Abstracts tagged "Angiotensin"

Abstract Number: 1146 • 2018 ACR/ARHP Annual Meeting
The Association of Raas Inhibitor Use with Osteoporosis. Findings from the Women’s Health Initiative
Laura Carbone¹, Sowmya Vassan², Ross Prentice², Greg Harshfield¹, Bernhard Haring³, Jane A. Cauley⁴ and Karen Johnson⁵, ¹Medical College of Georgia at Augusta University, Augusta, GA, ²Fred Hutchinson Cancer Research Center, Seattle, WA, ³University of Wurzburg, Bavaria, Germany, ⁴University of Pittsburgh, PIttsburgh, PA, ⁵University of TN Health Science Center, Memphis, TN
Background/Purpose: Experimental studies have implicated a role for the Renin Angiotensin Aldosterone System (RAAS) in osteoporosis. However, the relationship of pharmacological inhibition of the RAAS…
Abstract Number: 468 • 2016 ACR/ARHP Annual Meeting
Angiotensin II Exacerbates Bone Destruction in TNF-Transgenic Arthritis Mice
Takafumi Mito¹, Tomoyuki Mukai², Shunichi Fujita², Akiko Nagasu², Hiroyasu Hirano², Teruki Sone³ and Yoshitaka Morita², ¹rheumatology, Kawasaki medical school, Okayama, Japan, ²Rheumatology, Kawasaki medical school, Okayama, Japan, ³Nuclear Medicine, Kawasaki medical school, Okayama, Japan
Background/Purpose: Angiotensin II (Ang II) is known to function on various organs including kidneys, adrenal glands as well as the nervous and cardiovascular systems. In…
Abstract Number: 1712 • 2014 ACR/ARHP Annual Meeting
Monocytic Angiotensin and Endothelin Receptor Imbalance Determines Secretion of the Profibrotic Chemokine Ligand CCL18
Judith Rademacher¹, Jeannine Guenther², Angela Kill³, Elise Siegert⁴ and Gabriela Riemekasten⁵, ¹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, 10117 Berlin, Germany, ²Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, ³Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ⁵Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose Circulating monocytes are progrenitor of extra-cellular matrix producing cells involved in fibrosis and show highest expression of angiotensin II (ATR) and endothelin receptors (ETR)…
Abstract Number: 2230 • 2013 ACR/ARHP Annual Meeting
Specific Angiotensin Type II Receptor Stimulation Attenuates Collagen-Induced Arthritis Via Enhancement Of FoxP3 Regulatory T Cells
Bettina Sehnert¹, Veronica Valero-Esquitino², Georg Schett³, Ulrika Muscha Steckelings² and Reinhard E. Voll⁴, ¹Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency,, University Hospital Freiburg, Freiburg, Germany, ²Center for Cardiovascular Research, Medical Faculty Berlin, Berlin, Germany, ³Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany
Background/Purpose: The renin-angiotensin system (RAS) is known to play an important role in inflammation, fibrosis, and end-organ damage. Moreover, AT2R signalling exerts anti-inflammatory and anti-apoptotic…
Abstract Number: 1491 • 2012 ACR/ARHP Annual Meeting
Systemic Sclerosis – Effects of Agonistic Autoantibodies Directed Against the Angiotensin Receptor Type 1 and the Endothelin Receptor Type A On Effector Cells
Jeannine Guenther¹, Angela Kill², Mike O. Becker³ and Gabriela Riemekasten⁴, ¹Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, ²Rheumatology and clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁴Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose: Autoimmunity, vasculopathy and fibrosis are features of systemic sclerosis (SSc). The functional link between these three pathophysiological components is still missing. Research suggests an…