ACR Meeting Abstracts

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Abstracts tagged "antibodies and interleukins (IL)"

  • Abstract Number: 2585 • 2018 ACR/ARHP Annual Meeting

    Secukinumab Immunogenicity in Patients with Psoriatic Arthritis and Ankylosing Spondylitis during a 52-Week Treatment Period

    Atul A. Deodhar1, Dafna D Gladman2, Iain B. McInnes3, Vibeke Strand4, Mengyuan Ren5, Sebastian Spindeldreher6, Luminita Pricop7, Brian Porter7, Jorge Safi7, Abhijit Shete8 and Gerard Bruin6, 1Oregon Health & Science University, Portland, OR, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 4Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, 5Novartis Pharmaceuticals, Shanghai, China, 6Novartis Institutes for BioMedical Research, Basel, Switzerland, 7Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ, 8Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland

    Background/Purpose: Secukinumab, a fully human monoclonal IgG1 antibody (mAb) that selectively targets IL-17A, is efficacious for the treatment of psoriasis, psoriatic arthritis (PsA) and ankylosing…
  • Abstract Number: 1291 • 2012 ACR/ARHP Annual Meeting

    A Phase Ib Clinical Trial with F8-IL10, an Anti-Inflammatory Immunocytokine for the Treatment of Rheumatoid Arthritis (RA), Used in Combination with Methotrexate (MTX)

    Mauro Galeazzi1, Caterina Baldi1, Elena Prisco2, Marco Bardelli1, Dario Neri3, Leonardo Giovannoni4, Enrico Selvi1 and Roberto Caporali2, 1Rheumatology, University of Siena, Siena, Italy, 2Rheumatology, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, 3Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland, 4Philogen S.p.A., Siena, Italy

    Background/Purpose: Interleukin 10 (IL10) is an anti-inflammatory cytokine potentially efficacious for RA. F8-IL10 is a fusion protein in which the cytokine is fused with the…
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ACR Pediatric Rheumatology Symposium 2020

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