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Abstracts tagged "Anti-drug antibodies"

  • Abstract Number: 1525 • ACR Convergence 2021

    Risk Factors for Anti-infliximab Antibody Formation: Results from a Randomized Controlled Trial

    Marthe Brun1, Guro Goll1, Kristin Jørgensen2, Joseph Sexton1, Johanna Gehin3, Øystein Sandanger4, Inge Olsen4, Rolf Anton Klaasen4, David Warren4, Cato Mørk5, Tore Kvien1, Jørgen Jahnsen2, Nils Bolstad4, Espen Haavardsholm1 and Silje Watterdal Syversen1, 1Diakonhjemmet Hospital, Oslo, Norway, 2Akershus University Hospital, Lørenskog, Norway, 3Oslo University Hospital, Lillehammer, Nepal, 4Oslo University Hospital, Oslo, Norway, 5Akershus Dermatology Center, Lørenskog, Norway

    Background/Purpose: Immunogenicity is related to loss of efficacy and safety to TNFα inhibitors and is frequently observed early in the treatment course. The highest rate…
  • Abstract Number: 586 • 2019 ACR/ARP Annual Meeting

    Drug Concentrations and Anti-drug Antibodies Influence in Response to Adalimumab: Results from the BioEfficacySpA Clinical Trial

    José Marona1, Santiago Rodrigues-Manica 2, João Lagoas Gomes 1, Carina Lopes 3, Inês Iria 4, Miguel Bernardes 5, Helena Santos 6, Jose Tavares-Costa 7, João Madruga-Dias 8, Patrícia Pinto 9, Alexandra Bernardo 10, Sara Maia 11, Jaime Branco 2, João Gonçalves 4 and Fernando Pimentel-Santos 2, 1Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon., Lisbon, Portugal, 2CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, 3Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal, 4Faculdade de Farmácia da Universidade de Lisboa; Portugal, Lisbon, Portugal, 5Rheumatology, Centro Hospitalar de São João, Porto, Portugal, Porto, Portugal, 6Instituto Português de Reumatologia (IPR), Lisbon, Portugal, 7ULSAM, Ponte de Lima, Portugal, Ponte de Lima, Portugal, 8CHMT, Torres Novas, Portugal, Torres Novas, 9Rheumatology Department, CHVNG, Vila Nova de Gaia, Portugal, 10Rheumatology Department, CHSJ, Porto, Portugal, 11CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal

    Background/Purpose: Almost all protein-based biotherapeutics can induce immunogenicity, which may result in loss of efficacy and/or increased risk of adverse reactions. Despite all the efforts…
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ACR Pediatric Rheumatology Symposium 2020

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