ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 905 • 2018 ACR/ARHP Annual Meeting

    Serum Interleukin-6 Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Alvise Berti1, Roscoe Warner2, Kent Johnson3, Divi Cornec4, Darrell Schroeder5, Brian Kabat5, Carol Langford6, Gary S. Hoffman7, Cees G.M. Kallenberg8, Philip Seo9, Robert F. Spiera10, Eugene William St. Clair11, Fernando Fervenza12, John H. Stone13, Paul A. Monach14, Ulrich Specks15 and Peter A. Merkel16, 1Pulmonary and Critical Care, Mayo Clinic College of Medicine, Rochester, MN, 2University of Michigan Medical School, Ann Arbor,, MI, 3University of Michigan Medical School, Ann Arbor, MI, 4Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France, 5Mayo Clinic, Rochester, MN, 6Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 7Rheumatology, Cleveland Clinic, Cleveland, OH, 8Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 9Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 10Hospital for Special Surgery, New York, NY, 11Medicine, Duke University Medical Center, Durham, NC, 12Nephrology, Mayo Clinic, Rochester, MN, 13Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, 14Section of Rheumatology, Boston University School of Medicine, Boston, MA, 15Mayo Clinic College of Medicine, Rochester, MN, 16Division of Rheumatology and the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The deregulated overproduction of interleukin (IL)-6 has been implicated in several inflammatory and antibody-mediated autoimmune diseases. We aimed to investigate serum IL-6 levels (sIL-6)…
  • Abstract Number: 1767 • 2018 ACR/ARHP Annual Meeting

    Occurrence and Etiology of Gastrointestinal Perforation in Patients with Vasculitis

    Vanessa L. Kronzer1, Daniel Larson2, Cynthia S. Crowson3,4, Kenneth J. Warrington5, Steven R. Ytterberg5, Ashima Makol4 and Matthew J. Koster4, 1Internal Medicine, Mayo Clinic, Rochester, MN, 2Pathology, Mayo Clinic, Rochester, MN, 3Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN, 5Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN

    Background/Purpose: This study aimed to characterize the presenting features and outcomes of patients with small- or medium-vessel vasculitis and gastrointestinal perforation. Methods: Using a retrospective…
  • Abstract Number: 2733 • 2018 ACR/ARHP Annual Meeting

    From a Myth to a Menace: Increased Disease Severity and Poor Outcomes in an Urban Cohort of African-American Patients with ANCA-Associat­ed Vasculitis

    Kathleen Maksimowicz-McKinnon1, Philip McCarthy2, Sandeep Soman3 and John McKinnon3, 1Rheumatology, Henry Ford Hospital, Detroit, MI, 2Michigan State University College of Osteopathic Medicine, East Lansing, MI, 3Henry Ford Hospital, Detroit, MI

    Background/Purpose: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic inflammatory disorder frequently associated with significant disability and morbidity, which may lead to end-stage renal disease…
  • Abstract Number: 906 • 2018 ACR/ARHP Annual Meeting

    Defining the Gut Microbiome in Patients with ANCA-Associated Vasculitis

    Catherine E. Najem1, Jung-Jin Lee2, Ceylan Tanes2, Antoine G. Sreih1, Rennie L. Rhee1, Abdallah Geara3, Hongzhe Li4, Kyle Bittinger2, James D. Lewis5 and Peter A. Merkel4,6, 1Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Nephrology and Hypertension, University of Pennsylvania, Philadelphia, PA, 4Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, 5Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose:Although a link between gut microbiome and autoimmune diseases has been suggested, there is a gap in the understanding of the gut microbiome in ANCA-associated…
  • Abstract Number: 1768 • 2018 ACR/ARHP Annual Meeting

    Kidney Involvement, Poor Performance Status, and Higher Cumulative Dose of Glucocorticoid Are the Risk Factors of the Discontinuation of Immunosuppressant in Patients with Antineutrophil Cytoplasmic Antibody Associated Vasculitis

    Takamasa Murosaki, Takeo Sato, Katsuya Nagatani and Seiji Minota, Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan

    Background/Purpose: The use of immunosuppressant (IS) with glucocorticoid is recommended as remission induction treatment for severe cases with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).…
  • Abstract Number: 2734 • 2018 ACR/ARHP Annual Meeting

