Abstracts tagged "Ankylosing spondylitis (AS) and genomics"

Abstract Number: 1612 • 2012 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Is Associated with Single Nucleotide Polymorphisms in Loci Implicating Four Aminopeptidases
Philip Robinson¹, Adrian Cortes¹, Paul Leo¹, Australian-Anglo-American Spondylitis Consortium (TASC)², Wellcome Trust Case Control Consortium (WTCCC) .³, International Genetics of Ankylosing Spondylosis Consortium (IGAS)⁴, David Evans⁵ and Matthew A. Brown¹, ¹Human Genetics Group, University of Queensland Diamantina Insititute, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, ³Wellcome Trust Case Control Consortium, Wellcome Trust Case Control Consortium, United Kingdom, ⁴IGAS, Igas, Australia, ⁵School of Social and Community Medicine, Bristol University, Bristol, United Kingdom
Background/Purpose: The aim of the study was to examine regions implicated in autoimmune diseases for association with AS. A previous association with AS has been…
Abstract Number: 595 • 2012 ACR/ARHP Annual Meeting
A Genomewide Association Study of Anterior Uveiti
Dorith Claushuis¹, Adrian Cortes², Linda A. Bradbury¹, Tammy M. Martin³, James T. Rosenbaum⁴, John D. Reveille⁵, Paul Wordsworth⁶, Jennifer Pointon⁶, Australo-Anglo-American Spondyloarthritis Consortium⁷, David Evans⁸, Paul Leo², Pamela Mukhopadhyay² and Matthew A. Brown², ¹Human Genetics Group, The University of Queensland Diamantina Institute, Brisbane, Australia, ²Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ³Ophthalmology/L467AD, Oregon Health & Science Univ, Portland, OR, ⁴Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁶Ndorms, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁷Houston, TX, ⁸School of Social and Community Medicine, Bristol University, Bristol, United Kingdom
Background/Purpose: Anterior uveitis (AU) is the most common extra-articular manifestation of ankylosing spondylitis (AS), occurring in up to 30-40% of AS cases. The aim of…
Abstract Number: 588 • 2012 ACR/ARHP Annual Meeting
Discovery of Two Public T Cell Receptor Clonotypes in B27+ Ankylosing Spondylitis by Deep Repertoire Sequence Analysis
Malek Faham¹, Victoria Carlton² and Robert D. Inman³, ¹Research, Sequenta, Inc., South San Francisco, CA, ²Sequenta, Inc., South San Francisco, CA, ³Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: The strong association of AS with HLA-B27 implicates a T cell response restricted by this Class I MHC molecule, predicting that specific T Cell…

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