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Abstracts tagged "Ankylosing spondylitis (AS) and anti-TNF therapy"

  • Abstract Number: 680 • 2018 ACR/ARHP Annual Meeting

    Unmet Needs in the Treatment of Ankylosing Spondylitis. a Long-Term Observational Study from a Single University Center

    Eleftherios Pelechas1, Evripidis Kaltsonoudis2, Paraskevi V. Voulgari3 and Alexandros Drosos4, 1Rheumatology Clinic, Department οf Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, Fellow in Rheumatology, Ioannina, Greece, 2Rheumatology Clinic, Department of Internal Medicine, Rheumatologist, Ioannina, Greece, 3Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Professor of Rheumatology, Ioannina, Greece, 4Rheumatology Clinic, Department of Internal Medicine, Medical School University of Ioannina, Ioannina, Greece, Professor of Medicine/Rheumatology, Ioannina, Greece

    Background/Purpose: Despite the progress in the treatment of ankylosing spondylitis (AS), a significant number of patients does not achieve low disease activity (LDA). The aim…
  • Abstract Number: 654 • 2017 ACR/ARHP Annual Meeting

    Effect of Anti Tnfα Drugs on the Frequency of Circulating CD19+CD24hiCD38hi Breg Cells in Ankylosing Spondylitis

    M. Belén Bautista-Caro1, Eugenio De Miguel1, Diana Peiteado1, Alejandro Villalba1, Irene Monjo1, Amaya Puig-Kröger2, Paloma Sanchez-Mateos3, Emilio Martín-Mola1 and Maria Eugenia Miranda-Carus1, 1Rheumatology, Hospital La Paz-IdiPAZ, Madrid, Spain, 2Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain, 3Immunology, Hospital Gregorio Marañon, Madrid, Spain

    Background/Purpose: CD19+CD24hiCD38hi B cells demonstrate a regulatory capacity and their frequency is altered in the peripheral blood of patients with various autoimmune diseases. The pathogenic…
  • Abstract Number: 701 • 2016 ACR/ARHP Annual Meeting

    In Patients with Ankylosing Spondylitis Treated with Adalimumab, Combination Therapy with DMARD, Increase the Serum Level of Adalimumab and Decrease Immunogenicity

    José Rosas1, Francisca Llinares-Tello2, José Miguel Senabre-Gallego1, Mariana Marco-Mingot3, Ana Pons1, Xavier Barber4, Gregorio Santos-Soler1, Esteban Salas-Heredia1, Catalina Cano1, Juan Molina3, Marina Sanchís4, Mario García-Carrasco5 and AIRE-MB Group, 1Rheumatology, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 2Laboratory, Hospital Marina Baixa, Villajoyosa, Spain, 3Laboratory, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 4CIO, Universidad Miguel Hernández, Elche, Spain, 5Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico

    Background/Purpose: In patients with rheumatoid arthritis, methotrexate (MTX), improves the clinical efficacy of anti-TNF (TNFi), among other reasons, for reducing the immunogenicity. However, there are…
  • Abstract Number: 702 • 2016 ACR/ARHP Annual Meeting

    Treatment with Golimumab or Infliximab Reduces Health Resource Utilization and Increases Work Productivity in Patients with Ankylosing Spondylitis in a Large, Prospective Real-Life Cohort

    Pascal Claudepierre1, Filip van Den Bosch2, Piercarlo Sarzi-Puttini3, Shiva Sajjan4, N Vastesaeger5, Marinella Govoni6 and Sumesh Kachroo7, 1Hôpital Henri Mondor, Créteil, France, 2Rheumatology, Ghent University Hospital, Ghent, Belgium, 3Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, 4Merck & Co., Inc., Kenilworth, NJ, 5Merck Sharp & Dohme, Belgium, Brussels, Belgium, 6Via Tasso 14, Merck Sharp & Dohme, Italy, Cento, Italy, 7CORE, Merck & Co., Inc., Kenilworth, NJ

    Background/Purpose: We evaluated the effect of the anti-tumor necrosis factor (TNF) agents, golimumab (GLM) and infliximab (IFX), on healthcare resource utilization (HCRU) and work productivity…
  • Abstract Number: 720 • 2016 ACR/ARHP Annual Meeting

    Impact of HLA-B27 on Patient Profile and Treatment Response in As Patients Treated with Anti-TNF in Canadian Real-World

