ACR Meeting Abstracts

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Abstracts tagged "anti-TNF therapy"

  • Abstract Number: 2962 • 2017 ACR/ARHP Annual Meeting

    MRI Results Following Discontinuation of Methotrexate in Patients with Rheumatoid Arthritis Treated with Subcutaneous Tocilizumab: Results from a Randomized Controlled Trial

    Charles Peterfy1, Joel Kremer2, William F C Rigby3, Nora Singer4, Christine Birchwood5, Darcy Gill5, William Reiss5, Jinglan Pei5 and Margaret Michalska5, 1Spire Sciences, Inc., Boca Raton, FL, 2Albany Medical College, Albany, NY, 3Geisel School of Medicine at Dartmouth, Lebanon, NH, 4Case Western Reserve University School of Medicine, Cleveland, OH, 5Genentech, Inc., South San Francisco, CA

    Background/Purpose: Although previous studies have established the efficacy of tocilizumab (TCZ) initiated as monotherapy (MONO) for the treatment of rheumatoid arthritis (RA),1,2 changes in active…
  • Abstract Number: 546 • 2017 ACR/ARHP Annual Meeting

    Concomitant Hydroxychloroquine Impact on Anti-TNF Persistence in Patients with Rheumatoid Arthritis

    Ming Zhao1, Harlan Sayles2, James R. O'Dell1 and Kaleb Michaud2,3, 1Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Omaha, NE, 3National Data Bank for Rheumatic Diseases, Wichita, KS

    Background/Purpose: Tumor necrosis factor-α inhibitors (TNFi) have been widely used in patients who failed conventional DMARDs in the treatment of rheumatoid arthritis (RA). While most…
  • Abstract Number: 1543 • 2017 ACR/ARHP Annual Meeting

    Real-World Effectiveness of TNF Inhibition in Spondyloarthritis. Data from a Large Nationwide Prospective Cohort – the British Society for Rheumatology Biologics Register for Ankylosing Spondylitis

    Gareth T. Jones1, Andrew Keat2, Ejaz Pathan3 and Gary J. Macfarlane1, 1Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, 2Rheumatology., Northwick Park Hospital, London, United Kingdom, 3Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom

    Background/Purpose: TNF inhibition has revolutionised the treatment of axial spondyloarthritis (AxSpA). Much of what we know about the use of these drugs comes from randomised…
  • Abstract Number: 550 • 2017 ACR/ARHP Annual Meeting

    Long-Term Safety of Tocilizumab from Large Clinical Trial and Postmarketing Populations

    Shalini Mohan1, Margaret Michalska2, Jeffrey Yourish2, Jinglan Pei2, Sara Gale1, Christine Birchwood2 and Erhan Berber2, 1Genentech, South San Francisco, CA, 2Genentech, Inc., South San Francisco, CA

    Background/Purpose: Tocilizumab (TCZ) is a recombinant humanized monoclonal antibody targeted against the interleukin-6 receptor that was approved to treat rheumatoid arthritis (RA) in the EU…
  • Abstract Number: 1548 • 2017 ACR/ARHP Annual Meeting

    Opioid Use in Patients with Ankylosing Spondylitis

    Victor S. Sloan1, Anna Sheahan1, Jeffrey Stark2 and Robert Y. Suruki1, 1UCB Pharma, Raleigh, NC, 2UCB Pharma, Smyrna, GA

    Background/Purpose: The use or misuse of opioids has become a major public health issue in the USA. It is estimated that the economic burden of…
  • Abstract Number: 606 • 2017 ACR/ARHP Annual Meeting

    Secukinumab Demonstrates Consistent Safety over Long-Term Exposure in Patients with Psoriatic Arthritis and Moderate to Severe Plaque Psoriasis: Updated Pooled Safety Analyses

    Philip J Mease1, Iain B. McInnes2, Kristian Reich3, Peter Nash4, Mats Andersson5, Ken Abrams6, Luminita Pricop6 and Todd Fox5, 1Swedish Medical Center and University of Washington, Seattle, WA, 2University of Glasgow, Glasgow, United Kingdom, 3Dermatologikum Hamburg, Hamburg, Germany, 4University of Queensland, Brisbane, Australia, 5Novartis Pharma AG, Basel, Switzerland, 6Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: Pooled safety data from secukinumab psoriasis (PSO) and psoriatic arthritis (PsA) clinical trial programs after ~1 year of exposure have been reported previously.1, 2…
  • Abstract Number: 1554 • 2017 ACR/ARHP Annual Meeting

