ACR Meeting Abstracts

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Abstracts tagged "antigen-presenting cells"

  • Abstract Number: 2747 • 2019 ACR/ARP Annual Meeting

    Identification of Naturally Presented Peptides of the Autoantigen Topoisomerase-I Reveals a Common Pathogenic Mechanism in Patients with Systemic Sclerosis

    Eleni Tiniakou1, Andrea Fava 2, Zsuzsanna McMahan* 3, Tara Gurh 4, Robert O'Meally 4, Ami Shah 5, Frederick Wigley 3, Robert Cole 4, Francesco Boin 6 and Erika Darrah 1, 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Johns Hopkins University, Division of Rheumatology, Baltimore, 4Johns Hopkins University, Baltimore, 5Johns Hopkins Hospital, Baltimore, MD, 6UCSF, San Francisco, CA

    Background/Purpose: Autoimmune responses to DNA topoisomerase-I (TOP1) are found in a subset of patients with scleroderma at high risk for interstitial lung disease (ILD) and…
  • Abstract Number: 852 • 2018 ACR/ARHP Annual Meeting

    Antigenic Property of Prothrombin/HLA-DR Complex on Procoagulant Cells in Patients with Antiphospholipid Syndrome

    Naoki Ohnishi1, Yuichiro Fujieda1, Ryo Hisada1, Hiroyuki Nakamura1, Masaru Kato1, Kenji Oku1, Toshiyuki Bohgaki1, Olga Amengual1, Shinsuke Yasuda1, Hisashi Arase2 and Tatsuya Atsumi1, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 2Department of Immunochemistry, Research Institute for Microbial Disease, Osaka University, Suita, Japan

    Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL). Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) recognize the phosphatidylserine/prothrombin…
  • Abstract Number: 2880 • 2016 ACR/ARHP Annual Meeting

    Distinct Metabolic Pathways Regulate Lipid Antigen Presentation By Monocytes and B Cells: Implications for SLE Patients with Pre-Clinical Atherosclerotic Plaque

    Kirsty Waddington1, Edward Smith2, Sara Croca3, David A. Isenberg4, Anisur Rahman5, Ines Pineda Torra6 and Elizabeth Jury7, 1Clinical Pharmacology and Rheumatology, University College London, London, United Kingdom, 2Centre for Rheumatology Research, University College London, London, United Kingdom, 3Rheumatology, University College London, London, United Kingdom, 4Centre for Rheumatology Research, University College Hospital London, UK, London, United Kingdom, 5Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 6Clinical Pharmacology, University College London, London, United Kingdom, 7Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom

    Background/Purpose:  Systemic lupus erythematosus (SLE) patients have an increased risk of developing clinically apparent cardiovascular disease (CVD) and subclinical atherosclerotic plaque, detectable by vascular ultrasound…
  • Abstract Number: 2935 • 2016 ACR/ARHP Annual Meeting

    Activation Status of Mucosal-Associated Invariant T Cells Sensitively Reflects Disease Activity of Systemic Lupus Erythematosus

    Asako Chiba1, Goh Murayama2, Mie Kitagaichi3, Naoto Tamura4, Ken Yamaji2, Yoshinari Takasaki4 and Sachiko Miyake1, 1Immunology, Juntendo University School of Medicine, Tokyo, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 4Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
  • Abstract Number: 3027 • 2015 ACR/ARHP Annual Meeting

    Hyperactivated State of Mucosal Associated Invariant T Cells Due to Activation Potency of Monocytes in Systemic Lupus Erythematous

    Goh Murayama1, Asako Chiba2, Ken Yamaji3, Naoto Tamura3, Yoshinari Takasaki3 and Sachiko Miyake2, 1Department of Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, 2Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, 3Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
  • Abstract Number: 992 • 2014 ACR/ARHP Annual Meeting

    Differential Antigen-Presenting B-Cell Phenotype from Synovial Microenvironment of Rheumatoid Arthritis and Psoriatic Arthritis Patients

