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Abstracts tagged "antibodies and tofacitinib"

  • Abstract Number: 1650 • ACR/ARHP Annual Meeting 2016

    Treatment with Tofacitinib Inhibits Human Naive B Lymphocyte Development and Function in Vitro

    Jens Thiel1, Nils Venhoff2, Raquel Lorenzetti3, Bettina Bannert1, Reinhard Voll4, Diego Kyburz5 and Marta Rizzi1, 1Department of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Freiburg, Germany, 2Department of Internal Medicine, Clinic for Rheumatology and Clincal Immunology, Freiburg, Germany, 3Department of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, 79106, Germany, 4Dpt. Rheumatology & Clinical Immunology and Centre for Chronic Immunodeficiency, University Hospital Freiburg, University Medical Center, University of Freiburg, Freiburg, Germany, 5Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland

    Background/Purpose:  B cells are pivotal to the pathogenesis of many autoimmune diseases including rheumatoid arthritis (RA). Tofacitinib, a JAK inhibitor, is effective and safe in…

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