Abstracts tagged "antioxidant and MRL-lpr mouse"

Abstract Number: 69 • 2019 ACR/ARP Annual Meeting
Treatment of Lupus-prone MRL-lpr Mice with the Mitochondrial Antioxidant MitoQ
Ralph Budd¹, Karen Fortner ¹, Luz Blanco ², Mariana Kaplan ³, Andras Perl ⁴, Iwona Busliewicz ⁵, Greg MacPherson ⁶ and Mike Murphy ⁷, ¹The University of Vermont Larner College of Medicine, Burlington, VT, ²NIH NIAMS, Bethesda, MD, ³National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, ⁴SUNY Upstate Medical University, Syracuse, NY, ⁵Upstate Medical Center, Syracuse, NY, ⁶MitoQ, Aukland, New Zealand, ⁷Wellcome MRC Mitochondrial Biology Unit, Cambridge, United Kingdom
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by a type I Interferon (IFN-I) gene signature in peripheral blood lymphocytes (PBL), which contain enlarged mitochondria and…

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Abstracts tagged "antioxidant and MRL-lpr mouse"

Treatment of Lupus-prone MRL-lpr Mice with the Mitochondrial Antioxidant MitoQ