Abstracts tagged "Annexins"

Abstract Number: 2719 • 2017 ACR/ARHP Annual Meeting
Can Annexin A1 Expression on Neutrophils Distinguish Adult IgA Vasculitis from Other Small Vessel Vasculitides?
Tadeja Kuret¹, Katja Lakota^1,2, Polona Žigon¹, Manca Ogrič¹, Boris Lestan¹, Snezna Sodin Semrl^1,2, Saša Čučnik^1,3, Matija Tomšič^1,4 and Alojzija Hočevar¹, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia, ³Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, ⁴University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
Background/Purpose: Immunoglobulin A vasculitis (IgAV, formerly Henoch–Schönlein purpura) is a small vessel, immune complex vasculitis characterized by dominant IgA deposits in the vascular wall. Clinical…
Abstract Number: 1103 • 2015 ACR/ARHP Annual Meeting
Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion By Human Regulatory B Cells
Charlotte Hua¹, Rachel Audo², Michael Hahne², Bernard Combe³, Jacques Morel³ and Claire I. Daien³, ¹Department of Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ²IGMM-CNRS UMR5535, Montpellier, France, ³Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: B cells can have a negative regulatory role, mainly mediated by interleukin 10 (IL-10) and we recently showed that IL-10 producing B cells (B10…
Abstract Number: 1732 • 2012 ACR/ARHP Annual Meeting
Annexin A5 Resistance Identifies a Subset of Thrombosis Patients in Systemic Lupus Erythematosus
Ehtisham Akhter¹, Hong Fang², Xiao Xuan Wu³, Jacob Rand⁴ and Michelle Petri², ¹Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Pathology; Hematology Laboratories, Montefiore Medical Center, Bronx, NY, ⁴Montefiore Medical Center, Bronx, NY
Background/Purpose: Annexins are a family of structurally related proteins that bind to phospholipids in a calcium dependant manner. Annexin A5 (AnxA5), present on the surfaces…
Abstract Number: 1733 • 2012 ACR/ARHP Annual Meeting
Effect of Hydroxychloroquine (HCQ) On the Annexin A5 Resistance Assay (AnxA5-RA) in Antiphospholipid Antibody (aPL)-Positive Patients: Preliminary Results of an Ongoing Prospective Study
Alana B. Levine¹, Jacob H. Rand², Xiao Xuan Wu³, JoAnn Vega⁴, Glendalee Ramon¹, Stephen L. Lyman⁴, Doruk Erkan¹ and Michael D. Lockshin⁵, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Department of Pathology; Hematology Laboratories, Montefiore Medical Center, Bronx, NY, ³Pathology; Hematology Laboratories, Montefiore Medical Center, Bronx, NY, ⁴Research, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: One proposed mechanism of aPL-mediated thrombosis is disruption of the AnxA5 shield, allowing initiation of coagulation reactions on phospholipid surfaces. The AnxA5-RA measures the…

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