Abstracts tagged "anti-citrullinated protein/peptide antibodies (ACPA) and therapeutic targeting"

Abstract Number: 293 • 2017 ACR/ARHP Annual Meeting
Expanded Therapeutic ACPA Utility for Different NET-Driven Human (Autoimmune) Diseases
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Kostantinos Kambas³, Gonny Schmets¹, Hans Kalisvaart¹, Galina S. Bogatkevich⁴, Tim Shaw², Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands, ³Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant Neutrophil Extracellular Trap (NET) formation contributes to the induction and propagation of inflammation and plays a key role in causing tissue damage in…
Abstract Number: 205 • 2015 ACR/ARHP Annual Meeting
Mode of Action of Therapeutic Anti-Citrullinated Protein Antibodies Revealed: Inflammation Reduction Due to Inhibition of Netosis
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Gonny Schmets¹, Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands
Background/Purpose: Neutrophils together with aberrant Neutrophil Extracellular Trap (NET) formation contribute to the induction and propagation of inflammation. A growing number of studies indicate that…

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