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Abstracts tagged "antiphospholipid syndrome"

  • Abstract Number: 15 • 2017 ACR/ARHP Annual Meeting

    Methodology and Systematic Review of the Literature for the Mcmaster RARE-Best Practice Clinical Practice Guideline on Diagnosis and Management of the Catastrophic Antiphospholipid Syndrome

    Kimberly Legault1, Christopher Hillis1, Cindy Yeung1, Elie Akl2, Marc Carrier3, Ricard Cervera4, Mark Crowther1, Francesco Dentali5, Doruk Erkan6, Gerard Espinosa7, Munther A Khamashta8, Joerg Meerpohl9, Karen Moffatt10, Sarah O'Brien11, Vittorio Pengo12, Jacob Rand13, Ignasi Rodriguez14, Lisa Thom15, Holger Schunemann1 and Alfonso Iorio1, 1McMaster University, Hamilton, ON, Canada, 2American University of Beirut, Beirut, Lebanon, 3University of Ottawa, Ottawa, ON, Canada, 4Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, 5Insubria University, Insubria, Italy, 6Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 7Autoimmune Diseases Department. Hospital Clínic de Barcelona, Barcelona, Spain, 8Graham Hughes Lupus Research Laboratory, The Rayne Institute, London, United Kingdom, 9University of Freiburg, Freiburg, Germany, 10Hamilton Health Sciences, Hamilton, ON, Canada, 11Nationwide Children's, Columbus, OH, 12Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, 13NY Presbyterian Hospital, New York, NY, 14Rheumatology, Hospital Clinica, Barcelona, Spain, 15None (patient representative), Oxford, United Kingdom

    Background/Purpose: Catastrophic antiphospholipid syndrome (CAPS), a rare disease, is characterized by the rapid onset of widespread thrombosis associated with multi-organ failure in patients meeting the…
  • Abstract Number: 17 • 2017 ACR/ARHP Annual Meeting

    Thrombotic Events in Pediatric Systemic Lupus Erythematosus: A Preliminary Analysis of a Large, Single-Center Cohort

    Jennifer Rammel1, Martha Curry2 and Marietta M. de Guzman3, 1Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, 2Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, 3Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: While pediatric systemic lupus erythematosus (pSLE) represents only 20% of all SLE cases, pSLE patients often have more aggressive disease with multi-organ involvement. These…
  • Abstract Number: 108 • 2017 ACR/ARHP Annual Meeting

    Impact of Antiphospholipid Syndrome Ibook on Medical Students’ Improvement of Knowledge: An International Randomized Controlled Experimental Study

    Stephane Zuily1, Laurent Phialy2, Eloïse Germain2, Ozan Unlu3, Virginie Dufrost4, Isabelle Clerc-Urmès4, Jessica R. Berman5, Michael Lockshin6, Denis Wahl7 and Doruk Erkan8, 1Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, CHRU de Nancy, Vascular Medicine Division and Regional Competence Center for Rare Vascular and Auto-Immune Diseases; Inserm U1116; Lorraine University, Nancy, France, 2Lorraine University, Nancy School of Medicine, Nancy, France, 3Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 4Nancy Academic Hospital, Nancy, France, 5Rheumatology, Hospital for Special Surgery, New York, NY, 6Hospital for Special Surgery, NYC, NY, 7CHU de Nancy, Vascular Medicine Division and Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases; and UMR_S U1116 Research Unit, Nancy, France, 8Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY

    Background/Purpose: iBooks, a free electronic book application by Apple, is well-suited for publishing interactive medical texts. To date, no iBook on Antiphospholipid Syndrome (APS) exists,…
  • Abstract Number: 1295 • 2017 ACR/ARHP Annual Meeting

    Pregnancy Outcome in Patients with SLE Compared to Patients with Other Inflammatory Rheumatic Diseases: Real World Data from a Prospective Pregnancy Register

    Rebecca Fischer-Betz1, Christina Bungartz2, Matthias Schneider1, Jutta Richter1, Anja Weiss2, Angela Zink3 and Anja Strangfeld4, 1Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany, 4Epidemiology, German Rheumatism Research Center, Berlin, Germany

    Background/Purpose: SLE pregnancies are complicated due to risk for maternal disease exacerbation and potential for fetal and neonatal complications. With careful pre-pregnancy counseling and monitoring…
  • Abstract Number: 2564 • 2017 ACR/ARHP Annual Meeting

    Inhibition of Neutrophil Elastase Protects Against Glomerulonephritis and Thrombosis in a Mouse Model of Lupus

