Abstracts tagged "Antioxidants"

Abstract Number: 1058 • 2018 ACR/ARHP Annual Meeting
Doxycycline Directly Scavenges Reactive Oxygen Species and Inhibits the Formation of Malondialdehyde-Acetaldehyde-Protein Adducts – a Novel Mechanism of Action for an Old Drug
Andrew Chiou¹, Michael J. Duryee¹, Dahn L Clemens², Cleofes Sarmiento², Matthew Zimmerman³, Carlos D. Hunter¹, Lynell W. Klassen⁴, James R. O'Dell⁴, Daniel R. Anderson², Ted R. Mikuls⁵ and Geoffrey M. Thiele², ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Oxidative stress plays a role in the progression of inflammatory diseases such as Rheumatoid Arthritis (RA) due to the imbalance between levels of reactive…
Abstract Number: 2261 • 2016 ACR/ARHP Annual Meeting
Methotrexate Inhibits Intracellular Redox Signaling Induced By the Reactive Oxygen Species; Malondialdehyde and Acetaldehyde
Andrew Chiou¹, Michael J. Duryee^1,2, Cleofes Sarmiento³, Matthew Zimmerman⁴, Carlos D. Hunter¹, Lynell W. Klassen⁵, James R. O'Dell⁵, Daniel R. Anderson³, Geoffrey M. Thiele³ and Ted R Mikuls⁶, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Research Services, Omaha VA Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁵Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Inflammatory diseases such as rheumatoid arthritis (RA) are associated with oxidative stress as a result of elevated levels of reactive oxygen species (ROS). Oxidative…
Abstract Number: 2199 • 2015 ACR/ARHP Annual Meeting
in Vivo Ubiquinol Supplementation Reduces the Pro-Atherothrombotic Status in Antiphospholipid Syndrome Patients. Preliminary Results of a Clinical Trial
Chary Lopez-Pedrera¹, Maria Ángeles Aguirre Zamorano¹, Francisco Velasco², Patricia Ruiz-Limon¹, Nuria Barbarroja¹, Yolanda Jiménez Gómez¹, Maria Carmen Abalos-Aguilera¹, Pedro Segui³, Eduardo Collantes-Estevez¹, Lucia Fernandez-del Rio⁴, Jose Antonio Gonzalez-Reyes⁴, Jose Manuel Villalba⁴, Mª Jose Cuadrado⁵ and Carlos Perez-Sanchez¹, ¹IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, ²Hematology, IMIBIC-Reina Sofia Hospital, Hematology Unit, Cordoba, Spain, ³IMIBIC-Reina Sofia University Hospital, Radiology Unit, Cordoba, Spain, ⁴Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, ⁵Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom
Background/Purpose: To investigate the beneficial effects of in vivoubiquinol (Q, reduced form of CoQ10) supplementation on athero-thrombosis prevention in APS patients, through the implementation of…
Abstract Number: 2710 • 2015 ACR/ARHP Annual Meeting
Necrox-7 Inhibits Cell Aggressiveness By Suppressing of NF-Kappa B Activation and Reactive Oxygen Species Generation in Human Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyun Jung Yoo^1,2, Jin Kyun Park², Eun Young Lee², Eun Bong Lee² and Yeong Wook Song^2,3, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component…
Abstract Number: 2020 • 2014 ACR/ARHP Annual Meeting
Circulating Carotenoids and Subsequent Risk of Rheumatoid Arthritis
Yang Hu¹, Karen H. Costenbader², Elizabeth W. Karlson² and Bing Lu², ¹Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Antioxidant components in food may be biologically relevant to the prevention of rheumatoid arthritis (RA). Evidence from prospective cohort studies regarding the relationship between…
Abstract Number: 35 • 2014 ACR/ARHP Annual Meeting
Hydrogen Sulfide Inhibits Human Osteoclast Differentiation in Vitro By Triggering Sustained Antioxidant Response and Inhibiting the RANKL/OPG Ratio
Francesco Grassi¹, Laura Gambari², Andrea Facchini³ and Gina Lisignoli⁴, ¹LAB. RAMSES, ISTITUTO ORTOPEDICO RIZZOLI, BOLOGNA, Italy, ²Lab. RAMSES, ISTITUTO ORTOPEDICO RIZZOLI, BOLOGNA, Italy, ³Lab of Immunorheumatology and Tissue Regeneration, ISTITUTO ORTOPEDICO RIZZOLI, BOLOGNA, Italy, ⁴LAB. OF IMMUNORHEUMATOLOGY AND TISSUE REGENERATION, ISTITUTO ORTOPEDICO RIZZOLI, BOLOGNA, Italy
Background/Purpose Hydrogen sulfide (H2S) has been recently appreciated as a novel gasotransmitter with an important role in the regulation of tissues and organs. H2S is…
Abstract Number: 34 • 2012 ACR/ARHP Annual Meeting
Rebamipide Attenuates Pain Severity and Cartilage Degeneration in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes
Su-Jin Moon¹, Mi-La Cho², Yeon-Sik Hong³, Sung-Hwan Park⁴ and Jun-Ki Min¹, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ³Our Lady of Mercy Hospital, Inchon, South Africa, ⁴Catholic University of Korea, Seoul, South Korea
Background/Purpose: The development and progression of osteoarthritis (OA) are now believed to involve inflammation, even in the early stage of disease. Proinflammatory cytokines and chemokines are…

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