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Abstracts tagged "Anti-TNF therapy and rheumatoid arthritis (RA)"

  • Abstract Number: 1118 • 2019 ACR/ARP Annual Meeting

    US Community Rheumatologists’ Knowledge and Perceptions of Biosimilar Expanded Indication Approval by Extrapolation

    Ting-Chun Yeh1, Yolaine Jeune-Smith 1, Eli Phillips 1, Ajeet Gajra 1 and Bruce Feinberg 1, 1Cardinal Health Specialty Solutions, Dublin, OH

    Background/Purpose: To expand treatment options, increase access to life-saving medications, and lower healthcare costs through competition, the US Congress created an abbreviated licensure pathway for…
  • Abstract Number: 1450 • 2017 ACR/ARHP Annual Meeting

    Influence of Immunogenicity to the First Anti-TNF Therapy on Response to the Second Biologic Agent in RA Patients

    Patricia Bogas1, Chamaida Plasencia-Rodriguez1, Alejandro Balsa1, Dora Pascual-Salcedo2, Gema Bonilla1, Enrique Moral Coro1, Carolina Tornero1, Laura Nuño1, Diana Peiteado3, Ana Martínez4 and Borja Hernández1, 1Hospital Universitario La Paz, Madrid, Spain, 2Immuno-Rheumatology Research group, La Paz University Hospital, Madrid, Spain, 3Rheumatology, La Paz University Hospital, Madrid, Spain, 4Immuno-Rheumatology research group, La Paz University Hospital, MADRID, Spain

    Background/Purpose: There is currently no consensus on selecting a therapeutic target in patients (pts) non-responsive to their first TNF inhibitors (TNFi). The development of anti-drug…
  • Abstract Number: 2477 • 2017 ACR/ARHP Annual Meeting

    Descriptive Patterns of Switches and Swaps in Patients with Rheumatoid Arthritis Initially Treated with Anti-TNF Agents in First Intention between 2000 and 2006, and 2007 and 2015 – Experience from a Real-World Database RHUMADATA®

    Denis Choquette1, Louis Bessette2, L Coupal3 and Kirsten Garces4, 1University of Montreal Hospital Research Centre (CRCHUM), Notre Dame Hospital Montreal, Montreal, QC, Canada, 2Groupe de Recherche en Rhumatologie et Maladies Osseuses, Quebec, Quebec, QC, Canada, 3Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 4Amgen Canada Inc., Mississauga, ON, Canada

    Background/Purpose: Between 2000 and 2006, the only other treatment option for patients with rheumatoid arthritis (RA) first exposed to an anti-TNF agent was another anti-TNF…
  • Abstract Number: 2478 • 2017 ACR/ARHP Annual Meeting

    Retention on Adalimumab, Etanercept, Golimumab and Infliximab in Two Eras – Experience of Patients with Rheumatoid Arthritis from a Real-World Database RHUMADATA®

    Denis Choquette1, Louis Bessette2, Louis Coupal3 and Kirsten Garces4, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 2Groupe de Recherche en Rhumatologie et Maladies Osseuses, Quebec, Quebec, QC, Canada, 3Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 4Amgen Canada Inc., Mississauga, ON, Canada

    Background/Purpose: Anti-TNFs have been used to treat RA since 2000. Since the availability of new agents with different mechanisms of action around 2007, the pattern…
  • Abstract Number: 2487 • 2017 ACR/ARHP Annual Meeting

    Comparison the Long-Term Clinical Outcomes between Non Anti-TNF Versus Anti-TNF in RA Patients Who Failed to a First Anti-TNF

    Patricia Bogas1, Chamaida Plasencia-Rodriguez1, Alejandro Balsa1, Victoria Navarro-Compán2, Gema Bonilla1, Enrique Moral Coro1, Carolina Tornero1, Laura Nuño1 and Diana Peiteado3, 1Hospital Universitario La Paz, Madrid, Spain, 2Rheumatology, Hospital Universitario La Paz, Madrid, Spain, 3Rheumatology, La Paz University Hospital, Madrid, Spain

    Background/Purpose: There are many biological therapies for Rheumatoid Arthritis (RA) with different mechanisms of action and good efficacy rate; however, up to 40% of patients…
  • Abstract Number: 2488 • 2017 ACR/ARHP Annual Meeting

    Golimumab Retention Rate in Patients with Rheumatoid Arthritis. Predictors of Long-Term Retention

    Belen Serrano1, Carlos M Gonzalez2, Roberto González3, Julia Martínez-Barrio4, Juan Gabriel Ovalles-Bonilla5, Juan Carlos Nieto2, Iustina Janta2, Larissa Valor3, Francisco Javier López Longo6 and Indalecio Monteagudo2, 1Rheumatology, Hospital General Universitario Gregorio Marañón, Genoa, Italy, 2Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 3Rheumatology, Hospital general Universitario Gregorio Marañón, Madrid, Spain, 4Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 5Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, 6Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain

    Background/Purpose: The efficacy of Golimumab (GLM) treatment in rheumatoid arthritis (RA) has been widely documented. The aim of this study was to analize the long-term…
  • Abstract Number: 533 • 2016 ACR/ARHP Annual Meeting

    What Proportion of Patients Fail to Achieve CDAI and SDAI Remission Based on Physician Global Assessment? an Analysis from the Prospective, Observational Registry

    Michael Starr1, Boulos Haraoui2, Denis Choquette3, Louis Bessette4, Andrew Chow5, Philip Baer6, Suneil Kapur7, John Kelsall8, Michelle Teo9, Emmanouil Rampakakis10, Eliofotisti Psaradellis11, Francois Nantel12, Allen J Lehman13, Brendan Osborne14, Karina Maslova13 and Cathy Tkaczyk14, 1Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, 2University of Montreal, Montreal, QC, Canada, 3Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 4Rheumatology, CHUL de Quebec, Quebec, QC, Canada, 5Credit Valley Rheumatology, Mississauga, ON, Canada, 6Independent Rheumatology Practice, Scarborough, ON, Canada, 7University of Ottawa, 139 Greenbank Rd, Suite 203, ON, Canada, 8Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, 9Balfour Medical Clinic, Penticton, BC, Canada, 10JSS Medical Research, St-Laurent, QC, Canada, 11JSS Medical Research, Montreal, QC, Canada, 1219 Green belt Dr, Janssen Inc., Toronto, ON, Canada, 13Janssen Inc., Toronto, ON, Canada, 14Medical Affairs, Janssen Inc., Toronto, ON, Canada

    Background/Purpose: Physician’s Global Assessment of Disease Activity (MDGA) is a measure that is frequently incorporated in disease activity indices which reflects the physician’s perception of…
  • Abstract Number: 612 • 2016 ACR/ARHP Annual Meeting

    Long-Term Sustainability of TNF-Blocker Injection Spacing in Rheumatoid Arthritis: Results of a 3-Year Long-Term Observational Follow-up of a Tapering randomised Controlled Trial

    Johanna Sigaux1, Florian Bailly2,3, Frédérique Gandjbakhch1,3, Violaine Foltz1,3, Florence Tubach4,5, Laure Gossec1,6 and Bruno Fautrel1,7, 1Rheumatology, Pitié Salpêtrière Hospital, Paris, France, 2rheumatology, Pitié Salpêtrière Hospital, paris, France, 3Sorbonne Universités, UPMC Univ Paris 06, Paris, France, Paris, France, 4Aix-Marseille University, Marseille, France, 5Université Pierre et Marie Curie (UPMC)-Paris 6; APHP, Pitié Salpêtrière Hospital, Département Biostatistics and Public health, Pharmacoepidémiology center (Cephepi), 7501875013, Paris, France ;, Paris, France, 6Sorbonne Universités, UPMC University Paris 06, Paris, France, Paris, France, 7GRC08, Sorbonne Universités, UPMC Univ Paris 06, Paris, France, Paris, France

    Background/Purpose: Tapering of TNF blockers (TNFb) in rheumatoid arthritis (RA) patients in sustained remission is feasible in short-term randomized controlled trials (RCT). Less data are…
  • Abstract Number: 625 • 2016 ACR/ARHP Annual Meeting

    Efficacy and Safety of Intravenous Golimumab Plus Methotrexate in Patients 65 Years and Younger and Those Greater Than 65 Years of Age-a Post-Hoc Analysis

    John Tesser1, Shelly Kafka2, Raphael J. DeHoratius3, Stephen Xu4, Kehzen L. Tang4, Elizabeth C. Hsia5 and Anthony Turkiewicz6, 1Arizona Arthritis & Rheumatology Associates, Glendale, AZ, 2Janssen Scientific Affairs, LLC, Horsham, PA, 3Janssen Scientific Affairs, LLC/Sidney Kimmel School of Medicine, Thomas Jefferson University, Horsham/Philadelphia, PA, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA, 6Rheumatology Associates, Birmingham, AL

    Background/Purpose: There is a paucity of data on the use of anti-TNF therapy in patients >65 years. In this sub-analysis of GO-FURTHER, we compare the…
  • Abstract Number: 1043 • 2016 ACR/ARHP Annual Meeting

    Safety and Efficacy of Intravenous Golimumab in Adult Patients with Active Ankylosing Spondylitis: Results through Week 28

    Atul A. Deodhar1, John D. Reveille2, Diane D. Harrison3, Lilianne Kim4, Kim Hung Lo4 and Elizabeth C. Hsia5,6, 1Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, 2Rheumatology, University of Texas-McGovern Medical School, Houston, TX, 3Janssen Research & Development, LLC., Horsham, PA, 4Janssen Research & Development, LLC., Spring House, PA, 5Janssen Research & Development, LLC, Spring House, PA, 6University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Subcutaneous (SC) golimumab (GLM) is currently approved for adult patients (pts) with RA, PsA, and AS. The GO-ALIVE study was designed to evaluate the…
  • Abstract Number: 1453 • 2016 ACR/ARHP Annual Meeting

