Abstracts tagged "Anti-TNF therapy and monocytes"

Abstract Number: 1847 • 2013 ACR/ARHP Annual Meeting
Certolizumab-Pegol Induces Reverse Signaling Through Membrane TNF Via Calcineurin Activation In Human Monocytes. Relevance In Inflammation
Jean-Frederic Boyer^1,2, Michel Baron³, Delphine Nigon¹, Arnaud L. Constantin¹, Alain G. Cantagrel^1,2 and Jean-Luc Davignon^2,4, ¹Rheumatology, Purpan University Hospital, Toulouse Cedex 9, France, ²INSERM CNRS UMR 1043, Paul Sabatier University Toulouse, Toulouse, France, ³Centre de Physiopathologie de Toulouse Purpan, INSERM CNRS UMR 1043, Paul Sabatier University Toulouse, Toulouse, France, ⁴Rheumatology, Purpan University Hospital, Toulouse, France
Background/Purpose: Reverse signalling seems to play a role in the mode of action of anti-TNF-α agents but this pathway and its relevance are poorly understood.…

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Abstracts tagged "Anti-TNF therapy and monocytes"

Certolizumab-Pegol Induces Reverse Signaling Through Membrane TNF Via Calcineurin Activation In Human Monocytes. Relevance In Inflammation