    Gautam Sule1, Levi F. Mazza1, Nayef M. Kazzaz1, Srilakshmi Yalavarthi1, He Meng1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2., University of Michigan, Ann Arbor, MI

    Background/Purpose: Neutrophils are potential instigators of autoimmunity and effectors of organ damage in lupus. However, there is presently no consensus as to whether inhibition of…
  • Abstract Number: 2094 • 2016 ACR/ARHP Annual Meeting

    Complement Activation in Antiphospholipid Syndrome Due to the Multi-Activated Pathways of the Complement System

    Hiroyuki Nakamura1, Kenji Oku2, Ryo Hisada2, Kazumasa Ohmura2, Masaru Kato2, Toshiyuki Bohgaki2, Olga Amengual2, Tetsuya Horita2, Shinsuke Yasuda2 and Tatsuya Atsumi2, 1Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Background/Purpose:  Complement activation is proposed as one of the major thrombophilic mechanisms in antiphospholipid syndrome (APS). Among three complement pathways (classical, alternative and lectin), activation…
  • Abstract Number: 2095 • 2016 ACR/ARHP Annual Meeting

    Autoantibodies Against High Density Lipoprotein-Associated Proteins Are Related to Elevated Oxidized Low Density Lipoprotein Levels in Antiphospholipid Syndrome

    Kenji Oku1, Uhei Shibata2, Joana Batuca3, Olga Amengual4, Michihiro Kono2, Hiroyuki Nakamura5, Ryo Hisada1, Kazumasa Ohmura1, Masaru Kato2, Toshiyuki Bohgaki1, Shinsuke Yasuda1, Jose Delgado Alves3,6 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3CEDOC/NOVA Medical School, Lisbon, Portugal, 4Hokkaido University,Medicine II, Sapporo, Japan, 5Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 6Fernando Fonseca Hospital, Amadora, Portugal

    Background/Purpose: Oxidized low-density lipoprotein (oxLDL), a key molecule in atherogenesis, serves as the source of anionic charged particles that bind to beta2glycoprotein I (Β2GPI) and…
  • Abstract Number: 77 • 2016 ACR/ARHP Annual Meeting

    Integrated Analysis of Microrna and mRNA Expression Profiles Related to Cardiovascular Disease in Monocytes from Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome Patients

    Carlos Perez-Sanchez1, Maria Ángeles Aguirre Zamorano1, Patricia Ruiz-Limon2, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Maria Carmen Abalos-Aguilera2, Ivan Arias de la Rosa2, María Galindo3, Eduardo Collantes-Estévez1, Maria Jose Cuadrado4 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, 4St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: The interplay between miRNAs and their mRNA targets might constitute an important mechanism in the regulation of the proatherothrombotic status of SLE and APS…
  • Abstract Number: 2099 • 2016 ACR/ARHP Annual Meeting

    Micrornas As Potential Modulators of Atherothrombosis in Antiphospholipid Syndrome

    Patricia Ruiz-Limon1, Maria Ángeles Aguirre Zamorano2, Nuria Barbarroja2, Yolanda Jiménez-Gómez2, IVÁN ARIAS DE LA ROSA2, Eduardo Collantes-Estévez2, Pedro Segui2, Francisco Velasco3, Rocio Gonzalez-Conejero4, Raul Teruel4, Constantino Martinez4, Maria Jose Cuadrado5, Carlos Perez-Sanchez2 and Chary Lopez-Pedrera2, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Hematology, IMIBIC-Reina Sofia Hospital, Hematology Unit, Cordoba, Spain, 4Regional Centre for Blood Donation, University of Murcia, Murcia, Spain, 5St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: 1) To identify and characterize microRNAs linked to thrombosis and atherosclerosis development in APS; 2) To assess the effects of antiphospholipid antibodies in that…
  • Abstract Number: 920 • 2016 ACR/ARHP Annual Meeting

    Autoantigen-Specific T Cell and Antibody Reactivity to a Human Gut Commensal in Antiphospholipid Syndrome

    William Ruff1, Carina Dehner2, Alex Roth1, Silvio M. Vieira1, Cassyanne L. Aguiar3,4, Andrew Goodman5, Doruk Erkan6 and Martin Kriegel1, 1Immunobiology, Yale School of Medicine, New Haven, CT, 2Immunobiology, Yale School of Medicine, new haven, CT, 3Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 4Cohen Children's Medical Center of New York/ Hofstra Northwell School of Medicine, Pediatric Rheumatology, New York, NY, 5Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, 6Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY

    Autoantigen-specific T Cell and Antibody Reactivity to a Human Gut Commensal in Antiphospholipid Syndrome William Ruff1, Carina Dehner1, Alex Roth1, Silvio M. Vieira1, Cassyanne L.…
  • Abstract Number: 2875 • 2016 ACR/ARHP Annual Meeting

