ACR Meeting Abstracts

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Abstracts tagged "animal models and treatment"

  • Abstract Number: 1326 • 2017 ACR/ARHP Annual Meeting

    Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

    Lingshu Zhang1,2, Pingfang Song2, Xiaowei Zhang2, Christina Metea2, Matthew Schleisman2, Lisa Karstens2, Eric Leung2, Jun Zhang3, Qiang Xu2,4, Yi Liu5, Mark Asquith2 and Cong-Qiu Chu6,7, 1Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, China, 2Oregon Health & Science University, Portland, OR, 3MD Anderson Cancer Center, Houston, TX, 4Guangzhou University of Chinese Medicine, Guangzhou, China, 5Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, 6Rheumatology, Oregon Health & Science University, Portland, OR, 7Rheumatology, VA Portland Health Care System, Portland, OR

    Background/Purpose: Acarbose, an alpha-glucosidase inhibitor anti-diabetic drug exhibited anti-arthritic effects. The mechanism that acarbose exerts its anti-arthritic effects is not fully understood. Since > 90%…
  • Abstract Number: 2234 • 2013 ACR/ARHP Annual Meeting

    Targeting Therapy Of Citrullinated Antigen-Specific B Cells Ameliorates Collagen-Induced Arthritis

    Kazuya Michishita1, Kimito Kawahata1, Takeyuki Kanzaki2, Lisa Akahira1, Toshiki Eri1 and Kazuhiko Yamamoto3, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan, 3Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Background/Purpose: The clinical benefit of B-cell depletion therapy in rheumatoid arthritis(RA) is a well-known fact, but problems such as relapse of tuberculosis and reactivation of…
  • Abstract Number: 2083 • 2012 ACR/ARHP Annual Meeting

    New Treatment Approach of Rheumatoid Arthritis Based On Inhibition of Cyclin Dependent Kinase-9

    Annelie Hellvard1, Lutz Zeitlmann2, Ulrich Heiser3, André Niestroj3, Hans-Ulrich Demuth3, Jan Potempa4 and Piotr Mydel1, 1Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway, 2Ingenium Pharmaceuticals GmbH, Martinsried, Germany, 3Probiodrug AG, Halle/Saale, Germany, 4Microbiology Department, Jagiellonian University, Krakow, Poland

    Background/Purpose: Cyclin dependent kinase-9 (cdk-9) is transcription regulator of the carboxyterminal domain of RNA polymerase II. The usage of pan-cdk inhibitors such as flavopiridol has…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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