    Discontinuation and Switching Patterns By TNFi Line of Therapy in Patients with Psoriatic Arthritis—Results from the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry

    Philip J Mease1, Chitra Karki2, Mei Liu2, YouFu Li3, Peter Hur4 and Jeffrey D. Greenberg5, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Corrona, LLC, Southborough, MA, 3University of Massachusetts Medical School, Worcester, MA, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5New York University School of Medicine, New York, NY

    Background/Purpose: Few real-world studies have characterized the use of first- vs second-line tumor necrosis factor inhibitors (TNFis) in US patients with psoriatic arthritis (PsA). This…
  • Abstract Number: 630 • 2017 ACR/ARHP Annual Meeting

    Effects of Intravenous Golimumab, an Anti-Tnfα Monoclonal Antibody, on Mental and Physical Functioning and Health-Related Quality of Life in Active Psoriatic Arthritis: 24-Week Results of a Phase 3 Trial

    M. Elaine Husni1, Arthur Kavanaugh2, Eric K. H. Chan3, Nan Li4, Steven Peterson4, Elizabeth C. Hsia5, Lilianne Kim4, Kim Hung Lo4 and Diane D. Harrison4, 1Rheumatology, Cleveland Clinic, Cleveland, OH, 2Medicine, University of California, San Diego, La Jolla, CA, 3Janssen Global Services, LLC, Raritan, NJ, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA

    Background/Purpose: To evaluate physical and mental health functioning, health state, and health-related quality of life (HRQoL) in patients with active psoriatic arthritis (PsA) treated with…
  • Abstract Number: 1570 • 2017 ACR/ARHP Annual Meeting

    Monocytes from Male Patients with Ankylosing Spondylitis Display Decreased Osteoclastogenesis and Decreased RANKL/OPG Ratio

    Valéria F. Caparbo1, Carla G.S. Saad1, Julio C. B. Moraes2, Artur J de Brum-Fernandes3 and Rosa M R Pereira4, 1Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil, 3Rheumatology Division, Université de Sherbrooke, Rheumatology Division, Canada, Sherbrooke, QC, Canada, 4Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

    Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disease characterized by new bone growth that leads to syndesmophyte formation and subsequent vertebral ankyloses, although AS…
  • Abstract Number: 638 • 2017 ACR/ARHP Annual Meeting

    Are There Clinical Demographic or Subclinical Ultrasonographic Data That Can Predict Flare in Psoriatic Arthritis Patients during a Phase of Minimal Disease Activity after Spacing of Anti-TNF Blockers Injections?

    Pierluigi Macchioni1, Giovanni Ciancio2, Gilda Sandri3, Alen Zabotti4, Luca Montaguti5, Gentiana Vukatana6, Fabio Mascella7, Donatella Chessa8, Elisa Verduci9, Marcello Govoni10, Amelia Spinella3, Francesca Zuliani11, Marco Bruschi5, Nazzarena Malavolta12 and Mariacristina Focherini7, 1Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria Sant’Anna - Ferrara (Italy), ferrara, Italy, 3Rheumatology Unit, University fo Modena & Reggio, Modena, Italy, 4Rheumatology Clinic, Department of Medical and Biological Sciences, Santa Maria della Misericordia" University Hospital, Udine, Italy, 5Dipartimento Internistico SS di Reumatologia, AUSL Romagna Ospedale Bufalini, Cesena, Italy, 6Rheumatology Unit, Department CardioThoracic Vascular, S.Orsola- Malpighi Hospital, Alma Mater Studiorum, Bologna, Bologna, Italy, 7Internal Medicine and Rheumatology, Ospedale Infermi Rimini, Rimini, Italy, 8Internal Medicine, Ospedale Paolo Dettori, Tempio Pausania, Italy, 9Rheumatology Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy, 10Rheumatology Clinic, Department of Medical and Biological Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria Sant’Anna - Ferrara (Italy), ferrara, Italy, 11Rheumatology Unit, Department of Medical Sciences, Santa Maria della Misericordia" University Hospital, Udine, Italy, 12Policlinico S.Orsola-Malpighi, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy

    Background/Purpose: Tumour necrosis factor (TNF)-blocker tapering has been proposed for patients with psoriatic arthritis (PA) in clinical remission. To evaluate if there are clinical, demographic…
  • Abstract Number: 1825 • 2017 ACR/ARHP Annual Meeting

