ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Angiotensin"

  • Abstract Number: 1146 • 2018 ACR/ARHP Annual Meeting

    The Association of Raas Inhibitor Use with Osteoporosis. Findings from the Women’s Health Initiative

    Laura Carbone1, Sowmya Vassan2, Ross Prentice2, Greg Harshfield1, Bernhard Haring3, Jane A. Cauley4 and Karen Johnson5, 1Medical College of Georgia at Augusta University, Augusta, GA, 2Fred Hutchinson Cancer Research Center, Seattle, WA, 3University of Wurzburg, Bavaria, Germany, 4University of Pittsburgh, PIttsburgh, PA, 5University of TN Health Science Center, Memphis, TN

    Background/Purpose: Experimental studies have implicated a role for the Renin Angiotensin Aldosterone System (RAAS) in osteoporosis. However, the relationship of pharmacological inhibition of the RAAS…
  • Abstract Number: 468 • 2016 ACR/ARHP Annual Meeting

    Angiotensin II Exacerbates Bone Destruction in TNF-Transgenic Arthritis Mice

    Takafumi Mito1, Tomoyuki Mukai2, Shunichi Fujita2, Akiko Nagasu2, Hiroyasu Hirano2, Teruki Sone3 and Yoshitaka Morita2, 1rheumatology, Kawasaki medical school, Okayama, Japan, 2Rheumatology, Kawasaki medical school, Okayama, Japan, 3Nuclear Medicine, Kawasaki medical school, Okayama, Japan

    Background/Purpose: Angiotensin II (Ang II) is known to function on various organs including kidneys, adrenal glands as well as the nervous and cardiovascular systems. In…
  • Abstract Number: 1712 • 2014 ACR/ARHP Annual Meeting

    Monocytic Angiotensin and Endothelin Receptor Imbalance Determines Secretion of the Profibrotic Chemokine Ligand CCL18

    Judith Rademacher1, Jeannine Guenther2, Angela Kill3, Elise Siegert4 and Gabriela Riemekasten5, 1Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, 10117 Berlin, Germany, 2Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, 3Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, 4Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, 5Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany

    Background/Purpose Circulating monocytes are progrenitor of extra-cellular matrix producing cells involved in fibrosis and show highest expression of angiotensin II (ATR) and endothelin receptors (ETR)…
  • Abstract Number: 2230 • 2013 ACR/ARHP Annual Meeting

    Specific Angiotensin Type II Receptor Stimulation Attenuates Collagen-Induced Arthritis Via Enhancement Of FoxP3 Regulatory T Cells

    Bettina Sehnert1, Veronica Valero-Esquitino2, Georg Schett3, Ulrika Muscha Steckelings2 and Reinhard E. Voll4, 1Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency,, University Hospital Freiburg, Freiburg, Germany, 2Center for Cardiovascular Research, Medical Faculty Berlin, Berlin, Germany, 3Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany

    Background/Purpose: The renin-angiotensin system (RAS) is known to play an important role in inflammation, fibrosis, and end-organ damage. Moreover, AT2R signalling exerts anti-inflammatory and anti-apoptotic…
  • Abstract Number: 1491 • 2012 ACR/ARHP Annual Meeting

    Systemic Sclerosis – Effects of Agonistic Autoantibodies Directed Against the Angiotensin Receptor Type 1 and the Endothelin Receptor Type A On Effector Cells

    Jeannine Guenther1, Angela Kill2, Mike O. Becker3 and Gabriela Riemekasten4, 1Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, 2Rheumatology and clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, 3Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, 4Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany

    Background/Purpose: Autoimmunity, vasculopathy and fibrosis are features of systemic sclerosis (SSc). The functional link between these three pathophysiological components is still missing. Research suggests an…
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