    Estefania Armas-Gonzalez1, Ana Diaz-Martin1, María Jesús Dominguez-Luis2, Maria Teresa Arce-Franco1, Ada Herrera-Garcia1, Vanesa Hernandez1, Alicia Usategui3, Jose L. Pablos4, Juan D. Cañete5, Sagrario Bustabad1 and Federico Díaz-González1, 1Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, 2Center of Biomedical Research of the Canary Islands, University of La Laguna, Tenerife, Spain, 3Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 4Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 5Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain

    Background/Purpose The systemic depletion of B cells induced by mabthera, a monoclonal antibody against human CD20, has shown to be an effective therapy for controlling…
  • Abstract Number: 2745 • 2013 ACR/ARHP Annual Meeting

    Reshaping Inflammatory Macrophage Development and Functions by a Monosaccharide Analogue In Rheumatoid Arthritis

    Jun Li1, Hui-Chen Hsu2,3, PingAr Yang1, Qi Wu1, Bao Luo1, Amber L Rowse4, David M. Spalding5, James A Mobley6, S. Louis Bridges Jr.7 and John D. Mountz3,8, 1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Birmingham VA Medical Center, Birmingham, AL, 4Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, 6University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, 7University of Alabama at Birmingham, Birmingham, AL, 8Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Inflammatory macrophages (MΦs) play key roles in pathogenesis of rheumatoid arthritis (RA). Fucosylation, comprising the transfer of a fucose (6-Deoxy-L-galactose) to proteins, is regulated…
  • Abstract Number: 1143 • 2013 ACR/ARHP Annual Meeting

    Increased Frequency Of Pratroling Monocytes In Experimental Arthritis and Rheumatoid Arthritis Patients In Response To IL6-R Blockade

    Julie Quentin1, Jessy Presumey2, Florence Apparailly2, Yves-Marie Pers3, Pascale Louis Plence4 and Christian Jorgensen3, 1Inserm U844, Montpellier, France, 2U844, Inserm, Montpellier, France, 3Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, 4INSERM U844 Montpellier, Montpellier, France

    Background/Purpose: Monocytes represent a heterogeneous circulating population of immune cells that play important roles in the inflammatory response. Two main functional subsets of human monocytes…
  • Abstract Number: 916 • 2013 ACR/ARHP Annual Meeting

    Role Of CD20+ B Cells As Antigen-Presenting Cells In Arthritis

    Estefania Armas-Gonzalez1, Ana Diaz-Martin1, María Jesús Dominguez-Luis1, Maria Teresa Arce-Franco1, Ada Herrera-Garcia1, Vanesa Hernandez1, Alicia Usategui2, Jose L. Pablos3, Sagrario Bustabad1 and Federico Diaz-Gonzalez4, 1Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, 2Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain, 3Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 4University of La Laguna, Hospital Universitario de Canarias, La Laguna, Spain

    Background/Purpose: B cells participate in the pathogenesis of rheumatoid arthritis (RA) through a mechanism still not fully understood. In RA, B cells are believed to…
  • Abstract Number: 1055 • 2012 ACR/ARHP Annual Meeting

    Sec61 Is Indispensable for Antigen Cross-Presentation and the Development of Lupus Nephritis: A Novel ‘Self-Organized Criticality Theory’ Explaining the Cause of Systemic Lupus Erythematosus (SLE)

    Ken Tsumiyama and Shunichi Shiozawa, Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose:  We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
  • Abstract Number: 1072 • 2012 ACR/ARHP Annual Meeting

    Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function

    Stefan Uderhardt1, Tobias Rothe1, Elisabeth Zinser2, Olga Oskolkova3, Martin Herrmann4, Alexander Steinkasserer5, Valery Bochkov3, Georg Schett6 and Gerhard Kronke1, 1Internal Medicine 3, University of Erlangen, Erlangen, Germany, 2University of Erlangen, Erlangen, Germany, 3Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 4Instiute for Immunology, PhD, Erlangen, Germany, 5Department of Immune Modulation at the Department of Dermatology, University Hospital Erlangen, Erlangen, Germany, 6Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: During inflammation and tissue damage, pathogens as well as dying cells are ingested by different phagocytes such as macrophages and dendritic cells. The uptake…
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