    Comparative Analysis of Achievement of Individual Important Response Measured By DAS28dcrit in a Randomized Head-to-Head Trial of Tocilizumab Vs. Adalimumab in Active Rheumatoid Arthritis

    Michaela Koehm1, Michael Hofmann2, Rasmus Lüthje2, Matthew McIntosh3, Varghese Abraham3, Cem Gabay4, Arthur Kavanaugh5, Harald Burkhardt6 and Frank Behrens6, 1Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt/Main, Germany, 2Rheumatology, Chugai Pharma Europe Ltd., Frankfurt, Germany, 3Genentech, San Francisco, CA, 4SCQM, Geneva, Switzerland, Geneva, Switzerland, 5Medicine, University of California, San Diego, La Jolla, CA, 6Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany

    Background/Purpose: Fluctuations in disease activity due to short-term situational effects and measurement errors are important considerations for evaluation of individual clinically meaningful therapeutic response in…
  • Abstract Number: 1019 • 2017 ACR/ARHP Annual Meeting

    Molecular Profiling of RA Patients Suggests a Differential Involvement of Adaptive and Innate Cell Populations in Response to Anti-TNF Treatment

    Victor Farutin1, Thomas Prod'homme1, Kevin McConnell1, Nathaniel Washburn1, Patrick Halvey1, Jamey Guess1, Nur Sibel Gunay1, Jan Hillson2, Carol J. Etzel3, Katherine C. Saunders3, Dimitrios A. Pappas3,4, Anthony Manning1, Leona Ling1 and Ishan Capila1, 1Research, Momenta Pharmaceuticals, Inc., Cambridge, MA, 2Clinical Research, Momenta Pharmaceuticals, Inc., Cambridge, MA, 3Corrona, LLC, Southborough, MA, 4Columbia University, New York, NY

    Background/Purpose: Despite the success of anti-TNF therapies in RA, ~ 30 % of patients are non-responders. Several studies have focused on understanding the biology underlying…
  • Abstract Number: 1905 • 2017 ACR/ARHP Annual Meeting

    Sustained Response Following Discontinuation of Methotrexate in Patients with Rheumatoid Arthritis Treated with Subcutaneous Tocilizumab: Results from a Randomized Controlled Trial

    Joel Kremer1, William F C Rigby2, Nora Singer3, Christine Birchwood4, Darcy Gill4, William Reiss4, Jinglan Pei4 and Margaret Michalska4, 1Albany Medical College, Albany, NY, 2Geisel School of Medicine at Dartmouth, Lebanon, NH, 3Case Western Reserve University School of Medicine, Cleveland, OH, 4Genentech, Inc., South San Francisco, CA

    Background/Purpose: Although methotrexate (MTX) is often administered in combination with biologics for the treatment of rheumatoid arthritis (RA), it may be discontinued due to intolerance…
  • Abstract Number: 1049 • 2017 ACR/ARHP Annual Meeting

    Heart Rate Variability Testing with Autonomic Nervous System Optimization: Could It Change the Course of Spending for Rheumatoid Arthritis Patients in the U.S.? an Exploratory Minimal Model Analysis

    Marita Zimmermann1, Elisabeth Vodicka2, Andrew J Holman3,4,5 and Louis P Garrison2, 1Constants in Global Health, University of Washington, Seattle, WA, 2Consultants in Global Health, University of Washington, Seattle, WA, 3Rheumatology, Pacific Rheumatology Associates Inc PS, Seattle, WA, 4Inmedix, Normandy Park, WA, 5Pacific Rheumatology Reseach, Seattle, WA

    Background/Purpose: Autonomic nervous system (ANS) testing with heart rate variability (HRV) has been shown to predict 52-week anti-TNF therapeutic outcomes in rheumatoid arthritis (RA).1 HRV…
  • Abstract Number: 2449 • 2017 ACR/ARHP Annual Meeting

    Comparative Effectiveness of Tocilizumab (TCZ) Monotherapy with Tumor Necrosis Factor Inhibitors (TNFi) in Combination with Varying Doses of Methotrexate (MTX) in Patients with Rheumatoid Arthritis

    Leslie R Harrold1, George W. Reed1, Jennie Best2, Steve Zlotnick2, Gioia Persuitte3 and Joel Kremer4, 1University of Massachusetts Medical School, Worcester, MA, 2Genentech, Inc., South San Francisco, CA, 3Corrona, LLC, Southborough, MA, 4Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Clinical studies have shown that the efficacy of TCZ monotherapy (TCZ mono) is superior to that of TNFi monotherapy and comparable to that of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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