Abstracts tagged "ankylosing spondylitis (AS) and human leukocyte antigens (HLA)"

Abstract Number: 1514 • 2017 ACR/ARHP Annual Meeting
Phenotype Differences in HLA-B27 Positive Versus Negative Patients with Ankylosing Spondylitis in a Population That Show Relatively Weaker Association with HLA-B27
Handan Yarkan¹, Zhixiu Li², Gokce Kenar³, Sedat Capar⁴, Fernur Çapa⁵, Rudi Steffensen⁶, Servet Akar⁷, Dilek Solmaz⁸, Pınar Cetin⁹, Berrin Zengin³, Erika de Guzman¹⁰, Katie Cremin², Gerçek Can¹¹, Zeynep Yüce⁵, Ismail Sari¹², Fatos Onen¹³, Matt Brown² and Nurullah Akkoc¹⁴, ¹Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, ²Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ³Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ⁴Statistics, Dokuz Eylul University School of Medicine, Izmir, Turkey, ⁵Department of Molecular Medicine, Dokuz Eylül University Health Sciences Institute, IZMIR, Turkey, ⁶Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ⁷Rheumatology, Izmir Katip Celebi University, School of Medicine, Rheumatology, Izmir, Turkey, ⁸Rheumatology, Izmir Katip Celebi University, School of Medicine, Rheumatology, izmir, Turkey, ⁹Rheumatology, Dokuz Eylul University Faculty of Medicine, izmir, Turkey, ¹⁰Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Austria, ¹¹TURKBIO, İzmir, Turkey, İzmir, Turkey, ¹²Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ¹³TURKBIO, İzmir, Turkey, Izmir, Turkey, ¹⁴Rheumatology, Private Practice, Rheumatology, İzmir, Turkey
Background/Purpose: The association of HLA-B*27 and ankylosing spondylitis (AS) is relatively weak in some populations. The aim of this study is to compare the clinical…
Abstract Number: 3163 • 2016 ACR/ARHP Annual Meeting
SEC16A and Intracellular Trafficking Abnormalities in Axial Spondyloarthritis
Fanxing Zeng¹, Zhenbo Zhang¹, Vidya Ranganathan², Darren Orielly³, Proton Rahman⁴ and Nigil Haroon⁵, ¹Krembil research institute, Toronto, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NF, Canada, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada
Background/Purpose: The pathogenesis of Axial Spondyloarthritis (AxSpA) is not well understood. A rare 9 base-pair deletion of SEC16A was recently identified to be strongly associated with AxSpA in a multiplex…

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