Abstracts tagged "animal models and rheumatoid arthritis (RA)"

Abstract Number: 1827 • 2018 ACR/ARHP Annual Meeting
Genetic Ablation of Phd Finger Protein 19 Gene Promotes Autoimmune Arthritis in Mice
Tibor T. Glant¹, Timea Ocskó², Daniel M. Tóth¹, Adrienn Markovics¹ and Tibor A. Rauch¹, ¹Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Orthopedic Surgery, Rush University Medical Center, Chicago, IL
Background/Purpose: Understanding the genetic and epigenetic background of rheumatoid arthritis (RA) is complex since multiple genes and environmental factors are involved. By conducting congenic mapping…
Abstract Number: 294 • 2017 ACR/ARHP Annual Meeting
DNA Area and Netosis Analysis (DANA): A High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images
Ryan Rebernick¹, Lauren Fahmy², Christopher Glover², Nicole Rademacher², Hemanth Potluri², Mandar Bawadekar¹, Christie M. Bartels³ and Miriam A. Shelef^1,4, ¹Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ²University of Wisconsin - Madison, Madison, WI, ³Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI, ⁴William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: Neutrophil extracellular traps (NETs), extracellular structures composed of decondensed chromatin, are released in a process called NETosis. NETs, which are part of normal host…
Abstract Number: 2556 • 2015 ACR/ARHP Annual Meeting
Functional Genetics of PTPN2 in Rheumatoid Arthritis: Haploinsufficiency of PTPN2 Promotes Severity of CD4+ T-Cell Mediated Autoimmune Arthritis
Mattias N.D Svensson¹, Karen M. Doody¹, Cristiano Sacchetti¹, Dennis J. Wu¹, Gisen Kim², Annelie Hellvard³, Brith Bergum³, Piotr Mydel³, Mitchell Kronenberg², Michel L. Tremblay⁴ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁴Goodman Cancer Centre, McGill University, Montréal, QC, Canada
Background/Purpose: Several genome-wide associations studies have in recent years linked polymorphisms in the PTPN2 locus to rheumatoid arthritis (RA) and other autoimmune diseases. PTPN2 encodes…
Abstract Number: 2346 • 2014 ACR/ARHP Annual Meeting
Specific Overexpression of FPR2(FPRL-1) on Th1 Cells in GPI-Induced Arthritis and Patients with Rheumatoid Arthritis
Yuki Tanaka¹, Isao Matsumoto², Asuka Inoue³, Naoto Umeda⁴, Chinatsu Takai⁵, Yuko Kurashima⁶, Hoshimi Kawaguchi⁶ and Takayuki Sumida⁷, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Interenal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ⁴Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan, ⁵University of Tsukuba, Ibaraki, Japan, ⁶University of Tsukuba, Tsukuba, Japan, ⁷Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
【Background/Purpose 】 CD4+T cell are critical to the pathogenesis of rheumatoid arthritis (RA). In glucose-6-phosphate isomerase (GPI) induced-arthritis (GIA), Th1 and Th17 cells are indispensable…

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