Abstracts tagged "anti-DNA and lupus nephritis"

Abstract Number: 1916 • 2019 ACR/ARP Annual Meeting
Reduced DNASE1L3 Activity in Sporadic SLE Is Linked to Increased DNA Load of Microparticles, Reactivity to DNASE1L3-sensitive Antigens, and Lupus Nephritis
Johannes Hartl¹, Robert Clancy ¹, Peter Izmirly ¹, H Michael Belmont ², Catherine Trad ¹, Nicole Bornkamp ¹, Vanja Sisirak ¹, Benjamin Sally ¹, Jill Buyon ¹ and Boris Reizis ¹, ¹NYU School of Medicine, New York, ²NYU Langone Health, New York, NY
Background/Purpose: Null mutations in DNASE1L3 cause severe familial SLE with prominent anti-DNA antibodies (Abs), suggesting that DNASE1L3 is a key driver of tolerance to DNA.…

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Abstracts tagged "anti-DNA and lupus nephritis"

Reduced DNASE1L3 Activity in Sporadic SLE Is Linked to Increased DNA Load of Microparticles, Reactivity to DNASE1L3-sensitive Antigens, and Lupus Nephritis