    The Effect of Age at Diagnosis on Mortality in ANCA-Associated Vasculitides

    Mete Kara1, Mehmet Nedim Taş1, Raika Durusoy2, Sertaç Ketenci1, Mete Pekdiker3, Hande Ece Öz4, Gülay Aşçı5, Gokhan Keser6 and Kenan Aksu4, 1Rheumatology, Ege University Medical Faculty, izmir, Turkey, 2Public Health, Ege University Medical Faculty, izmir, Turkey, 3Adult Rheumatology, Ege University Medical Faculty, izmir, Turkey, 4Rheumatology, Ege University Medical Faculty, İzmir, Turkey, 5Nephrology, Ege University Medical Faculty, İzmir, Turkey, 6Rheumatology, Ege University Medical Faculty, Izmir, Turkey

    Background/Purpose: Elderly patients with ANCA associated vasculitides (AAV) seem to have clinical differences compared to younger patients. The aim of this study is to compare…
  • Abstract Number: 907 • 2018 ACR/ARHP Annual Meeting

    Characterization of Preferential Recognition of a Chimeric Recombinant Proteinase 3 Variant By Anti-Neutrophil Cytoplasmic Antibodies

    Gwen Thompson1, Marta Casal Moura2, Darlene Nelson1, Amber Hummel1, Dieter E. Jenne3, Fernando Fervenza4, Gary S. Hoffman5, Cees G.M. Kallenberg6, Carol Langford7, Joseph W. McCune8, Peter A. Merkel9, Paul A. Monach10, Philip Seo11, Robert F. Spiera12, Eugene William St. Clair13, Steven R. Ytterberg14, John H. Stone15, William H. Robinson16, Yuan-Ping Pang1 and Ulrich Specks17, 1Mayo Clinic, Rochester, MN, 2Pulmonary and Critical Care, Thoracic Disease Research Unit, Mayo Clinic College of Medicine, Rochester, MN, 3Helmholtz Zentrum München, Munich, Germany, 4Nephrology, Mayo Clinic, Rochester, MN, 5Rheumatology, Cleveland Clinic, Cleveland, OH, 6University of Gronigen, Groningen, Netherlands, 7Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 8University of Michigan, Ann Arbor, MI, 9University of Pennsylvania, Philadelphia, PA, 10Section of Rheumatology, Boston University School of Medicine, Boston, MA, 11Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 12Hospital for Special Surgery, New York, NY, 13Medicine, Duke University Medical Center, Durham, NC, 14Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, 15Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, 16Stanford, Stanford, CA, 17Mayo Clinic College of Medicine, Rochester, MN

    Background/Purpose: Human-murine chimeric variants have been used to study specific epitope recognition by anti-neutrophil cytoplasmic antibodies (ANCAs) targeting proteinase 3 (PR3) in patients with ANCA-associated…
  • Abstract Number: 1958 • 2018 ACR/ARHP Annual Meeting

    Gene Expression Pathways across Multiple Tissues in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Reveal Core Pathways of Disease Pathology

    Marcia Friedman1, Donseok Choi1,2,3,4, Steven Planck1,4, James T. Rosenbaum5 and Cailin Sibley1, 1Oregon Health & Science University, Portland, OR, 2OHSU-PSU School of Public Health, Portland, OR, 3Graduate School of Dentistry, Kyung Hee Universtiy, Seoul, Korea, Republic of (South), 4Casey Eye Institute, Portland, OR, 5Ophthalmology, Oregon Health & Science University and Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: In recent years, several studies have characterized the gene expression signatures of different tissues affected by ANCA-associated vasculitis (AAV). The purpose of this study…
  • Abstract Number: 2735 • 2018 ACR/ARHP Annual Meeting

    Identifying ANCA-Associated Vasculitis Cases in Electronic Health Records Using Natural Language Processing

    Zachary Wallace1, John H. Stone2 and Hyon K. Choi3, 1Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA

    Background/Purpose: Epidemiologic studies of ANCA-associated vasculitis (AAV) using large data sets are often limited by the lack of validated definitions of AAV cases that can…
  • Abstract Number: 1746 • 2018 ACR/ARHP Annual Meeting

    Impact of Interstitial Lung Disease on the Long-Term Survival in 76 Japanese Patients with Microscopic Polyangiitis

    Hiromi Matsushita1, Yoshioki Yamasaki2, Yukiko Takakuwa3, Hidehiro Yamada4 and Kimito Kawahata3, 1Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 2Internal Medicie, St. Marianna University School of Medicine, Kawasaki, Japan, 3Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 4Rheumatology, Seirei Yokohama Hospital, Yokohama, Japan

