Abstracts tagged "animal models and treatment"

Abstract Number: 1326 • ACR/ARHP Annual Meeting 2017
Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis
Lingshu Zhang^1,2, Pingfang Song², Xiaowei Zhang², Christina Metea², Matthew Schleisman², Lisa Karstens², Eric Leung², Jun Zhang³, Qiang Xu^2,4, Yi Liu⁵, Mark Asquith² and Cong-Qiu Chu^6,7, ¹Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, China, ²Oregon Health & Science University, Portland, OR, ³MD Anderson Cancer Center, Houston, TX, ⁴Guangzhou University of Chinese Medicine, Guangzhou, China, ⁵Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, ⁶Rheumatology, Oregon Health & Science University, Portland, OR, ⁷Rheumatology, VA Portland Health Care System, Portland, OR
Background/Purpose: Acarbose, an alpha-glucosidase inhibitor anti-diabetic drug exhibited anti-arthritic effects. The mechanism that acarbose exerts its anti-arthritic effects is not fully understood. Since > 90%…
Abstract Number: 2234 • ACR/ARHP Annual Meeting 2013
Targeting Therapy Of Citrullinated Antigen-Specific B Cells Ameliorates Collagen-Induced Arthritis
Kazuya Michishita¹, Kimito Kawahata¹, Takeyuki Kanzaki², Lisa Akahira¹, Toshiki Eri¹ and Kazuhiko Yamamoto³, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan, ³Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose: The clinical benefit of B-cell depletion therapy in rheumatoid arthritis(RA) is a well-known fact, but problems such as relapse of tuberculosis and reactivation of…
Abstract Number: 2083 • ACR/ARHP Annual Meeting 2012
New Treatment Approach of Rheumatoid Arthritis Based On Inhibition of Cyclin Dependent Kinase-9
Annelie Hellvard¹, Lutz Zeitlmann², Ulrich Heiser³, André Niestroj³, Hans-Ulrich Demuth³, Jan Potempa⁴ and Piotr Mydel¹, ¹Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway, ²Ingenium Pharmaceuticals GmbH, Martinsried, Germany, ³Probiodrug AG, Halle/Saale, Germany, ⁴Microbiology Department, Jagiellonian University, Krakow, Poland
Background/Purpose: Cyclin dependent kinase-9 (cdk-9) is transcription regulator of the carboxyterminal domain of RNA polymerase II. The usage of pan-cdk inhibitors such as flavopiridol has…