    Isabelle Fortin1, Maqbool Sheriff2, Proton Rahman3, Michael Starr4, Wojciech Olszynski5, Sanjay Dixit6, Viktoria Pavlova7, Derek Haaland8, Emmanouil Rampakakis9, Eliofotisti Psaradellis10, Brendan Osborne11, Karina Maslova12, Allen J Lehman12, Francois Nantel13 and Cathy Tkaczyk11, 1Centre de Rhumatologie De l’Est du Quebec, Rimouski, QC, Canada, 2Nanaimo Regional General Hospital, Nanaimo, BC, Canada, 3Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, 4Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, 5103 Midtown Professional Center, Rheumatology Associates of Saskatoon, Saskatoon, SK, Canada, 6Rheumatology, McMaster University Hamilton, Burlington, ON, Canada, 7Ancaster Medical Centre, Ancaster, ON, Canada, 8Rheumatology, Clinical Immunology & Allergy, McMaster University, Barrie, ON, Canada, 9JSS Medical Research, St-Laurent, QC, Canada, 10JSS Medical Research, Montreal, QC, Canada, 11Medical Affairs, Janssen Inc., Toronto, ON, Canada, 12Janssen Inc., Toronto, ON, Canada, 1319 Green belt Dr, Janssen Inc., Toronto, ON, Canada

    Background/Purpose:  The human leukocyte antigen (HLA)-B27 allele is one of the strongest known genetic factors associated with the development of ankylosing spondylitis, however, previous studies…
  • Abstract Number: 730 • 2016 ACR/ARHP Annual Meeting

    Clinical and Quality of Life Improvements Observed with Golimumab and Infliximab in a Large Real-Life Ankylosing Spondylitis Population

    Filip van Den Bosch1, Rene-Marc Flipo2, Jürgen Braun3, Shiva Sajjan4, N Vastesaeger5, Sumesh Kachroo6 and Marinella Govoni7, 1Rheumatology, Ghent University Hospital, Ghent, Belgium, 2Rheumatology, University Hospital, Lille, France, 3Rheumazentrum Ruhrgebiet, Herne, Germany, 4Merck & Co., Inc., Kenilworth, NJ, 5Merck Sharp & Dohme, Belgium, Brussels, Belgium, 6CORE, Merck & Co., Inc., Kenilworth, NJ, 7Via Tasso 14, Merck Sharp & Dohme, Italy, Cento, Italy

    Background/Purpose : We assessed baseline parameters associated with health-related quality-of-life (HRQoL) improvement in AS patients with anti-TNF treatment (golimumab [GLM]; infliximab [IFX; originator]) in the…
  • Abstract Number: 1257 • 2016 ACR/ARHP Annual Meeting

    Gender Differences in Ankylosing Spondylitis Patients Treated with Anti-TNF in Daily Practice with Ten Year Follow up

    T. Rusman1,2, S. ten Wolde3, S.M. Euser4,5, T. van der Ploeg4,6, O. van Hall1,3 and I.E. Van der Horst - Bruinsma7, 1Rheumatology, VU University medical centre, Amsterdam, Netherlands, 2Rheumatology, Linnaesinstituut Spaarne Gasthuis, Haarlem, Netherlands, 3Rheumatology, Spaarne Gasthuis, Haarlem, Netherlands, 4Linnaesinstituut Spaarne Gasthuis, Haarlem, Netherlands, 5Regional Laboratory of Public Health Kennemerland, Haarlem, Netherlands, 6Spaarne Medical centre, Alkmaar, Netherlands, 7Amsterdam Rheumatology immunology Center |Departments of Rheumatology VU University Medical Center & Reade, Amsterdam, Netherlands

    Background/Purpose: Anti-TNF treatment is available for Ankylosing Spondylitis (AS) for many years now, but the data on long term follow up in daily practice are…
  • Abstract Number: 1258 • 2016 ACR/ARHP Annual Meeting

    Female Gender Is Associated with a Poorer Response to TNF-Inhibitors in Ankylosing Spondylitis

    T. Rusman1, M. Nurmohamed2, J.C. van Denderen3, I. Visman4 and I.E. Van der Horst - Bruinsma2, 1Rheumatology, VU University medical centre, Amsterdam, Netherlands, 2Amsterdam Rheumatology immunology Center |Departments of Rheumatology VU University Medical Center & Reade, Amsterdam, Netherlands, 3Center for Rheumatology and Rehabilitation, Jan van Breemen Institute, Amsterdam, Netherlands, 4Amsterdam Rheumatology and Immunology Center, VUmc and Reade, Amsterdam, Netherlands

    Background/Purpose: Limited data is available on the influence of smoking, Body Mass Index (BMI) and gender on disease activity and response to TNF inhibitors in…
  • Abstract Number: 2749 • 2016 ACR/ARHP Annual Meeting

    Characteristics of Ankylosing Spondylitis Patients with Primary and Secondary Lack of Efficacy to TNF-Inhibitor Treatments

    Mansour Alazmi1, Ismail Sari1, Renise Ayearst2, Nigil Haroon1 and Robert D Inman1, 1Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, 2Medicine, University Health Network, Toronto, ON, Canada

    Background/Purpose: Anti-TNFi agents are effective in the treatment of active AS. Based on the available data, nearly 20% of the AS patients needed to switch…
  • Abstract Number: 2837 • 2015 ACR/ARHP Annual Meeting

