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Abstracts tagged "anti-dsDNA and glomerulonephritis"

  • Abstract Number: 2563 • ACR/ARHP Annual Meeting 2017

    SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice

    Akiko Nagasu1, Tomoyuki Mukai1, Masanori Iseki2, Hajime Nagasu3, Shunichi Fujita1, Takafumi Mito1, Shoko Kodama1, Yumi Sasae4, Naoki Kashihara3, Katsuhiko Ishihara2, Yasuyoshi Ueki5 and Yoshitaka Morita1, 1Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, 2Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, 3Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan, 4Department of Rheumatology, Kawasaki Medical School, Kurashiki Okayama, Japan, 5Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, leading to multiple organ dysfunction. SH3BP2 (Src homology domain 3…

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