Abstracts tagged "Anticardiolipin"

Abstract Number: 12 • 2013 ACR/ARHP Annual Meeting
Phosphatidiyserine-Prothrombin Complex (aPS/PT) IgG Antibodies Correlate With Lupus Anticoagulant and Specific Pregnancy Complications In Patients With Antiphospholipid Syndrome
Rohan Willis¹, Anne E. Tebo², Gabriella Lakos³, Michael Mahler³, Gary L. Norman³, Ware D. Branch⁴, Jane Salmon⁵, Marta M. Guerra⁶ and Silvia S. Pierangeli⁷, ¹Int Medicine/Rheumatology, University of Texas Medical Branch, Galveston, TX, ²Pathology, University of Utah, Salt Lake City, UT, ³Research, INOVA Diagnostics, San Diego, CA, ⁴Obsterics and Gynecology, Univ of Utah, Salt Lake City, UT, ⁵Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Rheumatology 3rd Fl Rsrch, Hospital for Special Surgery, New York, NY, ⁷Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX
Background/Purpose: Criteria laboratory tests for antiphospholipid syndrome (APS) include lupus anticoagulant (LAC) as well as IgG and IgM antibodies for cardiolipin and beta2 glycoprotein. Of…
Abstract Number: 13 • 2013 ACR/ARHP Annual Meeting
A MORE Specific Immunoassay For The Diagnosis Of APS
Claudia Grossi¹, Maria Borghi¹, Elizabeth Papalardo², Silvia S. Pierangeli³ and Pier Luigi Meroni⁴, ¹Lab of immunology, IRCCS Istituto Auxologico Italiano, Milano, Italy, ²Louisville APL Diagnostics, Inc, Seabrook, TX, ³Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ⁴Chair and Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy
Background/Purpose: Anticardiolipin (aCL) antibody assays are sensitive for the detection of antiphospholipid antibodies (aPL) in patients with the Antiphospholipid syndrome (APS) but are known to…
Abstract Number: 1736 • 2012 ACR/ARHP Annual Meeting
The Estimated Prevalence of Antiphospholipid Antibodies in the General Population with Pregnancy Morbidity
Cecilia B. Chighizola¹, Guilherme Ramires de Jesus², Laura Andreoli³, Alessandra Banzato⁴, Guillermo J. Pons-Estel⁵, Michael D. Lockshin⁶, Doruk Erkan⁷ and On Behalf of APS Action⁸, ¹Rheumatology, Istituto Auxologico Italiano, University of Milan, Milan, Italy, ²Department of Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ³Rheumatology Unit, University of Brescia, Brescia, Italy, ⁴Department of Cardiac Thoracic and Vascular Sciences, (2) Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua Italy, Padua, Italy, ⁵Servicio de Enfermedades Autoinmunes, (4) Department of Autoimmune Diseases, Institut Clìnic de Medicina i Dermatologia, Hospital Clìnic, Barcelona, Spain, ⁶Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸APS ACTION, New York, NY
Background/Purpose: AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) is an international research network created to conduct well-designed clinical trials in persistently…
Abstract Number: 2455 • 2012 ACR/ARHP Annual Meeting
Establishment of Standardized International Units for IgG Anti-β₂glycoprotein Antibody Measurement
Rohan Willis¹, Claudia Grossi², Gabriella Lakos³, Pier Luigi Meroni⁴, Maria Borghi², Luis R. Lopez⁵, Corina Dima⁶, Marius C. Teodorescu⁷, Nicholas Ozarka⁷, Matthias Kast⁸, Nina Olschowka⁸, Alfredo Villarreal⁹, Maria Crisostomo¹⁰, Mike Watkins⁹, Wendy Vandam¹¹, Tony Prestigiacomo¹¹, Josep Puig¹², Kerrie Jaskal¹³, Roger Walker¹⁰, Sarah Paul⁹, T. Buckner¹⁴, Fernando S. Cavalcanti¹² and Silvia S. Pierangeli¹⁵, ¹Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ²Lab of immunology, IRCCS Istituto Auxologico Italiano, Milano, Italy, ³Research, INOVA Diagnostics, San Diego, CA, ⁴Chair and Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy, ⁵Corgenix Inc, Broomfield, CO, ⁶Microbiology, Theratest Laboratories Inc, Lombard, IL, ⁷Microbiology, TheraTest Laboratories Inc, Lombard, IL, ⁸Phadia Thermofisher, Freiburg, MN, Germany, ⁹BioPlex Division, Bio-Rad Laboratories, Benicia, CA, ¹⁰Bio-rad Laboriatories, In, Bio-Rad Laboratories, Hercules, CA, ¹¹Bio-Rad Laboratories, Hercules, CA, ¹²Biokit, Barcelona, Spain, ¹³Instrumentation Laboratories, Bedford, MA, ¹⁴Corgenix, Broomfield, CO, ¹⁵Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX
Background/Purpose: Despite numerous efforts aimed at the standardization of assays for detection of anti-β2Glycoprotein I (aβ2GPI)antibodies, there are still concerns, including the type and…
Abstract Number: 2456 • 2012 ACR/ARHP Annual Meeting
Pro-Inflammatory and Pro-Thrombotic Markers in Persistently Antiphospholipid Antibody-Positive Patients with/without Systemic Lupus Erythematosus
Gurjot Basra¹, Doruk Erkan², Rohan Willis¹, JoAnn Vega³, Ana Laura Carrera Marin⁴, Patricia Ruiz Limon¹, Vijaya L. Murthy¹, Shraddha Jatwani¹, Neha Dang¹, Emilio B. Gonzalez¹ and Silvia S. Pierangeli⁴, ¹Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Research, Hospital for Special Surgery, New York, NY, ⁴Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX
Background/Purpose: Pro-inflammatory/thrombotic biomarkers (BMR), which are associated with aPL-mediated pathogenic effects in vitro/vivo, are also increased in aPL-positive patients. Here we examined whether those BMR…
Abstract Number: 2457 • 2012 ACR/ARHP Annual Meeting
An Open-Label Prospective Pilot Mechanistic Study of Fluvastatin in Persistently Antiphospholipid Antibody-Positive Patients
Doruk Erkan¹, Rohan Willis², JoAnn Vega³, Vijaya L. Murthy², Ana Laura Carrera Marin⁴, Gurjot Basra², Patricia Ruiz Limon², Emilio B. Gonzalez² and Silvia S. Pierangeli², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ³Research, Hospital for Special Surgery, New York, NY, ⁴Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX
Background/Purpose: Antiphospholipid antibodies (aPL) induce a pro-inflammatory and pro-thrombotic state by upregulating various cytokines, chemokines, and tissue factor (TF). Fluvastatin reduces TF expression and decrease…
Abstract Number: 1731 • 2012 ACR/ARHP Annual Meeting
IgA Anti-β₂glycoprotein I Antibodies Are Pathogenic in a Mouse Model of APS
Patricia Ruiz Limon¹, Zurina Romay-Penabad², Ana Laura Carrera Marin³, Elizabeth Papalardo⁴ and Silvia S. Pierangeli³, ¹Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ²Rheumatology/Dept Int Med, Univ of TX Medical Branch, Galveston, TX, ³Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ⁴Louisville APL Diagnostics, Inc, Seabrook, TX
Background/Purpose: Recently exclusive IgA anti-b2Glycoprotein I (ab2GPI) seropositivity - in the absence of any other antiphospholipid (aPL) antibodies- has been reported particularly in SLE patients. …

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