Abstracts tagged "animal models and spondylarthritis"

Abstract Number: 2174 • 2016 ACR/ARHP Annual Meeting
Effect of Anti-Rheumatic Treatment on Selenium Levels in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Gia Deyab¹, Ingrid Hokstad², Milada Cvancarova Småstuen³, Stefan Agewall⁴, Jon Elling Whist⁵ and Ivana Hollan^5,6,7,8, ¹Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway, ²Lillehammer Hospitat for Rheumatic Diseases, Lillehammer, Norway, ³Institution of health care - Health science PhD program, Oslo and Akershus University College, Oslo, Norway, ⁴University of Oslo, Oslo, Norway, ⁵Innlandet Hospital Trust, Lillehammer, Norway, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷Harvard Medical School, Boston, MA, ⁸Lillehammer Hospital for Rheumatic Diseases, Lillahammer, Norway
Background/Purpose: The cause of the increased cardiovascular risk in inflammatory rheumatic diseases (IRDs) is still unclear. Intriguingly, selenium-deficiency, which might be caused by poor diet or…
Abstract Number: 2697 • 2016 ACR/ARHP Annual Meeting
Modulator Role of Inducible Costimulator (ICOS) in Spondyloarthritis Animal Model
Luiza Krause¹, Quentin Jouhault², Bilade Cherqaoui¹, Aude Jobart-Malfait¹, Ignacio Anegon³, Gilles Chiocchia⁴ and Maxime A. Breban⁵, ¹INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ²Infection and inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ³U643, INSERM-UMR643- Nantes-CHU, Nantes, France, ⁴Infection and Inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ⁵Rheumatology, Ambroise Paré Hospital, and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: HLA-B27/hβ2m transgenic rats (B27 rats), a model of spondylarthritis (SpA) develop spontaneous colitis and arthritis. Recently, in vitro studies demonstrated that altered dendritic cells…
Abstract Number: 2698 • 2016 ACR/ARHP Annual Meeting
Regulation of Inflammation By Interleukin-27 in a Rat Model of Spondyloarthritis (SpA)
Quentin Jouhault¹, Maxime A. Breban², Luiza Krause³ and Gilles Chiocchia³, ¹Infection and inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ²Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ³Infection and Inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France
Background/Purpose: SpA is a chronic inflammatory rheumatic disorder with osteo-articular and extra-articular manifestations. HLA-B27/human β2-microglobulin transgenic rats (B27 rat) spontaneously develop a phenotype closely resembling…
Abstract Number: 981 • 2015 ACR/ARHP Annual Meeting
Anti-IL-17A Treatment Blocks Inflammation, Destruction and New Bone Formation in Experimental Spondyloarthritis in HLA-B27 Transgenic Rats
Melissa van Tok^1,2, Leonie van Duivenvoorde^1,3, Ina Kramer⁴, Peter Ingold⁴, Joel Taurog⁵, Frank Kolbinger⁴ and Dominique Baeten^1,2, ¹Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ²Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Novartis Institutes for Biomedical Research, Basel, Switzerland, ⁵Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: The IL-17 axis has been identified as a crucial pathophysiological pathway in spondyloarthritis (SpA). Targeting the IL-17 axis significantly suppressed inflammation and halted bone…
Abstract Number: 620 • 2014 ACR/ARHP Annual Meeting
Innate Immune Stimulation Triggers Altered IL-1a/b Gene Expression and Experimental Spondyloarthritis in HLA-B27/huβ2m Transgenic Rats
Melissa N. van Tok^1,2, Leonie M. van Duivenvoorde³, Nimman Satumtira⁴, Martha L. Dorris⁴, Joel D. Taurog⁴ and Dominique L. Baeten¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Spondyloarthritis (SpA) does not display typical features of autoimmune diseases such as female predominance, presence of autoantibodies, or clinical response to T- and/or B…

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