    Treatment of BAFF Transgenic Mice with Anti-TNF: Monoclonals Are Associated with a Higher Risk of Lymphoma Than Etanercept

    Gaetane Nocturne1,2, Bineta Ly3, Saida Boudaoud4, raphaèle seror5,6, Carole Nicco7, Christiane Chereau7, Niloufar Kavian7,8, Frederic Batteux7,8, Fabienne Mackay9, Fabien Vincent9, Thierry Lazure10, Sophie Ferlicot10, Lev Stimmer11, Roman Krzysiek10, Salima Hacein-Bey10 and Xavier Mariette12,13, 1Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, 2INSERM U1184, Université Paris Sud, Le Kremlin Bicêtre, France, 3INSERM U1184, Paris Sud University, Kremlin Bicetre, France, 4INSERM U1184, Paris Sud University, Le Kremlin Bicêtre, France, 5Assistance Publique-Hôpitaux de Paris (APHP), Hôpitaux universitaires Paris Sud, Université Paris Sud, kremlin bicetre, France, 6INSERM U1184, Paris Sud University, Le Kremlin Bicetre, France, 7Institut Cochin, Paris, France, 8Immunology, APHP Hopital Cochin, Paris, France, 9Monash university, Melbourne, Australia, 10APHP Hopitaux universitaires Paris sud, Le Kremlin Bicetre, France, 11CEA - MIRCen, Fontenay aux Roses, France, 12Department of Rheumatology, APHP - Hopitaux universitaire Paris Sud, Le Kremlin Bicetre, France, 13INSERM U1184, Université Paris-Sud, Paris, France, Le Kremlin Bicetre, France

    Background/Purpose: Patients suffering from rheumatoid arthritis (RA) have an increased risk of lymphoma and disease activity is the main risk factor. The impact of treatment,…
  • Abstract Number: 2493 • 2016 ACR/ARHP Annual Meeting

    Patient Characteristics and Medication Utilization Patterns of Infliximab-Treated Rheumatoid Arthritis Patients Subsequently Transitioned to Intravenous Golimumab

    Lorie A. Ellis1, Raphael J. DeHoratius2, Shelly Kafka3, Helen Varker4, Matthew Brouillette4 and Elisabetta Malangone-Monaco4, 1Health Economics & Outcomes Research, Janssen Scientific Affairs, LLC, Horsham, PA, 2Janssen Scientific Affairs, LLC/Sidney Kimmel School of Medicine, Thomas Jefferson University, Horsham/Philadelphia, PA, 3Janssen Scientific Affairs, LLC, Horsham, PA, 4Truven Health Analytics, Bethesda, MD

    Background/Purpose:  Infliximab (IFX) and golimumab (GLM-IV) for intravenous use are anti-TNF agents indicated for rheumatoid arthritis (RA) and differ in weight-based dose, induction schedule, and…
  • Abstract Number: 2638 • 2016 ACR/ARHP Annual Meeting

    In Vitro Expansion of Treg By Adaimumab Predicts Clinical Response to Therapy in Patients with Rheumatoid Arthritis

    Dao Xuan Nguyen, Centre of Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Regulatory T cells (Treg) are potent suppressors of immune responses and are considered a pivotal element in resolving inflammation and autoimmunity. We have previously…
  • Abstract Number: 2780 • 2015 ACR/ARHP Annual Meeting

    Relationship Between Immunogenicity, Hypersensitivity Reactions and Skin Tests Against Infliximab, Etanercept and Adalimumab in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Firas Doghanji1, Sebnem Ataman2, Ali Erhan Ozdemirel2, Recep Bülent Seckin1, Ayse Peyman Yalcin1 and Sevim Bavbek3, 1Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, 2Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, 3Immunology and Allergy, Ankara University Faculty of Medicine, Ankara, Turkey

    Relationship between immunogenicity, hypersensitivity reactions and skin tests against Infliximab, Etanercept and Adalimumab in patients with rheumatoid arthritis and ankylosing spondylitis Background/Purpose: Anti-TNF drugs can…
  • Abstract Number: 106 • 2015 ACR/ARHP Annual Meeting

    Does the Timing of Phenotype Assessment Influence Association Results in Pharmacogenetics Studies of Anti-TNF Response in Rheumatoid Arthritis?

    Kyoko Honne1, Nicholas Jewell2, Takeo Sakurai3, Masahiro Iwamoto4, Seiji Minota4 and Damini Jawaheer5, 1Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 2UC Berkeley, Berkeley, CA, 3Inoue Hospital, Takasaki, Japan, 4Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 5Children's Hospital Oakland Research Institute, Oakland, CA

    Background/Purpose:  Pharmacogenetics studies of anti-tumor necrosis factor (TNF) response among patients with rheumatoid arthritis (RA) have routinely used assessment of response at a single time-point,…
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