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Abstracts tagged "animal models and autoimmune diseases"

  • Abstract Number: 2059 • ACR/ARHP Annual Meeting 2016

    Serine/Arginine-Rich Splicing Factor 1 (SRSF1) Is a Novel Factor in T Cell Homeostasis and Its Selective Loss in T Cells Causes Autoimmunity and Lupus-like Nephritis

    Vaishali R. Moulton1, Hao Li2, Michael W. Mosho2, Andrew R. Gillooly2, Meghan L. Keane3 and George C. Tsokos4, 1Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) express reduced amounts of the critical CD3 zeta signaling chain, and produce low levels of…

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