    Background/Purpose: ANCA-associated vasculitis including microscopic polyangiitis (MPA) involves multiple organs including lungs. Clinical characteristics and impact on long-term survival in MPA patients with interstitial lung disease (ILD) have not…
  • Abstract Number: 1965 • 2018 ACR/ARHP Annual Meeting

    Association of HLA Class II Alleles with Relapse and Interstitial Lung Disease in Myeloperoxidsae (MPO) -ANCA Positive Vasculitis in a Japanese Population

    Aya Kawasaki1, Ken-ei Sada2, Fumio Hirano3,4, Shigeto Kobayashi5, Hidehiro Yamada6, Hiroshi Furukawa1,7, Kenji Nagasaka8, Takahiko Sugihara9, Kunihiro Yamagata10, Takayuki Sumida11, Shigeto Tohma12,13, Shoichi Ozaki6, Hiroshi Hashimoto14, Hirofumi Makino15, Yoshihiro Arimura16, Masayoshi Harigai17 and Naoyuki Tsuchiya1, 1University of Tsukuba, Faculty of Medicine, Molecular and Genetic Epidemiology Laboratory, Tsukuba, Japan, 2Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 3Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Rheumatology, Tokyo, Japan, 4Tokyo Medical and Dental UniversityGraduate School of Medical and Dental Sciences, Department of Lifetime Clinical Immunology, Tokyo, Japan, 5Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 6St. Marianna University, School of Medicine, Department of Internal Medicine, Kawasaki, Japan, 7National Hospital Organization Sagamihara l Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara, Japan, 8Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 9Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 10University of Tsukuba, Faculty of Medicine, Department of Nephrology, Tsukuba, Japan, 11Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 12National Hospital Organization Tokyo Hospital, Sagamihara, Japan, 13National Hospital Organization Tokyo National Hospital, Kiyose, Japan, 14Juntendo University School of Medicine, Tokyo, Japan, 15Okayama University Hospital, Okayama, Japan, 16Kyorin University School of Medicine, First Department of Internal Medicine, Tokyo, Japan, 17Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan

    Background/Purpose: The high prevalence of microscopic polyangiitis (MPA) and myeloperoxidase (MPO)-ANCA positive patients as well as frequent occurrence of interstitial lung disease (ILD) constitute unique…
  • Abstract Number: 2737 • 2018 ACR/ARHP Annual Meeting

    Opportunistic Infections in Medium and Small-Sized Vessel Vasculitis: Based on a Retrospectivestudy on 108 Patients

    Raphaele Mestiri1, Lafarge Antoine2, Jean-Jacques Tudesq3, Marc Pineton de Chambrun4, Melanie Roriz5, Stéphane Bally6, Laurent Alric7, Damien Sène8, Thomas Quémeneur9, Cécile-Audrey Durel10, Brigitte Gilson11, Alice Berezne12, Anne-Marie Ruppert13, Raphaele Seror14, Philippe Guilpain15, Xavier Puéchal16, Luc Mouthon17, Loïc Guillevin16 and Benjamin Terrier18, 1Internal Medicine, Cochin hospital, Paris, France, 2Medecine Interne, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 3Internal Medicine, CHU Montpellier, Montpellier, France, 4Université Pierre et Marie Curie, Paris, France, 5Université Paris-Diderot, Paris, France, 6Nephrology, CH Chambery, Chambery, France, 7Internal Medicine, CHU Toulouse, Toulouse, France, 8Lariboisière Hospital, Paris Diderot University, Paris, France, 9Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, 10Internal Medicine, Hôpital Edouard Herriot, lyon, France, 11Internal Medicine, CH Verdun, Verdun, France, 12Internal Medicine, CH Annecy, Annecy, France, 13Pulmonology, Tenon hospital, Paris, France, 14Hopitaux Universitaires Paris Sud, Kremlin Bicetre, France, Rheumatology, Université Paris Sud, Le Kremlin Bicetre, France, 15Montpellier, Montpellier, France, 16Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 17Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 18Centre de Référence des Maladies Auto-immunes et Systémiques Rares, Vascularites Nécrosantes et Sclérodermie Systémique, Service de Médecine Interne, Hôpital Cochin, APHP, INSERM U1016, Université Paris Descartes, Paris, France

    Background/Purpose: Overall survival has been markedly improved during the last decades in systemic vasculitis. In contrast, the use of immunosuppressive agents led to an increased…
  • Abstract Number: 1747 • 2018 ACR/ARHP Annual Meeting

    Long-Term Outcomes of Patients with Nonsevere Eosinophilic Granulomatosis with Polyangiitis Given Azathioprine and Glucocorticoids for Remission Induction

