Abstracts tagged "Anti-GBM Disease (Goodpasture’s)"

Abstract Number: 2130 • ACR Convergence 2026
Analytical Evaluation of a Fully Automated Multiplexed Microarray Immunoassay for Detection of Anti-PR3, Anti-MPO, and Anti-GBM Autoantibodies Compared with Routine Immunoassays in Two Clinical Laboratories in the Netherlands
Renske J.E. van den Bijgaart¹, Puck A. Westerhof¹, Lisanne S. Wetzels², Inana Namet³, Gerber Gomez⁴, Stephan Kamphuis¹, Jeroen D.E. van Suijlen¹ and Brigitte A. Wevers² Affiliations: ¹Laboratory of Clinical Chemistry and Hematology, Clinical Diagnostics Gelre, Apeldoorn, Netherlands, ²Division of Laboratories, Pharmacy and Biomedical Genetics, Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, Netherlands, ³Product Management, AliveDx Suisse SA, Eysins, Switzerland, ⁴Scientific and Medical Affairs, AliveDx Suisse SA, Eysins, Vaud, Switzerland
Background/Purpose: Autoantibody testing is central to diagnosing glomerular basement membrane (GBM) disease and ANCA-associated vasculitides (AAV). Key markers include IgG autoantibodies to myeloperoxidase (MPO), proteinase…
Abstract Number: 2136 • ACR Convergence 2026
Graded, MPO/p-ANCA-selective co-activation of cell-bound complement and T-cell autoantibodies with ANCA intensity
Rodney Daniel¹, Tyler O'Malley², Brittany Partain², Haleh Ashki², Cynthia Alvarez², Christine Schleif², Tyler Alexander² and Michael Mahler³ Affiliations: ¹Illumination Health, Boca Raton, FL, ²Exagen, Carlsbad, CA, ³Exagen Inc., San Diego, CA
Background/Purpose: Cell-bound complement activation products (CB-CAPs: erythrocyte-bound C4d [EC4d], B-cell-bound C4d [BC4d]) and newer T-cell-directed markers (T-cell-bound C4d [TC4d], anti-T-cell IgG/IgM [TIgG/TIgM]) index complement, T-cell…
Abstract Number: 0711 • ACR Convergence 2025
Analytical Performance of a Novel, Fully Automated Multiplexed Microarray Immunoassay Prototype for the Simultaneous Detection of Autoantibodies to GBM, PR3, and MPO: A Multicenter Evaluation
Natalia Swierczynska¹, Ruaridh Armour¹, Anthony Yau¹, Enn Rusi¹, Mark Hooper¹, Jason Sillitoe², Caroline Wilson², Paula Griffiths³, Tariq El-Shanawany³, Faye Sims⁴, Gerber Gomez⁵, Christian Fischer⁵, Michael Hausmann⁶ and Helen Laird¹, ¹Research & Development, AliveDx, Edinburgh, Scotland, United Kingdom, ²North East Innovation Lab, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England, United Kingdom, ³Immunology Department, Laboratory Medicine, Swansea Bay University Health Board, UK. Cardiff and Vale UHB, Swansea, Wales, United Kingdom, ⁴Clinical Biochemistry and Immunology Department Peterborough City Hospital, North West Anglia NHS Foundation Trust, Peterborough, England, United Kingdom, ⁵Scientific & Medical Affairs, AliveDx Suisse SA, Eysins, Switzerland, ⁶AliveDx Suisse SA, Eysins, Switzerland
Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCA), including those directed to myeloperoxidase (MPO) and proteinase 3 (PR3) as well as antibodies against anti-glomerular basement membrane (anti-GBM) are…
Abstract Number: 2496 • ACR Convergence 2023
HXB-319, a New Generation Mesenchymal Stromal Cell (MSC) Therapy, Alleviates Neutrophilic Inflammation, and End-organ Damage in Pulmonary Renal Syndromes by Inducing FoxP3+ Tregs, and by Promoting TNFα-stimulated gene-6 (TSG-6) over Expression
Hulya Bukulmez¹, Adrienne Dennis¹, Jane Reese-Koc², Scott Sieg² and Steven Emancipator², ¹MetroHealth Medical Center, Department of Pediatrics, Cleveland, OH, ²Case Western Reserve University, Cleveland, OH
Background/Purpose: Mesenchymal stromal cells (MSCs) have been shown to be safe therapies in more than 100 human clinical trials. However, MSCs clinical efficacy is variable,…
Abstract Number: 1574 • ACR Convergence 2022
Vasculitides as Medication-Associated Adverse Events Based on a National Database Reporting System
Alicia Rodriguez-Pla, Mayo Clinic Arizona, Scottsdale, AZ
Background/Purpose: Vasculitides have been reported as adverse events (AEs) related to a wide variety of medications. We aimed to analyze the vasculitides reported to a…