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Abstracts tagged "antibodies and tolerance"

  • Abstract Number: 46 • ACR/ARHP Annual Meeting 2017

    Secondary Light Chain Editing and Allelic Inclusion in Antibody Secreting Cells from the Minor Salivary Gland

    Kristi A. Koelsch1, Kenneth Smith2, Astrid Rasmussen3, C. Erick Kaufman4, David M. Lewis5, Lida Radfar6, Christopher J Lessard2, Biji T Kurien2, Judith A. James3, Kathy L. Sivils3, A. Darise Farris7 and R. Hal Scofield8, 1Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 5Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 6Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 7Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 8Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Heavy and light chain gene usage and mutational analyses of the Ig variable regions (V-regions) enable the identification of gene usage within B cell…

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