    Xavier Puéchal1, Christian Pagnoux2, Gabriel Baron3, François Lifermann4, Loïk Geffray5, Thomas Quémeneur6, Jean-Luc Saraux7, Marie Wislez8, Vincent Cottin9, Marc Ruivard10, Nicolas Limal11, Achille Aouba12, Bernard Bonnotte13, Antoine Neel14, Christian Agard15, Pascal Cohen16, Benjamin Terrier17, Claire Le Jeunne17, Luc Mouthon1, Philippe Ravaud3 and Loïc Guillevin for the French Vasculitis Study Group17, 1Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 2Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 3Paris Hôtel Dieu, Paris, France, 4Dax, Dax, France, 5Lisieux, Lisieux, France, 6Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, 7Eaubonne, Eaubonne, France, 8Paris Tenon, Paris, Gambia, 9Lyon Louis Pradel, Lyon, France, 10Clermont-Ferrand, Clermont Ferrand, France, 11Créteil Henri Mondor, Créteil, France, 12Caen, Caen, France, 13Dijon, Dijon, France, 14Medecine Interne, Nantes Hôtel Dieu, Nantes, France, 15Nantes Hôtel Dieu, Nantes, France, 16Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 17National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France

    Background/Purpose: At month 24 (M24), CHUSPAN2-trial patients with nonsevere eosinophilic granulomatosis with polyangiitis (EGPA), who received 1 yr of azathioprine (AZA) and glucocorticoids (GC) as…
  • Abstract Number: 1967 • 2018 ACR/ARHP Annual Meeting

    Detection of Association of Long Noncoding RNA ATP6V0E2-AS1 Single Nucleotide Polymorphism with Susceptibility to Myeloperoxidase-ANCA Associated Vasculitis Based on Transcriptome Analysis

    Yuka Iwahashi1,2, Aya Kawasaki1,2, Takayo Tsuchiura3, Ken-ei Sada4, Fumio Hirano5,6, Daisuke Tsukui7, Shigeto Kobayashi8, Hidehiro Yamada9, Hiroshi Furukawa1,2,10, Kenji Nagasaka11, Takahiko Sugihara12, Nao Nishida3, Kunihiro Yamagata13, Takayuki Sumida14, Shigeto Tohma10,15, Shoichi Ozaki9, Hiroshi Hashimoto16, Hirofumi Makino17, Yoshihiro Arimura18, Hajime Kono19, Masayoshi Harigai20 and Naoyuki Tsuchiya1,2, 1University of Tsukuba, Graduate School of Comprehensive Human Sciences, Masters' Program in Medical Sciences, Tsukuba, Japan, 2University of Tsukuba, Faculty of Medicine, Molecular and Genetic Epidemiology Laboratory, Tsukuba, Japan, 3Genome Medical Science Project, National Center for Global Health and Medicine, Research Center for Hepatitis and Immunology, Ichikawa, Japan, 4Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 5Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Rheumatology, Tokyo, Japan, 6Tokyo Medical and Dental UniversityGraduate School of Medical and Dental Sciences, Department of Lifetime Clinical Immunology, Tokyo, Japan, 7Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 8Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 9St. Marianna University, School of Medicine, Department of Internal Medicine, Kawasaki, Japan, 10National Hospital Organization Sagamihara l Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara, Japan, 11Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 12Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 13University of Tsukuba, Faculty of Medicine, Department of Nephrology, Tsukuba, Japan, 14Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 15National Hospital Organization Tokyo National Hospital, Kiyose, Japan, 16Juntendo University School of Medicine, Tokyo, Japan, 17Okayama University Hospital, Okayama, Japan, 18Kyorin University School of Medicine, First Department of Internal Medicine, Tokyo, Japan, 19Teikyo University School of Medicine, Department of Internal Medicine, Tokyo, Japan, 20Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan

    Background/Purpose: Because of the low prevalence, only three genome-wide association studies, all from the Caucasian populations, have been reported on ANCA-associated vasculitis (AAV) thus far;…
  • Abstract Number: 2738 • 2018 ACR/ARHP Annual Meeting

    A Randomized Phase 3 Trial Evaluating the Safety and Efficacy of Avacopan in Patients with New or Relapsing Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

    Peter A. Merkel1, David Jayne2, Thomas J. Schall3, Pirow Bekker3 and Jan Hillson3, 1Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3ChemoCentryx, Mountain View, CA

    A Randomized Phase 3 Trial Evaluating the Safety and Efficacy of Avacopan in Patients with New or Relapsing Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisPeter A. Merkel1, David…
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