    Sulfasalazine Comedication: A Predictor of Reduced Long-Term Anti-TNF Switch in Ankylosing Spondylitis

    Andrea Y. Shimabuco, Celio R. Gonçalves, Julio C. B. Moraes, Mariana G Waisberg, Percival D Sampaio-Barros, Cláudia Goldenstein-Schainberg, Eloisa Bonfá and Carla G.S. Saad, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Anti-TNF agents are efficacious in the treatment of ankylosing spondylitis (AS). The switch to another TNF blockage can be an alternative in cases of…
  • Abstract Number: 2555 • 2014 ACR/ARHP Annual Meeting

    The Effect of Co-Medication with Conventional Synthetic (cs)Dmards on Achieving Low Disease Activity While Persisting on Adalimumab Therapy in Patients with Ankylosing Spondylitis/ Axial Spondylarthritis (AS)– Analysis from the Czech Biologics Registry Attra

    Karel Pavelka1, Jakub Zavada2, Marketa Fojtikova3, Sarka Forejtova4 and Karel Hejduk5, 1Institute of Rheumatology, Prague, Czech Republic, 2Charles University, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 4Rheumatology, Institute of Rheumatology, Prague, Czech Republic, 5Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic

    Background/Purpose : The role of combined treatment with csDMARDs and anti-TNF therapy in AS is not well established. Methods: Main goal of this study was…
  • Abstract Number: 2563 • 2014 ACR/ARHP Annual Meeting

    The Distribution of Inflammatory Lesions in the Anterior and Posterior Structures of the Spine in Patients with Active Ankylosing Spondylitis and the Effect of TNF-α-Blockade

    Xenofon Baraliakos1, Kay-Geert A. Hermann2, Stephen Xu3, Benjamin Hsu3 and Jürgen Braun1, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Radiology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, 3Janssen Research & Development, LLC., Spring House, PA

    Background/Purpose Magnetic resonance imaging (MRI) is a key tool for the assessment of inflammatory lesions used for diagnosis and the monitoring of treatment effects in…
  • Abstract Number: 957 • 2014 ACR/ARHP Annual Meeting

    Long-Term Evaluation of NT-Probnp Levels in Ankylosing Spondylitis Patients Under TNF Blockers: A Marker of Persistent Disease Activity?

    Debora Russo1, Carla G.S. Saad2, Ana C.M. Ribeiro1, Cláudia Goldeinstein-Schainberg2, Percival D Sampaio-Barros2, Celio R. Gonçalves2, Eloisa Bonfá1 and Julio C. B. Moraes2, 1Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong marker of cardiovascular risk with recent evidence that short-term inflammation control reduces its levels in ankylosing…
  • Abstract Number: 851 • 2014 ACR/ARHP Annual Meeting

    A Tailored Approach to Reduce Dose of Anti-TNF Drugs Is Equally Effective, but Substantially Less Costly Than Standard Dosing in Patients with Ankylosing Spondylitis over One Year: A Propensity Score-Matched Cohort Study

    Jakub Zavada1, Michal Uher2, Katarina Sisol3, Sarka Forejtova4, Katerina Jarosova5, Herman F. Mann6, Jiri Vencovsky7 and Karel Pavelka8, 1Charles University, Prague, Czech Republic, 2Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic, 3rheumatology, Institute of Rheumatology, Prague, Czech Republic, 4Rheumatology, Institute of Rheumatology, Prague, Czech Republic, 5Na Slupi 4, Institute of Rheumatology, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 7Institute of Rheumatology and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 8Institute of Rheumatology, Praha, Czech Republic

    Background/Purpose: To compare effectiveness, safety and costs of standard versus individually tailored reduced doses of anti-TNF drugs in patients with Ankylosing Spondylitis (AS) after achieving…
  • Abstract Number: 2462 • 2013 ACR/ARHP Annual Meeting

    Comparison Of Tumor Necrosis Factor Inhibitor Use For Ankylosing Spondylitis At University Rheumatology Clinics In Scotland and Oregon

    Anusha Reddy1, Abhijeet Danve2, Kiana Vakil-Gilani3, Jennifer H. Ku4, Sanjay Ganhasan5, Alison Black6 and Atul A. Deodhar3, 1Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 2Rheumatology, Oregon Health and Science University, Portland, OR, 3Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR, 4Arthritis and Rheumatic Diseases, Oregon Health and Science University, Portland, OR, 5Forresterhill Rd Aberdeen AB25 2ZN, United Kingdom, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 6Aberdeen Royal Infirmary, Aberdeen, United Kingdom

    Background/Purpose: Use of tumor necrosis factor inhibitors (TNFi) for ankylosing spondylitis (AS) is directed by national guidelines in the UK. However in the US, in…
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