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Abstracts tagged "antigen-presenting cells and tolerance"

  • Abstract Number: 723 • 2013 ACR/ARHP Annual Meeting

    Abatacept Is Highly Effective At Inhibiting T Cell Priming and Induces a Unique Transcriptional Profile In CD4+ t Cells

    Agapitos Patakas1, Rui-Ru Ji2, William Weir3, Sean Connolly2, Steven G. Nadler2, James M. Brewer4, Iain B. McInnes4 and Paul Garside4, 1Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Department of Immunology and Inflammation, Bristol Myers Squibb Co. Research and Development, Princeton, NJ, 3Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom, 4Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Absence of co-stimulation in the presence of TCR-stimulation has been proposed to induce tolerance via deletion or anergy.    Abatacept is a CTLA-4-Ig molecule that…
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ACR Pediatric Rheumatology Symposium 2020

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