    Depressed Serum IgM Levels in SLE Are Restricted to Defined Subgroups

    Caroline Grönwall1, Uta Hardt1, Iva Gunnarsson2, Gregg J. Silverman3 and Elisabet Svenungsson1, 1Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Department of Medicine, Unit of Rheumatology, Stockholm, Sweden, 3Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Natural IgM autoantibodies have been proposed to have protective properties, and decreased levels of IgM to phosphorylcholine (PC) in SLE are associated with higher…
  • Abstract Number: 1059 • 2016 ACR/ARHP Annual Meeting

    Quality of Life in Patients with Antiphospholipid Syndrome Is Related to Disease Burden and Anticoagulant Therapy

    Gabriela Hernandez-Molina1, Itzel Gonzalez-Pérez2, Carlos Pacheco2 and Antonio R. Cabral3, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 3Department of Medicine. Division of Rheumatology, The Ottawa Hospital.University of Ottawa, Ottawa, ON, Canada

    Background/Purpose:  Few studies have reported impaired health related quality of life (HRQoL) in patients with primary antiphospholipid syndrome (APS); however the causes of this outcome…
  • Abstract Number: 1060 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Antibodies and Related Clinical Events Following Infection in Children: A Systematic Review of Case Reports

    Noha Abdel-Wahab1, Maria A. Lopez-Olivo2 and Maria Suarez-Almazor3, 1Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Rheumatology and Rehabilitation Department, Assiut University Hospitals, Assiut, Egypt, Houston, TX, 2Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine,The University of Texas MD Anderson Cancer Center, Houston, Texas, USA,, Houston, TX, 3Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX

    Background/Purpose: A systematic review of case reports to summarize existing evidence in the literature regarding the association of APS and infection during childhood. Our aims…
  • Abstract Number: 1062 • 2016 ACR/ARHP Annual Meeting

    Non-Conventional Antiphospholipid Antibodies in Patients with Clinical Obstetrical APS: Prevalence and Pregnancies Treatment Efficacy

    ARSENE MEKINIAN1, Marie Charlotte Bourrienne2, LIONEL CARBILLON3, AMELIE BENBARA4, SYLVIE CHOLLET MARTIN5, AHMED TIGAIZIN3, Francois Montestruc6, Olivier Fain7 and Pascale Nicaise-Roland8, 1SAINT ANTOINE HOSPITAL, PARIS, France, 2Unité Fonctionnelles d'Immunologie « Autoimmunité et Hypersensibilités », AP-HP, Hôpital Bichat-Claude Bernard, Paris, paris, France, 3JEAN VERDIER HOSPITAL, BONDY, France, 4JEAN VERDIER HOSPITAL, PARIS, France, 5UNITE HYPERSENSIBILITE, PARIS, France, 6exystat, PARis, France, 7Internal Medicine Department, Saint Antoine Hospital, Paris, France, 8Immunology Department, Bichat Claude-bernard, Universitary Hospital, APHP, Paris, France

    Background/Purpose: To describe the prevalence of non-conventional APL in patients with obstetrical APS pregnancy adverse outcome without conventional APL and the impact of treatment on…
  • Abstract Number: 1068 • 2016 ACR/ARHP Annual Meeting

    Recurrence of  Thrombosis Despite Negativization of Antiphospholipid Antibodies in Primary Antiphospholipid Syndrome. a Follow-up to 5 Years

    Gabriela Medina1, Eduardo Briones-Garcia2, Pilar Cruz-Dominguez3, Oscar I Florez-Durante4, Olga-Lidia Vera-Lastra5, Miguel A. Saavedra6 and Luis J. Jara7, 1Clinical research unit, Hospital de Especialidades Centro Medico La Raza,IMSS, Mexico City, Mexico, 2Direction of Education and Research, Clinical Research Unit, Mexico, Mexico, 3Research Division, Hospital de Especialidades, Centro Médico La Raza, IMSS, Mexico, Mexico, 4Clinical researh Unit, Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional, Mexico, Mexico, 5Rheumatology, Inst Mexicano Seguro Social, Mexico City, Mexico, 6Rheumatology, Centro Médico Nacional La Raza IMSS, México, Mexico, 7Direction of education and research, Hospital de Especialidades Centro Medico La Raza, Mexico City, Mexico

    Background/Purpose: In some antiphospholipid syndrome (APS) patients, the antiphospholipid antibodies (aPL) becomes persistently negative. Discontinuation of anticoagulation has been proposed, however the long term follow-up…
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