Abstracts tagged "Ankylosing spondylitis (AS) and spondylarthropathy"

Abstract Number: 645 • ACR/ARHP Annual Meeting 2017
An Oral Tyk2 Inhibitor Effectively Suppresses the Development of Murine Th17 Cells In Vivo and Prevents Joint Damage in Experimental Ankylosing Spondylitis
Eric Gracey^1,2, Melissa Lim², Zoya Qaiyum¹, Yuriy Baglaenko^1,2, Wenyan Miao³, Craig Masse³, William Westlin³ and Robert D Inman^1,4, ¹Department of Immunology, University of Toronto, Toronto, ON, Canada, ²Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ³Nimbus Therapeutics, Cambridge, MA, ⁴Toronto Western Hospital, University Health Network, toronto, ON, Canada
Background/Purpose: Th17 cells play an important role in the pathogenesis of ankylosing spondylitis (AS). Tyk2, a member of the Janus Kinase (JAK) family of signaling…
Abstract Number: 2822 • ACR/ARHP Annual Meeting 2015
Increased Peripheral Blood CCR6+/IL-23R+ Gamma Delta T Cells Are Associated with High Disease Activity in Patients with Axial Spondyloarthritis
Elizabeth Mainolfi¹, Susan M. Goodman², Shawn Anderson³, Jon Hill⁴, Thakker Paresh⁵, Meera Ramanujam⁶, Rivka Friedlander⁷, Elli Kim⁷, Dalit Ashany⁸, Ed Purdue⁹, Christine Averill⁹, Michael Nevid⁹, Allison Shaber⁹, Lisa Mandl¹⁰, Steven R. Goldring¹¹, Gerald Nabozny¹ and VP Bykerk², ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Transl. Medicine & Clin. Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Department of Medicine, Rheumatology Division, Hospital for Special Surgery, New York, NY, ⁸Rheumatic Disease, Hospital for Special Surgery, New York, NY, ⁹Osteolysis Research Laboratory, Hospital for Special Surgery, New York, NY, ¹⁰Department of Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Hospital for Special Surgery, New York, NY
Background/Purpose: The IL-23 axis and Th17 type immunity has been implicated in the pathogenesis of Ankylosing Spondylitis (AS) and an enrichment of gamma delta (gd)…
Abstract Number: 2457 • ACR/ARHP Annual Meeting 2013
Ankylosing Spondylitis and a Diagnostic Dilemma: Coccydynia
Rabia Deniz¹, Gülsen Ozen², Sibel Yilmaz-Oner², Sibel Z. Aydin³, Can Erzik⁴, Osman Hakan Gunduz⁵, Nevsun Inanc⁶, Haner Direskeneli² and Pamir Atagunduz⁶, ¹Marmara University School of Medicine, Istanbul, Turkey, ²Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ³Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, ⁴Medical Biology, Marmara University School of Medicine, Istanbul, Turkey, ⁵Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey, ⁶Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey
Background/Purpose: Coccydynia is defined as pain in or around the tail bone area. The most common cause of coccydynia is either a trauma such as…
Abstract Number: 1551 • ACR/ARHP Annual Meeting 2013
The Minimum Clinically Important Improvement and Patient Acceptable Symptom State In Basdai and BASFI For Patients With Ankylosing Spondylitis
Milla Kviatkovsky¹, Sofia Ramiro², Robert Landewé³, Florence Tubach^4,5, Maxime Dougados⁶ and D. van der Heijde⁷, ¹College of Osteopathic Medicine, Nova Southeastern University, Miami, FL, ²Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁴Département d'Epidémiologie Biostatistique et Recherche Clinique, APHP, Hôpital Bichat, Paris, France, ⁵INSERM, Universite Paris Diderot, Paris, France, ⁶Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, ⁷Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The minimum clinically important improvement (MCII) and patient acceptable symptom state (PASS) are clinically relevant measures that report the patient response and condition. We…
Abstract Number: 819 • ACR/ARHP Annual Meeting 2013
Low Diagnostic Utility Of Candidate Definitions For a Positive MRI Of The Spine In Axial Spondyloarthritis
Ulrich Weber¹, Veronika Zubler², Zheng Zhao³, Robert GW Lambert⁴, Kaspar Rufibach⁵, Stanley Chan⁶, Susanne Juhl Pedersen⁷, Mikkel Ostergaard⁸ and Walter P. Maksymowych⁹, ¹Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ²Radiology, Balgrist University Hospital, Zurich, Switzerland, ³Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵rePROstat, Basel, Switzerland, ⁶Division of Ophthalmology, University of Alberta, Edmonton, AB, Canada, ⁷Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ⁸Copenhagen Center for Arthritis Research, Glostrup, Denmark, ⁹Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: A recent consensus statement based on a systematic literature review by the Assessment of SpondyloArthritis International Society suggested the presence of ≥3 corner inflammatory…
Abstract Number: 2208 • ACR/ARHP Annual Meeting 2012
Referral Patterns and Diagnosis of Patients with Axial Spondyloarthritis: Results of an International Survey
Désirée van der Heijde¹, Joachim Sieper², Dirk Elewaut³, Aileen L. Pangan⁴ and Dianne Nguyen⁵, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, ³Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, ⁴Abbott Laboratories, Abbott Park, IL, ⁵Abbott Laboratories, Singapore, Singapore
Background/Purpose: This analysis compares referral patterns and diagnostic tools for axial spondyloarthritis (axSpA) used by rheumatologists working in academic centers and in community clinical practice…
Abstract Number: 1361 • ACR/ARHP Annual Meeting 2012
Disease Burden Is Comparable in Patients with Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis
Joachim Sieper¹, Désirée van der Heijde², Dirk Elewaut³, Aileen L. Pangan⁴ and Jaclyn K. Anderson⁴, ¹Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, ⁴Abbott Laboratories, Abbott Park, IL
Background/Purpose: Chronic back pain and functional impairment are disease characteristics common to all patients (pts) with axial spondyloarthritis (SpA), regardless of the presence of radiographic…