Abstracts tagged "Animal models and inflammation"

Abstract Number: 1783 • 2019 ACR/ARP Annual Meeting
Reversible Dysregulation of Renal Circadian Rhythm in Lupus Nephritis
Rakesh Mishra ¹, Ramalingam Bethunaickan ¹, Celine Berthier ², Zhengzi Yi ³, Joshua Strohl ¹, Patricio Huerta ¹, Weijia Zhang ⁴ and Anne Davidson⁵, ¹Feinstein Institute for Medical Research, manhasset, NY, ²University of Michigan, Ann Arbor, MI, ³Mount Sinai School of Medicine, New York, ⁴Mount Sinai School of Medicine, New York, NY, ⁵Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: Circadian rhythm is a universal phenomenon that governs homeostasis of overall organism functioning as well as of individual organs. Circadian regulation of homeostatic functions…
Abstract Number: 1068 • 2012 ACR/ARHP Annual Meeting
A Selective Inhibitor of Endosomal Toll-Like Receptors, IMO-8400, Suppresses Activation of Multiple Cytokines, Th17 Response and Inflammasome Activation
Weiven Jiang, Fugang Zhu, Dong Yu, Ekambar R. Kandimalla, Nicola La Monica and Sudhir Agrawal, Discovery, Idera Pharmaceuticals, Cambridge, MA
Background/Purpose: In autoimmune diseases, activation of Th1 and Th17 pathways has been associated with disease maintenance and progression. Engagement of endosomal Toll-like receptors (TLRs) 7,…

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