, Prague, Czech Republic, 5Institute of Rheumatology, Dpt. of Immunology, Prague, Czech Republic, 6Clinical, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, 7Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic

    Background/Purpose: The goal of this long-term project was to investigate the course of pregnancy in patients with APS (primary or secondary with SLE) in 1993-2017,…
  • Abstract Number: 1071 • 2016 ACR/ARHP Annual Meeting

    Anti-β2GP-I-Domain 3 and Aps/PT-IgG Antibodies Identify Primary APS Patients with Both Thrombotic and Hematological Manifestations

    Diego Hernández-Ramírez1, Gabriela Hernandez-Molina2, Carlos Núñez-Álvarez3, Miguel Astudillo-Angel4, Carlos Pacheco1, Elizabeth Olivares-Martínez1 and Antonio R. Cabral5, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 3Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Mexico city, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 5Department of Medicine. Division of Rheumatology, The Ottawa Hospital.University of Ottawa, Ottawa, ON, Canada

    Background/Purpose: Thrombocytopenia and hemolytic anemia (HA) are considered non-criteria clinical manifestations by the Sydney revised criteria for APS. These features can precede, follow a thrombotic…
  • Abstract Number: 1072 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking Registry Analysis: Cardiovascular Risk Factors Among Different Groups of Antiphospholipid Antibody-Positive Patients

    Ozan Unlu1, Doruk Erkan2, Maria Tektonidou3 and On Behalf of APS ACTION .4, 1Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 2Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 3First Department of Internal Medicine, School of Medicine, National University of Athens, Athens, Greece, 4., New York, NY

    Background/Purpose: Traditional cardiovascular disease (CVD) risk factors increase the risk of thrombotic clinical manifestations in antiphospholipid antibody (aPL)-positive patients.  The prevalence of CVD risk factors…
  • Abstract Number: 1962 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Neutrophils Are Characterized By Overexpression of P-Selectin Glycoprotein Ligand 1, a Potential Therapeutic Target

    Jason S Knight1, Patrick S. Coit1, He Meng1, Srilakshmi Yalavarthi1, Paul Renauer1, Robert C Grenn1, Levi F Mazza1, Hui Wang2, Daniel T Eitzman2 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI

    Background/Purpose:  Treatment of the thrombotic manifestations of antiphospholipid syndrome (APS) primarily focuses on inhibiting clotting pathways. In an effort to identify upstream inflammatory targets that…
  • Abstract Number: 1965 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking Registry Analysis: First and Recurrent Thrombosis Risk after 720 Patient-Years of Follow-up

    Ozan Unlu1, W. David Branch2, Paul R. Fortin3, Maria Gerosa4, Guillermo J. Pons-Estel5, Maria Tektonidou6, Amaia Ugarte7, Doruk Erkan8 and On Behalf of APS ACTION .9, 1Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 2Obstetrics and Gynecology, University of Utah and Intermountain Healthcare, Salt Lake City, UT, 3Medicine, CHU de Québec - Université Laval, Québec, QC, Canada, 4University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, 5Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, 6First Department of Internal Medicine, School of Medicine, National University of Athens, Athens, Greece, 7Hospital Universitario Cruces, Biscay, Spain, 8Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 9., New York, NY

    Background/Purpose: APS ACTION Registry was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients. Previously, based on…
  • Abstract Number: 2086 • 2016 ACR/ARHP Annual Meeting

    Hexagonal Phase Phospholipid Neutralization Assay Is the Most Sensitive but Least Specific Among Nine Tests for Detecting APS in SLE or Non-SLE Patients

    Katalin Banki1, Phillip Aleksiejuk2, Jessica Patel2 and Andras Perl3, 1Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, 2Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, 3Department of Medicine, Upstate Medical University, Syracuse, NY

    Background/Purpose: Antiphospholipid antibody syndrome (APS) is an autoimmune, hypercoagulable state which may elicit thrombosis and pregnancy loss.  Although several tests exist to guide diagnosis of…
  • Abstract Number: 2087 • 2016 ACR/ARHP Annual Meeting

