Abstracts tagged "antibodies and tolerance"

Abstract Number: 46 • 2017 ACR/ARHP Annual Meeting
Secondary Light Chain Editing and Allelic Inclusion in Antibody Secreting Cells from the Minor Salivary Gland
Kristi A. Koelsch¹, Kenneth Smith², Astrid Rasmussen³, C. Erick Kaufman⁴, David M. Lewis⁵, Lida Radfar⁶, Christopher J Lessard², Biji T Kurien², Judith A. James³, Kathy L. Sivils³, A. Darise Farris⁷ and R. Hal Scofield⁸, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ⁵Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Heavy and light chain gene usage and mutational analyses of the Ig variable regions (V-regions) enable the identification of gene usage within B cell…