Abstracts tagged "antigen-presenting cells and myositis"

Abstract Number: 269 • 2016 ACR/ARHP Annual Meeting
The Immunoproteasomes Are Essential for Maintaining Myokine Production and MHC Class I Expression in Idiopathic Inflammatory Myopathies
Salyan Bhattarai¹, Khetam Ghannam¹, Sabine Krause², Olivier Benveniste³, Andreas Marg⁴, Gerjan de Bruin⁵, Bo-Tao Xin⁵, Herman S Overkleeft⁶, Simone Spuler⁷, Werner Stenzel⁷ and Eugen Feist⁷, ¹Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany, ²Friedrich Baur Institute, Ludwig Maximilians University, Munich, Germany, ³Pitié-Salpêtrière University Hospital, Paris, France, ⁴Muscle Research Unit, Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany, ⁵Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands, ⁶Leiden University, Leiden, Netherlands, ⁷Charité-Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Idiopathic inflammatory myopathies (IIMs) are muscle diseases, characterized by inflammatory infiltration and increased expression of MHC class I molecules on myofibers. Immunoproteasome, as a…

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