ACR Meeting Abstracts

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Abstracts tagged "animal models and transcription factor"

  • Abstract Number: 47 • 2018 ACR/ARHP Annual Meeting

    Analysis of the Role of RORγt+Foxp3+ T Regulatory 17 (Tr17) Cells in Murine Autoimmune Arthritis Model

    Kotona Furuyama1, Yuya Kondo1, Masaru Shimizu2, Iizuka Akira1, Masahiro Yokosawa1, Seiji Segawa1, Hiroto Tsuboi1, Isao Matsumoto1 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: RORγt+Foxp3+ regulatory T (Treg) cells, designated as Tr17 is one of the new subset of Treg cells, having the potential to regulate the development…
  • Abstract Number: 1290 • 2013 ACR/ARHP Annual Meeting

    Pro-Inflammatory and Anti-Inflammatory Roles Of Interferon Regulatory Factor 5 In The Development Of Collagen-Induced Arthritis

    Yoshifumi Tada1, Syuichi Koarada1, Rie Suematsu1, Satoko Tashiro1, Natsumi Nagao1 and Akihide Ohta2, 1Rheumatology, Saga University, Saga, Japan, 2Nursing, Saga University, Saga, Japan

    Background/Purpose: Interferon regulatory factor 5 (IRF5) is a transcription factor that mediates signals activated by engagement of Toll-like receptors (TLRs). IRF5 polymorphisms are associated with…
  • Abstract Number: 2074 • 2012 ACR/ARHP Annual Meeting

    Combined Effects of a c-Fos/AP-1 Inhibitor T-5224 and Methotrexate On Collagen-Induced Arthritis in Mice

    Tomomi Date1, Yukihiko Aikawa1, Tetsuya Yamamoto1, Hirokazu Narita1, Shuichi Hirono2 and Shunichi Shiozawa3, 1Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan, 2Department of Pharmaceutical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan, 3Department of Medicine & Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose: Activator protein-1 (AP-1) is an important transcription factor for cytokine production and joint destruction in rheumatoid arthritis (RA), and a potential target for the…
  • Abstract Number: 2075 • 2012 ACR/ARHP Annual Meeting

    CCR6+ Foxp3+ Regulatory T Cells Regulate the Development of Collagen Induced Arthritis in T Cell Specific RORγt Transgenic Mice

    Yuya Kondo1, Masahiro Tahara1, Mana Iizuka1, Hiroto Tsuboi1, Satoru Takahashi2, Isao Matsumoto1 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Department of Anatomy and Embryology, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Recent studies reported that IL-17 producing Th-17 cells appear to play an important role in the generation of several autoimmune arthritis models. We previously…
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