    A Type I Interferon Signature in Monocytes and Decreased Levels of Circulating Plasmacytoid Dendritic Cells in Patients with Primary Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Ruth D.E. Fritsch-Stork2, Marjan A. Versnel3, Ronald H.W.M. Derksen4, Joel A.G. van Roon5,6 and Timothy R.D.J. Radstake5,6, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 4Departments of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 6Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands

    Background/Purpose: In several autoimmune diseases, most notably in systemic lupus erythematosus (SLE), a type I interferon (IFN) signature has been described. This signature is thought…
  • Abstract Number: 2090 • 2016 ACR/ARHP Annual Meeting

    Investigating the Genetic Variations of Antiphospholipid Syndrome By High-Throughput Exome Sequencing

    Sung-Hoon Park1, Chan Uk Lee1, Ji Na Kim2, Ji-Won Kim1, Hwajeong Lee2, Seong-Kyu Kim2 and Jung-Yoon Choe1, 1Medicine, Catholic university of Daegu School of medicine, Daegu, Korea, The Republic of, 2Catholic university of Daegu School of medicine, Daegu, Korea, The Republic of

    Background/Purpose:  The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies in serum together with clinical manifestations such as thrombosis,…
  • Abstract Number: 2092 • 2016 ACR/ARHP Annual Meeting

    Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 Is Elevated in Patients with Thrombotic Primary Antiphospholipid Syndrome.  

    Yair Molad1,2, Yonatan Edel3,4, Yael Pri-Paz Basson5, Elisheva Pokroy-Shapira6, Shirly Oren5, Ariela Dortort5 and Vitaly Kliminski4,7, 1Rheumatology Unit, Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel, 2Laboratory of Inflammation Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, 3Department of Medicine C, Beilinson Hospital, Rabib Medical Center, Petach Tikva, Israel, 4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 5Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel, 6Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel, 7Laboratory of Inflammation Research, Felsenstein Medical Research Center, Rabin Medical Center, Petach Tikva, Israel

    Background/Purpose : Primary antiphospholipid syndrome (PAPS) is characterized by thrombotic and/or obstetrical morbidity in the presence of persistent antiphospholipid antibodies (APLA) and in the absence…
  • Abstract Number: 2094 • 2016 ACR/ARHP Annual Meeting

    Complement Activation in Antiphospholipid Syndrome Due to the Multi-Activated Pathways of the Complement System

    Hiroyuki Nakamura1, Kenji Oku2, Ryo Hisada2, Kazumasa Ohmura2, Masaru Kato2, Toshiyuki Bohgaki2, Olga Amengual2, Tetsuya Horita2, Shinsuke Yasuda2 and Tatsuya Atsumi2, 1Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Background/Purpose:  Complement activation is proposed as one of the major thrombophilic mechanisms in antiphospholipid syndrome (APS). Among three complement pathways (classical, alternative and lectin), activation…
  • Abstract Number: 2095 • 2016 ACR/ARHP Annual Meeting

    Autoantibodies Against High Density Lipoprotein-Associated Proteins Are Related to Elevated Oxidized Low Density Lipoprotein Levels in Antiphospholipid Syndrome

    Kenji Oku1, Uhei Shibata2, Joana Batuca3, Olga Amengual4, Michihiro Kono2, Hiroyuki Nakamura5, Ryo Hisada1, Kazumasa Ohmura1, Masaru Kato2, Toshiyuki Bohgaki1, Shinsuke Yasuda1, Jose Delgado Alves3,6 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3CEDOC/NOVA Medical School, Lisbon, Portugal, 4Hokkaido University,Medicine II, Sapporo, Japan, 5Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 6Fernando Fonseca Hospital, Amadora, Portugal

    Background/Purpose: Oxidized low-density lipoprotein (oxLDL), a key molecule in atherogenesis, serves as the source of anionic charged particles that bind to beta2glycoprotein I (Β2GPI) and…
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