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Abstracts tagged "Ankylosing spondylitis (AS) and spondylarthropathy"

  • Abstract Number: 645 • 2017 ACR/ARHP Annual Meeting

    An Oral Tyk2 Inhibitor Effectively Suppresses the Development of Murine Th17 Cells In Vivo and Prevents Joint Damage in Experimental Ankylosing Spondylitis

    Eric Gracey1,2, Melissa Lim2, Zoya Qaiyum1, Yuriy Baglaenko1,2, Wenyan Miao3, Craig Masse3, William Westlin3 and Robert D Inman1,4, 1Department of Immunology, University of Toronto, Toronto, ON, Canada, 2Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 3Nimbus Therapeutics, Cambridge, MA, 4Toronto Western Hospital, University Health Network, toronto, ON, Canada

    Background/Purpose: Th17 cells play an important role in the pathogenesis of ankylosing spondylitis (AS). Tyk2, a member of the Janus Kinase (JAK) family of signaling…
  • Abstract Number: 2822 • 2015 ACR/ARHP Annual Meeting

    Increased Peripheral Blood CCR6+/IL-23R+ Gamma Delta T Cells Are Associated with High Disease Activity in Patients with Axial Spondyloarthritis

    Elizabeth Mainolfi1, Susan M. Goodman2, Shawn Anderson3, Jon Hill4, Thakker Paresh5, Meera Ramanujam6, Rivka Friedlander7, Elli Kim7, Dalit Ashany8, Ed Purdue9, Christine Averill9, Michael Nevid9, Allison Shaber9, Lisa Mandl10, Steven R. Goldring11, Gerald Nabozny1 and VP Bykerk2, 1Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 4Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 5Transl. Medicine & Clin. Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 6Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 7Department of Medicine, Rheumatology Division, Hospital for Special Surgery, New York, NY, 8Rheumatic Disease, Hospital for Special Surgery, New York, NY, 9Osteolysis Research Laboratory, Hospital for Special Surgery, New York, NY, 10Department of Rheumatology, Hospital for Special Surgery, New York, NY, 11Hospital for Special Surgery, New York, NY

    Background/Purpose:  The IL-23 axis and Th17 type immunity has been implicated in the pathogenesis  of Ankylosing Spondylitis (AS) and an enrichment of gamma delta (gd)…
  • Abstract Number: 2457 • 2013 ACR/ARHP Annual Meeting

    Ankylosing Spondylitis and a Diagnostic Dilemma: Coccydynia

    Rabia Deniz1, Gülsen Ozen2, Sibel Yilmaz-Oner2, Sibel Z. Aydin3, Can Erzik4, Osman Hakan Gunduz5, Nevsun Inanc6, Haner Direskeneli2 and Pamir Atagunduz6, 1Marmara University School of Medicine, Istanbul, Turkey, 2Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 3Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, 4Medical Biology, Marmara University School of Medicine, Istanbul, Turkey, 5Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey, 6Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey

    Background/Purpose: Coccydynia is defined as pain in or around the tail bone area. The most common cause of coccydynia is either a trauma such as…
  • Abstract Number: 1551 • 2013 ACR/ARHP Annual Meeting

    The Minimum Clinically Important Improvement and Patient Acceptable Symptom State In Basdai and BASFI For Patients With Ankylosing Spondylitis

    Milla Kviatkovsky1, Sofia Ramiro2, Robert Landewé3, Florence Tubach4,5, Maxime Dougados6 and D. van der Heijde7, 1College of Osteopathic Medicine, Nova Southeastern University, Miami, FL, 2Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 4Département d'Epidémiologie Biostatistique et Recherche Clinique, APHP, Hôpital Bichat, Paris, France, 5INSERM, Universite Paris Diderot, Paris, France, 6Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, 7Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The minimum clinically important improvement (MCII) and patient acceptable symptom state (PASS) are clinically relevant measures that report the patient response and condition. We…
  • Abstract Number: 819 • 2013 ACR/ARHP Annual Meeting

    Low Diagnostic Utility Of Candidate Definitions For a Positive MRI Of The Spine In Axial Spondyloarthritis

    Ulrich Weber1, Veronika Zubler2, Zheng Zhao3, Robert GW Lambert4, Kaspar Rufibach5, Stanley Chan6, Susanne Juhl Pedersen7, Mikkel Ostergaard8 and Walter P. Maksymowych9, 1Rheumatology, Balgrist University Hospital, Zurich, Switzerland, 2Radiology, Balgrist University Hospital, Zurich, Switzerland, 3Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, 4Radiology, University of Alberta, Edmonton, AB, Canada, 5rePROstat, Basel, Switzerland, 6Division of Ophthalmology, University of Alberta, Edmonton, AB, Canada, 7Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, 8Copenhagen Center for Arthritis Research, Glostrup, Denmark, 9Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: A recent consensus statement based on a systematic literature review by the Assessment of SpondyloArthritis International Society suggested the presence of ≥3 corner inflammatory…
  • Abstract Number: 2208 • 2012 ACR/ARHP Annual Meeting

    Referral Patterns and Diagnosis of Patients with Axial Spondyloarthritis: Results of an International Survey

    Désirée van der Heijde1, Joachim Sieper2, Dirk Elewaut3, Aileen L. Pangan4 and Dianne Nguyen5, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, 3Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, 4Abbott Laboratories, Abbott Park, IL, 5Abbott Laboratories, Singapore, Singapore

    Background/Purpose: This analysis compares referral patterns and diagnostic tools for axial spondyloarthritis (axSpA) used by rheumatologists working in academic centers and in community clinical practice…
  • Abstract Number: 1361 • 2012 ACR/ARHP Annual Meeting

    Disease Burden Is Comparable in Patients with Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis

    Joachim Sieper1, Désirée van der Heijde2, Dirk Elewaut3, Aileen L. Pangan4 and Jaclyn K. Anderson4, 1Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, 4Abbott Laboratories, Abbott Park, IL

    Background/Purpose: Chronic back pain and functional impairment are disease characteristics common to all patients (pts) with axial spondyloarthritis (SpA), regardless of the presence of radiographic…
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